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Please use this identifier to cite or link to this item: http://hdl.handle.net/2328/1699

Title: Organization, structure, and variability of the rRNA operon of the Whipple's disease bacterium (Tropheryma whippelii).
Authors: Maiwald, Matthias
von Herbay, Axel
Lepp, PW
Relman, David A
Keywords: Actinomycetales
Molecular Sequence Data
Nucleic Acid Conformation
Operon
Phylogeny
RNA, Ribosomal
Whipple Disease
Issue Date: Jun-2000
Publisher: American Society for Microbiology
Citation: Maiwald, M. von Herbay, A. Lepp, PW. Relman, DA. 2000 Organization, structure, and variability of the rRNA operon of the Whipple's disease bacterium (Tropheryma whippelii)., 'Journal of Bacteriology', Vol. 182, No. 11., 3292-7
Abstract: Whipple's disease is a systemic disorder associated with a cultivation-resistant, poorly characterized actinomycete, Tropheryma whippelii. We determined a nearly complete rRNA operon sequence of T. whippelii from specimens from 3 patients with Whipple's disease, as well as partial operon sequences from 43 patients. Variability was observed in the 16S-23S rRNA spacer sequences, leading to the description of five distinct sequence types. One specimen contained two spacer sequence types, raising the possibility of a double infection. Secondary structure models for the primary rRNA transcript and mature rRNAs revealed rare or unique features.
URI: http://hdl.handle.net/2328/1699
ISSN: 0021-9193
Appears in Collections:Matthias Maiwald

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