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Browsing by Author Miners, John Oliver

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PreviewIssue DateTitleAuthor(s)
2010AFM study of the interaction of cytochrome P450 2C9 with phospholipid bilayersMiners, John Oliver; Lewis, Benjamin Cavell; Sykes, Matthew James; Shapter, Joseph George; Nussio, Matthew Robert; Voelcker, Nicolas Hans
2008The "albumin effect" and drug glucuronidation: bovine serum albumin and fatty acid-free human serum albumin enhance the glucuronidation of UDP-glucuronosyltransferase (UGT) 1A9 substrates but not UGT1A1 and UGT1A6 activitiesMackenzie, Peter Ian; Miners, John Oliver; Knights, Kathleen Mary; Rowland, Andrew
2008The "Albumin Effect" and in Vitro-in Vivo Extrapolation: Sequestration of Long-Chain Unsaturated Fatty Acids Enhances Phenytoin Hydroxylation by Human Liver Microsomal and Recombinant Cytochrome P450 2C9Mackenzie, Peter Ian; Miners, John Oliver; Rowland, Andrew; Elliot, David John; Knights, Kathleen Mary
2009Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: Inhibition by NSAIDsKnights, Kathleen Mary; Winner, Leanne; Elliot, David John; Bowalgaha, Kushari; Miners, John Oliver
2007Amino acid conjugation: contribution to the metabolism and toxicity of xenobiotic carboxylic acidsKnights, Kathleen Mary; Sykes, Matthew James; Miners, John Oliver
2007Amino terminal domains of human UDP-glucuronosyltransferases (UGT) 2B7 and 2B15 associated with substrate selectivity and autoactivationLewis, Benjamin Cavell; Mackenzie, Peter Ian; Elliot, David John; Burchell, Brian; Bhasker, Ramana; Miners, John Oliver
2009Assessment of inter-individual variability in predicted phenytoin clearancePolasek, Thomas Metodey; Polak, Sebastian; Doogue, Matthew Philip; Rostami-Hodjegan, Amin; Miners, John Oliver
2007Binding of inhibitory fatty acids is responsible for the enhancement of UDP-Glucuronosyltransferase 2B7 activity by albumin: implications for in vitro-in vivo extrapolationRowland, Andrew; Miners, John Oliver; Gaganis, Paraskevi; Elliot, David John; Mackenzie, Peter Ian; Knights, Kathleen Mary
2007Carboxylic Acid Drug-Induced DNA Nicking in HEK293 Cells Expressing Human UDP-Glucuronosyltransferases: Role of Acyl Glucuronide Metabolites and Glycation PathwaysMackenzie, Peter Ian; DeGraaf, Yvette; Southwood, H; Burcham, P; Miners, John Oliver; Sallustio, B
2007Characterisation of the Binding of Cationic Amphiphilic Drugs to Phospholipid Bilayers using Surface Plasmon ResonanceShapter, Joseph George; Sykes, Matthew James; Miners, John Oliver; Nussio, Matthew Robert
2006Characterization of chloropromazine binding to lipid bilayer membranesNussio, Matthew Robert; Sykes, Matthew James; Shapter, Joseph George; Miners, John Oliver
2009Characterization of the Binding of Drugs to Human Intestinal Fatty Acid Binding Protein (IFABP): Potential Role of IFABP as an Altenative to Albumin for in Vitro-in Vivo Extrapolation of Drug Kinetic ParametersRowland, Andrew; Knights, Kathleen Mary; Mackenzie, Peter Ian; Miners, John Oliver
2007Comparative homology modeling of human cytochrome P4501A1 (CYP1A1) and confirmation of residues involved in 7-ethoxyresorufin O-deethylation by site-directed mutagenesis and enzyme kinetic analysisMiners, John Oliver; Lewis, Benjamin Cavell; Mackenzie, Peter Ian
2003Comparison of linear and nonlinear classification algorithms for the prediction of drug and chemical metabolism by human UDP-glucuronosyltransferase isoforms.Winkler, D A; Smith, Paul Alexander; Miners, John Oliver; Burden, F R; McKinnon, Ross A; Sorich, Michael J
2008The configuration of the 17-hydroxy group variably influences the glucuronidation of B-estradiol and epiestradiol by human UDP-GlucuronosyltransferasesItaaho, Katrina; Mackenzie, Peter Ian; Ikushiro, Shin-ichi; Miners, John Oliver; Finel, Moshe
2007Critical roles of residues 36 and 40 in the phenol and tertiary amine aglycone substrate selectivities of UDP-glucuronosyltransferases 1A3 and 1A4Kubota, Takahiro; Mackenzie, Peter Ian; Miners, John Oliver; Lewis, Benjamin Cavell; Elliot, David John
2010Defining the COX inhibitor selectivity of NSAIDS: implications for understanding toxicityKnights, Kathleen Mary;