DSpace Community: http://hdl.handle.net/2328/1527 2013-05-25T16:53:02Z 2013-05-25T16:53:02Z Genomic instability in scleroderma Walker, Jennifer Gauld Turner, David Richard Shen, Xiaofeng Roberts-Thomson, Peter John Smith, Malcolm Douglas Male, D A Ahern, Michael John Cox, Sally Rebecca http://hdl.handle.net/2328/10229 2013-05-13T01:37:50Z 2004-01-01T00:00:00Z Title: Genomic instability in scleroderma Authors: Walker, Jennifer Gauld; Turner, David Richard; Shen, Xiaofeng; Roberts-Thomson, Peter John; Smith, Malcolm Douglas; Male, D A; Ahern, Michael John; Cox, Sally Rebecca 2004-01-01T00:00:00Z The use of the hand anatomic index to assess deformity and impaired function in systemic sclerosis. [Postprint] Roberts-Thomson, A J Massy-Westropp, Nicola Smith, Malcolm Douglas Ahern, Michael John Highton, J Roberts-Thomson, Peter John http://hdl.handle.net/2328/1530 2013-05-13T01:27:10Z 2006-03-01T00:00:00Z Title: The use of the hand anatomic index to assess deformity and impaired function in systemic sclerosis. [Postprint] Authors: Roberts-Thomson, A J; Massy-Westropp, Nicola; Smith, Malcolm Douglas; Ahern, Michael John; Highton, J; Roberts-Thomson, Peter John Abstract: To determine the "hand anatomic index" (HAI-a quantitative measure of hand deformity) in systemic sclerosis (scleroderma) and to compare it with the other measures of hand deformity and functional impairment. The HAI (measure of open hand span minus closed hand span/lateral height of hand) was determined in 30 patients with scleroderma and compared with hand deformity (as assessed by two independent rheumatologists) and with the Health Assessment Questionnaire (mHAQ), hand strength and prehensile gripability data. The HAI was confirmed as a reliable measure which clearly distinguished patients with increasing hand deformity and separated patients with diffuse scleroderma (n=12) from limited scleroderma (n=18), P=0.005. The HAI correlated significantly with measures of global functional impairment (as measured by the mHAQ) r=-0.46, P=0.01, hand strength r=0.51, P=0.0001 and prehensile gripability, r=-0.37, P=0.05 but neither with disease duration r=-0.16, P=NS nor age at disease onset r=0.20, P=NS. It was estimated that the HAI accounts for ~25% of the total global disability (as measured by HAQ). Measurement of the HAI in scleroderma provides a reliable and objective measure reflecting variable degrees of hand deformity and functional impairment and might provide a valid clinical outcome measure in patients with this disabling disorder. 2006-03-01T00:00:00Z Microchimerism in systemic sclerosis: comment on the article by Johnson et al.[comment]. [Postprint] Roberts-Thomson, Peter John Walker, Jennifer Gauld Hakendorf, Paul Haylett Smith, Malcolm Douglas Ahern, Michael John http://hdl.handle.net/2328/1529 2013-05-13T01:27:07Z 2002-09-01T00:00:00Z Title: Microchimerism in systemic sclerosis: comment on the article by Johnson et al.[comment]. [Postprint] Authors: Roberts-Thomson, Peter John; Walker, Jennifer Gauld; Hakendorf, Paul Haylett; Smith, Malcolm Douglas; Ahern, Michael John Abstract: Comment in response to Arthritis Rheum. 2001 Aug;44(8):1848-54 2002-09-01T00:00:00Z