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Browsing by Author Mackenzie, Peter Ian

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PreviewIssue DateTitleAuthor(s)
2005Identification and characterization of functional hepatocyte nuclear factor 1-binding sites in UDP-glucuronosyltransferase genesGregory, Philip A; Gardner-Stephen, Dione Anne; Mackenzie, Peter Ian
2008Identification of UDP Glycosyltransferase 3A1 as a UDP N-AcetylglucosaminyltransferaseMackenzie, Peter Ian; Rogers, Anne; Jorgensen, B R; Miners, John Oliver; Meech, Robyn; Gillis, Joanna Lee
2007Influence of mutations associated with Gilbert and Crigler-Najjar type II syndromes on the glucuronidation kinetics of bilirubin and other UDP-glucuronosyltransferase 1A substratesElliot, David John; Miners, John Oliver; Udomuksorn, Wandee; Lewis, Benjamin Cavell; Mackenzie, Peter Ian; Yoovathaworn, Krontong
8-Aug-2012Inhibition of morphine glucuronidation in the liver microsomes of rats and humans by monoterpenoid alcoholsIshii, Yuji; Iida, Naoko; Miyauchi, Yuu; Mackenzie, Peter Ian; Yamada, Hideyuki
2006Inhibition of UDP-glucuronosyltransferase 2B7-catalyzed morphine glucuronidation by Ketoconazole: Dual mechanisms involving a novel non-competitive modeTakeda, Shuso; Kitajima, Yurie; Ishii, Yuji; Nishimura, Yoshio; Mackenzie, Peter Ian; Oguri, Kazuta; Yamada, Hideyuki
2007Inhibitory effects of adenine nucleotides and related substances on UDP-glucuronosyltransferase: structure-effect relationships and evidence for an allosteric mechanismYamada, Hideyuki; Maeda, Shingo; Ikushiro, Shin-ichi; Mackenzie, Peter Ian; Ishii, Yuji; Nishimura, Yoshio
2007Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6Court, M H; Tate, Christopher G; Hirvonen, Jouni; Kurkela, Mika; Patana, Anne-Sisko; Mackenzie, Peter Ian; Goldman, Adrian; Finel, Moshe
2006In vitro characterization of lamotrigine N2-glucuronidation and the lamotrigine-valproic acid interactionRowland, Andrew; Elliot, David John; Williams, Andrew; Mackenzie, Peter Ian; Dickinson, Ronald G; Miners, John Oliver
2006In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: Pitfalls and promisesMiners, John Oliver; Knights, Kathleen Mary; Houston, J Brian; Mackenzie, Peter Ian
2007In vitro-in vivo extrapolation of drug glucuronidation kinetic parameters: Pitfalls and PromisesMiners, John Oliver; Rowland, Andrew; Uchaipichat, Verawan Nu; Elliot, David John; Knights, Kathleen Mary; Galetin, A; Houston, J Brian; Mackenzie, Peter Ian
2003Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human UDP-glucuronosyltranferases: evidence for atypical glucuronidation kinetics by UGT2B7.Stone, A N; Miners, John Oliver; Mackenzie, Peter Ian; Galetin, A; Houston, J Brian
2007Isolation of the UDP-glucuronosyltransferase 1A3 and 1A4 proximal promoters and characterization of their dependence on the transcription factor hepatocyte nuclear factor 1 alphaGardner-Stephen, Dione Anne; Mackenzie, Peter Ian
2008Kinetic modeling of the interactions between 4-Methylumbelliferone, 1-Naphthol, and zidovudine glucuronidation by UDP-glucuronosyltransferase 2B7 (UGT2B7) provides evidence for multiple substrate binding and effector sitesGaletin, A; Mackenzie, Peter Ian; Williams, Andrew; Miners, John Oliver; Uchaipichat, Verawan Nu; Houston, J Brian
2008Liver-enriched transcription factors and their role in regulating UDP glucuronosyltransferase gene expressionGardner-Stephen, Dione Anne; Mackenzie, Peter Ian
2005Modulation of UDP-glucuronosyltransferase 2B7 function by cytochrome P450s in vitro: Differential effects of CYP1A2, CYP2C9 and CYP3A4Takeda, Shuso; Ishii, Yuji; Mackenzie, Peter Ian; Nagata, Kiyoshi; Yamazoe, Yasushi; Oguri, Kazuta; Yamada, Hideyuki
2005Modulation of UDP-glucuronosyltransferase function by cytochrome P450: Evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4Takeda, Shuso; Ishii, Yuji; Iwanaga, Megumi; Mackenzie, Peter Ian; Nagata, Kiyoshi; Yamazoe, Yasushi; Oguri, Kazuta; Yamada, Hideyuki
2005Polymorphic variations in the expression of the chemical detoxifying UDP glucuronosytransferasesMackenzie, Peter Ian; Gregory, Philip A; Lewinsky, Rikke Holm; Yasmin, S N; Height, T; MacKinnon, R A; Gardner-Stephen, Dione Anne
May-2014Polymorphisms and Haplotypes of the UDP-Glucuronosyltransferase 2B7 Gene PromoterHu, Dong; Meech, Robyn; Lu, Lu; McKinnon, Ross A; Mackenzie, Peter Ian
2004Predicating Human Drug Glucuronidation Parameters: Application of In Vitro and InSilico Modeling ApproachesSmith, Paul Alexander; Miners, John Oliver; Mackenzie, Peter Ian; McKinnon, Ross A; Sorich, Michael J
2006Quantitative prediction of in vivo inhibitory interactions involving glucuronidated drugs from in vitro data: the effect of fluconazole on zidovudine glucuronidationWinner, Leanne; Mackenzie, Peter Ian; Elliot, David John; Williams, Andrew; Miners, John Oliver; Uchaipichat, Verawan Nu
Showing results 25 to 44 of 55
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