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Browsing by Author Elliot, David John

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PreviewIssue DateTitleAuthor(s)
2008The "Albumin Effect" and in Vitro-in Vivo Extrapolation: Sequestration of Long-Chain Unsaturated Fatty Acids Enhances Phenytoin Hydroxylation by Human Liver Microsomal and Recombinant Cytochrome P450 2C9Mackenzie, Peter Ian; Miners, John Oliver; Rowland, Andrew; Elliot, David John; Knights, Kathleen Mary
2009Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: Inhibition by NSAIDsKnights, Kathleen Mary; Winner, Leanne; Elliot, David John; Bowalgaha, Kushari; Miners, John Oliver
2007Amino terminal domains of human UDP-glucuronosyltransferases (UGT) 2B7 and 2B15 associated with substrate selectivity and autoactivationLewis, Benjamin Cavell; Mackenzie, Peter Ian; Elliot, David John; Burchell, Brian; Bhasker, Ramana; Miners, John Oliver
2007Binding of inhibitory fatty acids is responsible for the enhancement of UDP-Glucuronosyltransferase 2B7 activity by albumin: implications for in vitro-in vivo extrapolationRowland, Andrew; Miners, John Oliver; Gaganis, Paraskevi; Elliot, David John; Mackenzie, Peter Ian; Knights, Kathleen Mary
2007Critical roles of residues 36 and 40 in the phenol and tertiary amine aglycone substrate selectivities of UDP-glucuronosyltransferases 1A3 and 1A4Kubota, Takahiro; Mackenzie, Peter Ian; Miners, John Oliver; Lewis, Benjamin Cavell; Elliot, David John
2004Differential contribution of active site residues in substrate recognition sites 1 and 5 to cytochrome P450 2C8 substrate selectivity and regioselectivityYoovathaworn, Krontong; Kerdpin, Oranun; Miners, John Oliver; Boye, S; Birkett, Donald John; Elliot, David John
2005Electrochemical characterisation of the human cytochrome P450 CYP2C9Lewis, Benjamin Cavell; Johnson, D L; Miners, John Oliver; Martin, L L; Elliot, David John
2006An evaluation of potential mechanism-based inactivation of human drug metabolizing cytochromes P450 by monoamine oxidase inhibitors, including isoniazidPolasek, Thomas Metodey; Elliot, David John; Somogyi, Andrew A; Gillam, Elizabeth M J; Lewis, Benjamin Cavell; Miners, John Oliver
2007The glucuronidation of delta4-3-keto C19- and C21-hydroxysteroids by human liver microsomal and recombinant UDP-glucuronosyltransferases (UGTs): 6alpha- and 21-hydroxyprogesterone are selective substrates for UGT2B7Bowalgaha Ralalage, Kushari Wathsala; Elliot, David John; Mackenzie, Peter Ian; Knights, Kathleen Mary; Miners, John Oliver
2007Identification of the human cytochromes P450 catalysing the rate-limiting pathways of gliclazide eliminationMiners, John Oliver; Suharjono, M S; Lewis, Benjamin Cavell; Gillam, Elizabeth M J; Birkett, Donald John; Gross, A; Elliot, David John
2007Influence of mutations associated with Gilbert and Crigler-Najjar type II syndromes on the glucuronidation kinetics of bilirubin and other UDP-glucuronosyltransferase 1A substratesElliot, David John; Miners, John Oliver; Udomuksorn, Wandee; Lewis, Benjamin Cavell; Mackenzie, Peter Ian; Yoovathaworn, Krontong
2008In vitro characterisation of human renal and hepatic frusemide glucuronidation and identification of the UDP-glucuronosyltransferase enzymes involved in this pathwayKerdpin, Oranun; Knights, Kathleen Mary; Elliot, David John; Miners, John Oliver
2006In vitro characterization of lamotrigine N2-glucuronidation and the lamotrigine-valproic acid interactionRowland, Andrew; Elliot, David John; Williams, Andrew; Mackenzie, Peter Ian; Dickinson, Ronald G; Miners, John Oliver
2007In vitro-in vivo extrapolation of drug glucuronidation kinetic parameters: Pitfalls and PromisesMiners, John Oliver; Rowland, Andrew; Uchaipichat, Verawan Nu; Elliot, David John; Knights, Kathleen Mary; Galetin, A; Houston, J Brian; Mackenzie, Peter Ian
2010In vitro-in vivo extrapolation of zolpidem as a perpetrator of metabolic interactions involving CYP3APolasek, Thomas Metodey; Sadagopal, Janani Soundarya; Elliot, David John; Miners, John Oliver
2010In Vitro-In Vivo Extrapolation Predicts Drug-Drug Interactions Arising from Inhibition of Codeine Glucuronidation by Dextropropoxyphene, Fluconazole, Ketoconazole, and Methadone in HumansJanchawee, Benjamas; Raungrut, Pritsana; Uchaipichat, Verawan Nu; Elliot, David John; Somogyi, Andrew A; Miners, John Oliver
2006Measurement of Human Cytochrome P4501A2 (CYP1A2) Activity in VitroPolasek, Thomas Metodey; Elliot, David John; Miners, John Oliver
2004Mechanism-based inactivation of human cytochrome PO4502C8 by drugs in vitroPolasek, Thomas Metodey; Lewis, Benjamin Cavell; Miners, John Oliver; Elliot, David John
2004Optimizing bacterial expression of catalytically active human cytochromes P450: comparison of CYP2C8 and CYP2C9Yoovathaworn, Krontong; Kerdpin, Oranun; Miners, John Oliver; Boye, S; Bhasker, Ramana; Birkett, Donald John; Elliot, David John; Kelly, L; McKinnon, Ross A
2006Quantitative prediction of in vivo inhibitory interactions involving glucuronidated drugs from in vitro data: the effect of fluconazole on zidovudine glucuronidationWinner, Leanne; Mackenzie, Peter Ian; Elliot, David John; Williams, Andrew; Miners, John Oliver; Uchaipichat, Verawan Nu
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