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Browsing by Author Knights, Kathleen Mary

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PreviewIssue DateTitleAuthor(s)
2008The "albumin effect" and drug glucuronidation: bovine serum albumin and fatty acid-free human serum albumin enhance the glucuronidation of UDP-glucuronosyltransferase (UGT) 1A9 substrates but not UGT1A1 and UGT1A6 activitiesMackenzie, Peter Ian; Miners, John Oliver; Knights, Kathleen Mary; Rowland, Andrew
2008The "Albumin Effect" and in Vitro-in Vivo Extrapolation: Sequestration of Long-Chain Unsaturated Fatty Acids Enhances Phenytoin Hydroxylation by Human Liver Microsomal and Recombinant Cytochrome P450 2C9Mackenzie, Peter Ian; Miners, John Oliver; Rowland, Andrew; Elliot, David John; Knights, Kathleen Mary
2009Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: Inhibition by NSAIDsKnights, Kathleen Mary; Winner, Leanne; Elliot, David John; Bowalgaha, Kushari; Miners, John Oliver
2007Amino acid conjugation: contribution to the metabolism and toxicity of xenobiotic carboxylic acidsKnights, Kathleen Mary; Sykes, Matthew James; Miners, John Oliver
2007Binding of inhibitory fatty acids is responsible for the enhancement of UDP-Glucuronosyltransferase 2B7 activity by albumin: implications for in vitro-in vivo extrapolationRowland, Andrew; Miners, John Oliver; Gaganis, Paraskevi; Elliot, David John; Mackenzie, Peter Ian; Knights, Kathleen Mary
2009Characterization of the Binding of Drugs to Human Intestinal Fatty Acid Binding Protein (IFABP): Potential Role of IFABP as an Altenative to Albumin for in Vitro-in Vivo Extrapolation of Drug Kinetic ParametersRowland, Andrew; Knights, Kathleen Mary; Mackenzie, Peter Ian; Miners, John Oliver
2010Defining the COX inhibitor selectivity of NSAIDS: implications for understanding toxicityKnights, Kathleen Mary; Mangoni, Arduino Aleksander; Miners, John Oliver
2007Envenomation and AntivenomBryant, Bronwen Jean; Knights, Kathleen Mary
2010Enzymology of Amino Acid Conjugation ReactionsKnights, Kathleen Mary; Vessey, D A
2004Evidence that unsaturated fatty acids are potent inhibitors of renal UDP-glucuronosyltransferases (UGT): kinetic studies using human kidney cortical microsomes and recombinant UGT1A9 and UGT2B7Tsoutsikos, Paraskevi; Stapleton, Alan Murray; Thomas, Anthony Charles; Knights, Kathleen Mary; Miners, John Oliver; Sallustio, B
2007The glucuronidation of delta4-3-keto C19- and C21-hydroxysteroids by human liver microsomal and recombinant UDP-glucuronosyltransferases (UGTs): 6alpha- and 21-hydroxyprogesterone are selective substrates for UGT2B7Bowalgaha Ralalage, Kushari Wathsala; Elliot, David John; Mackenzie, Peter Ian; Knights, Kathleen Mary; Miners, John Oliver
2007Glucuronidation of fenamates: kinetic studies using human kidney corticol microsomes and recombinant UDP-glucuronosyltransferase (UGT) 1A9 and 2B7Gaganis, Paraskevi; Miners, John Oliver; Knights, Kathleen Mary
2007Human renal cortical and medullary UDP-glucuronosyltransferases (UGTs): immunohistochemical localization of UGT2B7 and UGT1A enzymes and kinetic characterization of s-naproxen glucuronidationThomas, Anthony Charles; Gaganis, Paraskevi; Miners, John Oliver; Brennan, James M; Knights, Kathleen Mary
2008In vitro characterisation of human renal and hepatic frusemide glucuronidation and identification of the UDP-glucuronosyltransferase enzymes involved in this pathwayKerdpin, Oranun; Knights, Kathleen Mary; Elliot, David John; Miners, John Oliver
2010The In Vitro Characterization of Inhibitory Drug-Drug Interactions Involving UDP-GlucuronosyltransferaseMiners, John Oliver; Polasek, Thomas Metodey; Mackenzie, Peter Ian; Knights, Kathleen Mary
2006In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: Pitfalls and promisesMiners, John Oliver; Knights, Kathleen Mary; Houston, J Brian; Mackenzie, Peter Ian
2007In vitro-in vivo extrapolation of drug glucuronidation kinetic parameters: Pitfalls and PromisesMiners, John Oliver; Rowland, Andrew; Uchaipichat, Verawan Nu; Elliot, David John; Knights, Kathleen Mary; Galetin, A; Houston, J Brian; Mackenzie, Peter Ian
2006Non-selective nonsteroidal anti-inflammatory drugs and cardiovascular events: is aldosterone the silent partner in crime?Knights, Kathleen Mary; Mangoni, Arduino Aleksander; Miners, John Oliver
2010Non-steroidal anti-inflammatory drugs and atherothrombotic risk in older patients: where do we stand?Mangoni, Arduino Aleksander; Reid, David M; Knights, Kathleen Mary
2005Novel mechanisms of nonsteroidal anti-inflammatory drug-induced renal toxicityKnights, Kathleen Mary; Miners, John Oliver; Tsoutsikos, Voula
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