Flinders Academic Commons >
Research Publications >
01 - Physical, Chemical and Earth Sciences >
0303 - Macromolecular and Materials Chemistry >
Please use this identifier to cite or link to this item:
|Title: ||Switchable surface coatings for control over
|Authors: ||Voelcker, Nicolas Hans|
Cole, Martin Ashley
Griesser, Hans J
Thissen, Helmut Werner
|Issue Date: ||2007|
|Citation: ||Cole, M., Jasieniak, M., Voelcker, N.H.,
Thissen, H.W., Horn, R., & Griesser, H.J., 2007. Switchable surface coatings for
control over protein adsorption. Proceedings of SPIE: The International Society for
Optical Engineering, 6416(641606), 1-10.|
|Abstract: ||Control over biomolecule interactions at interfaces is becoming an increasingly important goal for a range of scientific
fields and is being intensively studied in areas of biotechnological, biomedical and materials science. Improvement in the
control over materials and biomolecules is particularly important to applications such as arrays, biosensors, tissue
engineering, drug delivery and 'lab on a chip' devices. Further development of these devices is expected to be achieved
with thin coatings of stimuli responsive materials that can have their chemical properties 'switched' or tuned to stimulate
a certain biological response such as adsorptionldesorption of proteins. Switchable coatings show great potential for the
realisation of spatial and temporal immobilisation of cells and biomolecules such as DNA and proteins.
This study focuses on protein adsorption onto coatings of the thermosensitive polymer poly(N-isopropylacrylamide)
(pNIPAM) which can exhibit low and high protein adsorption properties based on its temperature dependent
conformation. At temperatures above its lower critical solution temperature (LCST) pNIPAM polymer chains are
collapsed and protein adsorbing whilst below the LCST they are hydrated and protein repellent.
Coatings of pNIPAM on silicon wafers were prepared by free radical polymerisation in the presence of surface bound
polymerisable groups. Surface analysis and protein adsorption was carried out using X-ray photoelectron spectroscopy,
time of flight secondary ion mass spectrometry and contact angle measurements.
This study is expected to aid the development of stimuli-responsive coatings for biochips and biodevices.|
|Appears in Collections:||0303 - Macromolecular and Materials Chemistry|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.