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Flinders Academic Commons >
Browsing by Author Mackenzie, Peter Ian
Showing results 1 to 20 of 47
| Issue Date | Title | Author(s) | | 2008 | The "albumin effect" and drug
glucuronidation: bovine serum albumin and fatty acid-free human serum albumin enhance
the glucuronidation of UDP-glucuronosyltransferase (UGT) 1A9 substrates but not UGT1A1
and UGT1A6 activities | Mackenzie, Peter Ian; Miners, John Oliver; Knights, Kathleen Mary; Rowland, Andrew |
| 2008 | The "Albumin Effect" and in Vitro-in
Vivo Extrapolation: Sequestration of Long-Chain Unsaturated Fatty Acids Enhances
Phenytoin Hydroxylation by Human Liver Microsomal and Recombinant Cytochrome P450
2C9 | Mackenzie, Peter Ian; Miners, John Oliver; Rowland, Andrew; Elliot, David John; Knights, Kathleen Mary |
| 2007 | Amino terminal domains of human
UDP-glucuronosyltransferases (UGT) 2B7 and 2B15 associated with substrate selectivity
and autoactivation | Lewis, Benjamin Cavell; Mackenzie, Peter Ian; Elliot, David John; Burchell, Brian; Bhasker, Ramana; Miners, John Oliver |
| 2007 | Binding of inhibitory fatty acids is responsible
for the enhancement of UDP-Glucuronosyltransferase 2B7 activity by albumin: implications
for in vitro-in vivo extrapolation | Rowland, Andrew; Miners, John Oliver; Gaganis, Paraskevi; Elliot, David John; Mackenzie, Peter Ian; Knights, Kathleen Mary |
| 2007 | Carboxylic Acid Drug-Induced DNA Nicking in HEK293
Cells Expressing Human UDP-Glucuronosyltransferases: Role of Acyl Glucuronide
Metabolites and Glycation Pathways | Mackenzie, Peter Ian; DeGraaf, Yvette; Southwood, H; Burcham, P; Miners, John Oliver; Sallustio, B |
| 2006 | The caudal-related homeodomain protein Cdx2 and
hepatocyte nuclear factor 1-alpha cooperatively regulate the UDP-glucuronosyltransferase
2B7 gene promotor | Gregory, Philip A; Gardner-Stephen, Dione Anne; Rogers, Anne; Michael, Michael Zenon; Mackenzie, Peter Ian |
| 2003 | Cloning and characterization of the human
UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 gene promoters: differential regulation
through an intitiator-like region. | Gregory, Philip A; Lewinsky, Rikke Holm; Mackenzie, Peter Ian; Gardner-Stephen, Dione Anne; Duncliffe, K N |
| 2007 | Comparative homology modeling of human cytochrome
P4501A1 (CYP1A1) and confirmation of residues involved in 7-ethoxyresorufin
O-deethylation by site-directed mutagenesis and enzyme kinetic analysis | Miners, John Oliver; Lewis, Benjamin Cavell; Mackenzie, Peter Ian |
| 2008 | The configuration of the 17-hydroxy group variably
influences the glucuronidation of B-estradiol and epiestradiol by human
UDP-Glucuronosyltransferases | Itaaho, Katrina; Mackenzie, Peter Ian; Ikushiro, Shin-ichi; Miners, John Oliver; Finel, Moshe |
| 2004 | Coordinate regulation of the human
UDP-glucuronosyltransferase 1A8, 1A9 and 1A10 genes by hepatocyte nuclear factor 1-alpha
and the caudal-related homeodomain protein 2 | Gregory, Philip A; Lewinsky, Rikke Holm; Mackenzie, Peter Ian; Gardner-Stephen, Dione Anne |
| 2007 | Critical roles of residues 36 and 40 in the phenol
and tertiary amine aglycone substrate selectivities of UDP-glucuronosyltransferases 1A3
and 1A4 | Kubota, Takahiro; Mackenzie, Peter Ian; Miners, John Oliver; Lewis, Benjamin Cavell; Elliot, David John |
| 2006 | Fatty acyl-CoA as an endogenous activator of
UDP-glucuronosyltransferases | Okamura, Kazuharu; Ishii, Yuji; Ikushiro, Shin-ichi; Mackenzie, Peter Ian; Yamada, Hideyuki |
| 2003 | Glucosidation of hyodeoxycholic acid by
UDP-glucuronosyltransferase 2B7. | Mackenzie, Peter Ian; Radominska-Pandya, A; Little, J M |
| 2004 | Glucuronidation and the
UDP-glucuronosyltransferases in health and disease | Wells, P G; Hansen, A J; Gregory, Philip A; Ishii, Yuji; Mackenzie, Peter Ian; Guillemette, Chantal; Chowdhury, J R; Choudhury, Namita R; Kessler, F K; Kim, P M; Ritter, J K |
| 2005 | Glucuronidation of bioflavonoids by human UGT1A10:
structure-function relationships | Lewinsky, Rikke Holm; Smith, Paul Alexander; Mackenzie, Peter Ian |
| 2007 | The glucuronidation of delta4-3-keto C19- and
C21-hydroxysteroids by human liver microsomal and recombinant
UDP-glucuronosyltransferases (UGTs): 6alpha- and 21-hydroxyprogesterone are selective
substrates for UGT2B7 | Bowalgaha Ralalage, Kushari Wathsala; Elliot, David John; Mackenzie, Peter Ian; Knights, Kathleen Mary; Miners, John Oliver |
| 2007 | Hepatocyte nuclear factor1 transcription factors
are essential for the UDP-glucuronosyltransferase 1A9 promoter response to hepatocyte
nuclear factor 4alpha | Gardner-Stephen, Dione Anne; Mackenzie, Peter Ian |
| 2004 | Human PXR variants and their differential effects
on the regulation of human UDP-glucuronosyltransferase gene expression | Xie, W; Mackenzie, Peter Ian; Gardner-Stephen, Dione Anne; Radominska-Pandya, A; Goyal, A; Heydel, J M; Lindblom, T; Lu, Y |
| 2005 | Human UDP-glucuronosyltransferase 1A5:
indentification, expression and activity | Finel, Moshe; Li, X; Gardner-Stephen, Dione Anne; Bratton, S; Mackenzie, Peter Ian; Radominska-Pandya, A |
| 2004 | Human UDP-glucuronosyltransferases: isoform
selectivity and kinetics of 4-methylumberlliferone and 1-naphthol glucuronidation,
effects of organic solvents, and inhibition by diclofenac and probenecid | Guo, X H; Uchaipichat, Verawan Nu; Miners, John Oliver; Mackenzie, Peter Ian; Gardner-Stephen, Dione Anne; Galetin, A; Houston, J Brian |
Showing results 1 to 20 of 47
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