College of Medicine and Public Health
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The College of Medicine and Public Health deliver clinical, population and lab based research, integrated teaching programs and high quality clinical services.
Our teaching footprint reaches out from our world class teaching hospital at the Flinders Medical Centre in South Australia to multiple rural clinical locations all the way to Darwin in the Northern Territory.
We promote research in health services, systems improvements, public and population health, improved clinical care and laboratory and precision medicine.
This approach has seen us investigate everything from community health problems to the smallest of molecules that influence human disease.
Our research and teaching equips the next generation of leaders and innovators with the skill, commitment and vision to protect vulnerable communities and truly advance health outcomes. It’s at the heart of everything we do.
It’s about improving the health and wellbeing for everyone in society.
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Recent Submissions
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Interventions targeting the prescribing and monitoring of vancomycin for hospitalized patients: a systematic review with meta-analysis
(Dove Press, 2018-10-31)Purpose: Vancomycin prescribing requires individualized dosing and monitoring to ensure efficacy, limit toxicity, and minimize resistance. Although there are nationally endorsed guidelines from several countries addressing ... -
A data-driven, knowledge-based approach to biomarker discovery: application to circulating microRNA markers of colorectal cancer prognosis
(Springer Nature Publishing AG, 2018-06-01)Recent advances in high-throughput technologies have provided an unprecedented opportunity to identify molecular markers of disease processes. This plethora of complex-omics data has simultaneously complicated the problem ... -
Sustained improvement in vancomycin dosing and monitoring post-implementation of guidelines: Results of a three-year follow-up after a multifaceted intervention in an Australian teaching hospital
(Elsevier, 2018-02)Introduction Despite vancomycin being in use for over half-a-century, it is still not dosed or monitored appropriately in many centers around the world. The objective of this study was to determine the effectiveness of ... -
Adherence to antibiotic guidelines and reported penicillin allergy: pooled cohort data on prescribing and allergy documentation from two English National Health Service (NHS) trusts
(BMJ Publishing group, 2019-03-01)Objective To investigate documentation of antimicrobial allergy and to determine prescribing adherence to local antibiotic guidelines for inpatients with and without reported penicillin allergy treated for infection in a ... -
Burkholderia lata Infections from Intrinsically Contaminated Chlorhexidine Mouthwash, Australia, 2016
(Centers for Disease Control and Prevention, 2018-11)Burkholderia lata was isolated from 8 intensive care patients at 2 tertiary hospitals in Australia. Whole-genome sequencing demonstrated that clinical and environmental isolates originated from a batch of contaminated ... -
Monte Carlo Simulations Demonstrate Algorithmic Interventions Over Time Reduce Hospitalisation in Patients With Schizophrenia and Bipolar Disorder
(Sage Journals, 2018-10-02)Non-adherence with pharmacologic treatment is associated with increased rates of relapse and rehospitalisation among patients with schizophrenia and bipolar disorder. To improve treatment response, remission, and recovery, ... -
C-Reactive Protein: Higher During Acute Psychotic Episodes and Related to Cortical Thickness in Schizophrenia and Healthy Controls
(Frontiers, 2018-10-10)There is increasing evidence for the role of inflammation in schizophrenia, yet the stability of increased peripheral inflammation in acute psychosis and the degree to which peripheral inflammation relates to cortical ... -
Mechanisms Underlying Overactive Bladder and Interstitial Cystitis/Painful Bladder Syndrome
(Frontiers, 2018-12-12)The bladder is innervated by extrinsic afferents that project into the dorsal horn of the spinal cord, providing sensory input to the micturition centers within the central nervous system. Under normal conditions, the ... -
Immunological failure in HIV-infected adults from 2003 to 2015 in Southwest Ethiopia: a retrospective cohort study
(BMJ Publishing group, 2018-07-10)Objective To assess the prevalence, trend and associated factors for immunological failure (IF), and the magnitude of antiretroviral therapy (ART) shift among adults infected with HIV in Southwest Ethiopia. Setting A ... -
Risk Factors for Severe Diarrhea with an Afatinib Treatment of Non-Small Cell Lung Cancer: A Pooled Analysis of Clinical Trials
(MDPI, 2018-10-15)Afatinib is an effective therapy for metastatic non-small cell lung cancer (NSCLC) but it is associated with a relatively high incidence of severe diarrhea. The association between pre-treatment candidate predictors (age, ... -
Editorial: Current Perspectives on Insulin-Like Growth Factor Binding Protein (IGFBP) Research
(Frontiers, 2018-11-20)The insulin-like growth factor binding proteins (IGFBPs), as high affinity IGF binding partners, are the principal regulators of IGF-1 and IGF-2 action. Accordingly, effects of IGFBPs can be observed on the levels of growth ... -
Guideline-indicated treatments and diagnostics, GRACE risk score, and survival for non-ST elevation myocardial infarction
(Oxford University Press, 2018-08-13)Aims To investigate whether improved survival from non-ST-elevation myocardial infarction (NSTEMI), according to GRACE risk score, was associated with guideline-indicated treatments and diagnostics, and persisted after ... -
Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
(Elsevier, 2018-09-19)Background Lower respiratory infections are a leading cause of morbidity and mortality around the world. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study 2016, provides an up-to-date analysis of the ... -
Hypertension Status and Associations with Self-Rated Health and General Practitioner Health Seeking in a Rural Australian Cohort
(MDPI, 2018-11-06)Hypertension is the most frequently managed condition by Australian general practitioners (GP). Knowledge of hypertension and blood pressure (BP) values may motivate individuals to seek GP management. Our study aims to ... -
Societal determinants of HIV vulnerability among clients of female commercial sex workers in Indonesia
(Public Library of Science, 2018-11-21)This study aimed to explore societal determinants of HIV vulnerability among the clients of female commercial sex workers (FCSWs) in Belu and Malaka districts, Indonesia. A qualitative inquiry using in-depth interviews was ... -
Single-Cell Profiling Identifies Key Pathways Expressed by iPSCs Cultured in Different Commercial Media
(Elsevier, 2018-09-28)We assessed the pluripotency of human induced pluripotent stem cells (iPSCs) maintained on an automated platform using StemFlex and TeSR-E8 media. Analysis of transcriptome of single cells revealed similar expression of ... -
Pharmacogenomics of CYP2C9: Functional and Clinical Considerations
(MDPI, 2017-12-28)CYP2C9 is the most abundant CYP2C subfamily enzyme in human liver and the most important contributor from this subfamily to drug metabolism. Polymorphisms resulting in decreased enzyme activity are common in the CYP2C9 ... -
Novel Bacterial Cellulose-Poly (Acrylic Acid) Hybrid Hydrogels with Controllable Antimicrobial Ability as Dressings for ChronicWounds
(MDPI, 2018-11-28)This investigation examines the combination of poly (acrylic acid) (PAA) and bacterial cellulose (BC) nanofibers to synthesize hydrogel hybrid composites used for wound dressing application. Amoxicillin (AM) was also grafted ... -
Can reducing sitting time in the university setting improve the cardiometabolic health of college students?
(Dove Press, 2018-08-15)Purpose: The high prevalence of metabolic syndrome (MetS), prediabetes, and increased risk of cardiovascular diseases linked with prolonged sitting has created a need to identify options to limit sedentary behaviors. A ... -
Spinal Afferent Innervation of the Colon and Rectum
(MDPI, 2018-12-04)Despite their seemingly elementary roles, the colon and rectum undertake a variety of key processes to ensure our overall wellbeing. Such processes are coordinated by the transmission of sensory signals from the periphery ...
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