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Please use this identifier to cite or link to this item: http://hdl.handle.net/2328/1697

Title: Detection of Tropheryma whippelii DNA in a patient with AIDS
Authors: Maiwald, Matthias
Meier-Willersen, HJ
Hartmann, M
von Herbay, Axel
Keywords: AIDS-Related Opportunistic Infections
Actinomycetales Infections
DNA, Bacterial
Molecular Sequence Data
Polymerase Chain Reaction
RNA, Bacterial
RNA, Ribosomal, 16S
Whipple Disease
Issue Date: May-1995
Publisher: American Society for Microbiology
Citation: Maiwald, M. Meier-Willersen, H.J. Hartmann, M. 1995 Detection of Tropheryma whippelii DNA in a patient with AIDS, 'Journal of Clinical Microbiology', Vol. 33, No. 5., 1354-6
Abstract: A case of an AIDS patient infected with the Whipple's disease bacterium, Tropheryma whippelii, is reported. A DNA fragment with sequence specificity for the 16S rRNA gene of the bacterium was detected by PCR in a duodenal biopsy specimen from a 55-year-old male patient with AIDS and diarrhea. The biopsy specimen contained periodic acid-Schiff stain-positive macrophages which did not, however, resemble the sickleform-particle-containing cells characteristic of Whipple's disease. This observation raises two possibilities: either the patient had a coincidence of AIDS and Whipple's disease or Tropheryma whippelii acted as an opportunistic pathogen in this immunodeficient patient. The latter explanation is of interest in light of the ongoing discussion of immunologic abnormalities as predisposing factors for Whipple's disease.
URI: http://hdl.handle.net/2328/1697
ISSN: 0095-1137
Appears in Collections:Matthias Maiwald

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