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Browsing by Author Mackenzie, Peter Ian

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PreviewIssue DateTitleAuthor(s)
2008The "albumin effect" and drug glucuronidation: bovine serum albumin and fatty acid-free human serum albumin enhance the glucuronidation of UDP-glucuronosyltransferase (UGT) 1A9 substrates but not UGT1A1 and UGT1A6 activitiesMackenzie, Peter Ian; Miners, John Oliver; Knights, Kathleen Mary; Rowland, Andrew
2008The "Albumin Effect" and in Vitro-in Vivo Extrapolation: Sequestration of Long-Chain Unsaturated Fatty Acids Enhances Phenytoin Hydroxylation by Human Liver Microsomal and Recombinant Cytochrome P450 2C9Mackenzie, Peter Ian; Miners, John Oliver; Rowland, Andrew; Elliot, David John; Knights, Kathleen Mary
Feb-2014Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: different susceptibility for UGT isoforms and UGT1A1/7 variants.Ishii, Y; Koba, H; Kinoshita, K; Oizaki, T; Iwamoto, Y; Takeda, S; Miyauchi, Y; Nishimura, Y; Egoshi, N; Taura, F; Morimoto, S; Ikushiro, S; Nagata, K; Yamazoe, Y; Mackenzie, Peter Ian; Yamada, H
2007Amino terminal domains of human UDP-glucuronosyltransferases (UGT) 2B7 and 2B15 associated with substrate selectivity and autoactivationLewis, Benjamin Cavell; Mackenzie, Peter Ian; Elliot, David John; Burchell, Brian; Bhasker, Ramana; Miners, John Oliver
2007Binding of inhibitory fatty acids is responsible for the enhancement of UDP-Glucuronosyltransferase 2B7 activity by albumin: implications for in vitro-in vivo extrapolationRowland, Andrew; Miners, John Oliver; Gaganis, Paraskevi; Elliot, David John; Mackenzie, Peter Ian; Knights, Kathleen Mary
2007Carboxylic Acid Drug-Induced DNA Nicking in HEK293 Cells Expressing Human UDP-Glucuronosyltransferases: Role of Acyl Glucuronide Metabolites and Glycation PathwaysMackenzie, Peter Ian; DeGraaf, Yvette; Southwood, H; Burcham, P; Miners, John Oliver; Sallustio, B
2006The caudal-related homeodomain protein Cdx2 and hepatocyte nuclear factor 1-alpha cooperatively regulate the UDP-glucuronosyltransferase 2B7 gene promotorGregory, Philip A;