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Browsing by Author Mackenzie, Peter Ian

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PreviewIssue DateTitleAuthor(s)
2006In vitro characterization of lamotrigine N2-glucuronidation and the lamotrigine-valproic acid interactionRowland, Andrew; Elliot, David John; Williams, Andrew; Mackenzie, Peter Ian; Dickinson, Ronald G; Miners, John Oliver
2006In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: Pitfalls and promisesMiners, John Oliver; Knights, Kathleen Mary; Houston, J Brian; Mackenzie, Peter Ian
2007In vitro-in vivo extrapolation of drug glucuronidation kinetic parameters: Pitfalls and PromisesMiners, John Oliver; Rowland, Andrew; Uchaipichat, Verawan Nu; Elliot, David John; Knights, Kathleen Mary; Galetin, A; Houston, J Brian; Mackenzie, Peter Ian
2003Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human UDP-glucuronosyltranferases: evidence for atypical glucuronidation kinetics by UGT2B7.Stone, A N; Miners, John Oliver; Mackenzie, Peter Ian; Galetin, A; Houston, J Brian
2007Isolation of the UDP-glucuronosyltransferase 1A3 and 1A4 proximal promoters and characterization of their dependence on the transcription factor hepatocyte nuclear factor 1 alphaGardner-Stephen, Dione Anne; Mackenzie, Peter Ian
2008Kinetic modeling of the interactions between 4-Methylumbelliferone, 1-Naphthol, and zidovudine glucuronidation by UDP-glucuronosyltransferase 2B7 (UGT2B7) provides evidence for multiple substrate binding and effector sitesGaletin, A; Mackenzie, Peter Ian; Williams, Andrew; Miners, John Oliver; Uchaipichat, Verawan Nu; Houston, J Brian
2008Liver-enriched transcription factors and their role in regulating UDP glucuronosyltransferase gene expressionGardner-Stephen, Dione Anne; Mackenzie, Peter Ian
2005Modulation of UDP-glucuronosyltransferase 2B7 function by cytochrome P450s in vitro: Differential effects of CYP1A2, CYP2C9 and CYP3A4Takeda, Shuso; Ishii, Yuji; Mackenzie, Peter Ian; Nagata, Kiyoshi; Yamazoe, Yasushi; Oguri, Kazuta; Yamada, Hideyuki
2005Modulation of UDP-glucuronosyltransferase function by cytochrome P450: Evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4Takeda, Shuso; Ishii, Yuji; Iwanaga, Megumi; Mackenzie, Peter Ian; Nagata, Kiyoshi; Yamazoe, Yasushi; Oguri, Kazuta; Yamada, Hideyuki
2005Polymorphic variations in the expression of the chemical detoxifying UDP glucuronosytransferasesMackenzie, Peter Ian; Gregory, Philip A; Lewinsky, Rikke Holm; Yasmin, S N; Height, T; MacKinnon, R A; Gardner-Stephen, Dione Anne
2004Predicating Human Drug Glucuronidation Parameters: Application of In Vitro and InSilico Modeling ApproachesSmith, Paul Alexander; Miners, John Oliver; Mackenzie, Peter Ian; McKinnon, Ross A; Sorich, Michael J
2006Quantitative prediction of in vivo inhibitory interactions involving glucuronidated drugs from in vitro data: the effect of fluconazole on zidovudine glucuronidationWinner, Leanne; Mackenzie, Peter Ian; Elliot, David John; Williams, Andrew; Miners, John Oliver; Uchaipichat, Verawan Nu
2008Recent advances in the in silico modelling of UDP Glucuronosyltransferase SubstratesMiners, John Oliver; Mackenzie, Peter Ian; McKinnon, Ross A; Sorich, Michael J; Smith, Paul Alexander
2003Regulation of UDP glucuronosyltransferase genes.Nishiyama, T; Xie, W; Gregory, Philip A; Lewinsky, Rikke Holm; Jorgensen, B R; Mackenzie, Peter Ian; Gardner-Stephen, Dione Anne; Radominska-Pandya, A
2004Regulation of UDP-glucuronosyltransferases in the gastrointestinal tractGregory, Philip A; Lewinsky, Rikke Holm; Mackenzie, Peter Ian; Gardner-Stephen, Dione Anne
2006Relationship between hyperbilirubinaemia and UDP-glucoronosyltransferase 1A1 (UGT1A1) polymorphism in adult HIV-infected Thai patients treated with indinavirBoyd, Mark Alastair; Srasuebkul, Preeyaporn; Ruxrungtham, Kiat; Uchaipichat, Verawan Nu; Mackenzie, Peter Ian; Stek, Michael; Lange, Joep M A; Phanuphak, Praphan; Cooper, David A; Udomuksorn, Wandee; Miners, John Oliver
2006Selectivity of substrate (trifluoperazine) and inhibitor (amitriptyline, androsterone, canrenoic acid, hecogenin, phenylbutazone, quinidine, quinine, and sulfinpyrazone) 'probes' for human UDP-glucuronosyltransferasesUchaipichat, Verawan Nu; Mackenzie, Peter Ian; Elliot, David John; Miners, John Oliver
2005S-Naproxen and desmethylnaproxen glucuronidation by human liver miscrosomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxenBowalgaha Ralalage, Kushari Wathsala; Mackenzie, Peter Ian; Knights, Kathleen Mary; Swedmark, S; Miners, John Oliver; Elliot, David John
2006Sulfinpyrazone C-Glucuronidation Is Catalyzed Selectively by Human UDP-Glucuronosyltransferase 1A9Kerdpin, Oranun; Elliot, David John; Mackenzie, Peter Ian; Miners, John Oliver
2004Transciptional Regulation of UDP-GlucuronosyltransferasesXie, W; Mackenzie, Peter Ian; Radominska-Pandya, A
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