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Browsing by Author Mackenzie, Peter Ian

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PreviewIssue DateTitleAuthor(s)
2005Human UDP-glucuronosyltransferase 1A5: indentification, expression and activityFinel, Moshe; Li, X; Gardner-Stephen, Dione Anne; Bratton, S; Mackenzie, Peter Ian; Radominska-Pandya, A
10-Jul-2012Human UDP-Glucuronosyltransferase expression in insect cells: ratio of active to inactive recombinant proteins and the effects of a C-terminal His-tag on glucuronidation kineticsZhang, Hongbo; Patana, Anne-Sisko; Mackenzie, Peter Ian; Ikushiro, Shin-ichi; Goldman, Adrian; Finel, Moshe
2004Human UDP-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumberlliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecidGuo, X H; Uchaipichat, Verawan Nu; Miners, John Oliver; Mackenzie, Peter Ian; Gardner-Stephen, Dione Anne; Galetin, A; Houston, J Brian
2005Identification and characterization of functional hepatocyte nuclear factor 1-binding sites in UDP-glucuronosyltransferase genesGregory, Philip A; Gardner-Stephen, Dione Anne; Mackenzie, Peter Ian
Jul-2012Identification of Residues That Confer Sugar Selectivity to UDP-Glycosyltransferase 3A (UGT3A) EnzymesMeech, Robyn; Rogers, Anne; Zhuang, Lizhe; Lewis, Benjamin Cavell; Miners, John Oliver; Mackenzie, Peter Ian
2008Identification of UDP Glycosyltransferase 3A1 as a UDP N-AcetylglucosaminyltransferaseMackenzie, Peter Ian; Rogers, Anne; Jorgensen, B R; Miners, John Oliver; Meech, Robyn; Gillis, Joanna Lee
2007Influence of mutations associated with Gilbert and Crigler-Najjar type II syndromes on the glucuronidation kinetics of bilirubin and other UDP-glucuronosyltransferase 1A substratesElliot, David John; Miners, John Oliver; Udomuksorn, Wandee; Lewis, Benjamin Cavell; Mackenzie, Peter Ian; Yoovathaworn, Krontong
2009Influence of N-Terminal Domain Histidine and Proline Residues on the Substrate Selectivities of Human UDP-Glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10Kerdpin, Oranun; Mackenzie, Peter Ian; Bowalgaha Ralalage, Kushari Wathsala; Finel, Moshe; Miners, John Oliver
8-Aug-2012Inhibition of morphine glucuronidation in the liver microsomes of rats and humans by monoterpenoid alcoholsIshii, Yuji; Iida, Naoko; Miyauchi, Yuu; Mackenzie, Peter Ian; Yamada, Hideyuki
2006Inhibition of UDP-glucuronosyltransferase 2B7-catalyzed morphine glucuronidation by Ketoconazole: Dual mechanisms involving a novel non-competitive modeTakeda, Shuso; Kitajima, Yurie; Ishii, Yuji; Nishimura, Yoshio; Mackenzie, Peter Ian; Oguri, Kazuta; Yamada, Hideyuki
2007Inhibitory effects of adenine nucleotides and related substances on UDP-glucuronosyltransferase: structure-effect relationships and evidence for an allosteric mechanismYamada, Hideyuki; Maeda, Shingo; Ikushiro, Shin-ichi; Mackenzie, Peter Ian; Ishii, Yuji; Nishimura, Yoshio
2009Interaction of Cytochrome P450 3A4 and UDP-Glucuronosyltransferase 2B7: Evidence for Protein-Protein Association and Possible Involvement of CYP3A4 J-Helix in the InteractionTakeda, Shuso; Ishii, Yuji; Iwanaga, Megumi; Nurrochmad, Arief; Ito, Yuji; Mackenzie, Peter Ian; Nagata, Kiyoshi; Yamazoe, Yasushi; Oguri, Kazuta; Yamada, Hideyuki
2007Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6Court, M H; Tate, Christopher G; Hirvonen, Jouni; Kurkela, Mika; Patana, Anne-Sisko; Mackenzie, Peter Ian; Goldman, Adrian; Finel, Moshe
2010The In Vitro Characterization of Inhibitory Drug-Drug Interactions Involving UDP-GlucuronosyltransferaseMiners, John Oliver; Polasek, Thomas Metodey; Mackenzie, Peter Ian; Knights, Kathleen Mary
2006In vitro characterization of lamotrigine N2-glucuronidation and the lamotrigine-valproic acid interactionRowland, Andrew; Elliot, David John; Williams, Andrew; Mackenzie, Peter Ian; Dickinson, Ronald G; Miners, John Oliver
2006In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: Pitfalls and promisesMiners, John Oliver; Knights, Kathleen Mary; Houston, J Brian; Mackenzie, Peter Ian
2007In vitro-in vivo extrapolation of drug glucuronidation kinetic parameters: Pitfalls and PromisesMiners, John Oliver; Rowland, Andrew; Uchaipichat, Verawan Nu; Elliot, David John; Knights, Kathleen Mary; Galetin, A; Houston, J Brian; Mackenzie, Peter Ian
2003Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human UDP-glucuronosyltranferases: evidence for atypical glucuronidation kinetics by UGT2B7.Stone, A N; Miners, John Oliver; Mackenzie, Peter Ian; Galetin, A; Houston, J Brian
2007Isolation of the UDP-glucuronosyltransferase 1A3 and 1A4 proximal promoters and characterization of their dependence on the transcription factor hepatocyte nuclear factor 1 alphaGardner-Stephen, Dione Anne; Mackenzie, Peter Ian
2008Kinetic modeling of the interactions between 4-Methylumbelliferone, 1-Naphthol, and zidovudine glucuronidation by UDP-glucuronosyltransferase 2B7 (UGT2B7) provides evidence for multiple substrate binding and effector sitesGaletin, A; Mackenzie, Peter Ian; Williams, Andrew; Miners, John Oliver; Uchaipichat, Verawan Nu; Houston, J Brian
Showing results 26 to 45 of 69
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