Browsing National Health and Medical Research Council (NHMRC) by Issue Date
Now showing items 1-20 of 363
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Effects of amino acid substitutions at positions 33 and 37 on UDP-glucuronosyltransferase 1A9 (UGT1A9) activity and substrate selectivity
(Elsevier, Dec-12)UGT1A9 contributes to the glucuronidation of numerous drugs and xenobiotics. There is evidence to suggest that the Met33Thr substitution, as occurs in the polymorphic variant UGT1A9*3, variably affects xenobiotic ... -
Secreted human Ro52 autoantibody proteomes express a restricted set of public clonotypes
(Elsevier, Dec-12)Long-lived secreted autoantibody responses in systemic autoimmunity are generally regarded to be polyclonal and to express a diverse B-cell repertoire. Here, we have used a proteomic approach based on de novo sequencing ... -
Preproglucagon neurons innervate neurochemically identified autonomic neurons in the mouse brainstem
(Elsevier, Jan-13)Preproglucagon (PPG) neurons produce glucagon-like peptide-1 (GLP-1) and occur primarily in the nucleus tractus solitarius (NTS). GLP-1 affects a variety of central autonomic circuits, including those controlling the ... -
Long-term Ro60 humoral autoimmunity in primary Sjogren's syndrome is maintained by rapid clonal turnover
(Elsevier, Jul-13)Long-term humoral autoimmunity to RNA–protein autoantigens is considered a hallmark of systemic autoimmune diseases. We use high resolution Orbitrap mass spectrometric autoantibody sequencing to track the evolution of a ... -
The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification
(Elsevier, Jun-13)Human UDP-glucuronosyltransferase (UGT) exists as a superfamily of 22 proteins, which are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of the UGT1A and 2B subfamilies play a key role ... -
Whose values in health? An empirical comparison of the application of adolescent and adult values for the CHU9D and AQOL-6D in the Australian adolescent general population
(Elsevier, 11/06/2012)The Child Health Utility-9D (CHU-9D) and the Assessment of Quality of Life-6D (AQOL-6D) presently represent the only two generic preference-based instruments developed for application with young people with both adult- and ... -
Work organisation, job insecurity and occupational health disparities
(Wiley-Blackwell, 16/10/2012)Changes in employment conditions in the global economy over the past 30 years have led to increased job insecurity and other work organization hazards. These hazards may play a role in creating and sustaining occupational ... -
Selective expression of α-synuclein-immunoreactivity in vesicular acetylcholine transporter-immunoreactive axons in the guinea-pig rectum and human colon
(Wiley-Blackwell, 17/12/2013)Parkinson's disease is a neurodegenerative disorder characterized by motor and nonmotor impairments, including constipation. The hallmark pathological features of Parkinson's disease are Lewy bodies and neurites, of which ... -
Viscerofugal neurons recorded from guinea-pig colonic nerves after organ culture
(Wiley-Blackwell, 19/07/2012)Background Enteric viscerofugal neurons provide cholinergic synaptic inputs to prevertebral sympathetic neurons, forming reflex circuits that control motility and secretion. Extracellular recordings of identified viscerofugal ... -
Socio-demographic and work setting correlates of poor mental health in a population sample of working Victorians: application in evidence-based intervention priority setting
(Taylor and Francis, 2/07/2012)Interventions to promote mental health in the workplace are rapidly gaining acceptability as a means to prevent, screen, treat and effectively manage the growing disease burden of depression and anxiety among working people. ... -
The impact of corneal allograft rejection on the long-term outcome of corneal transplantation
(2005)To examine the influence of corneal allograft rejection on the survival of penetrating corneal transplantation, to review the status of conventional therapies to improve graft survival, and to consider prospects for ... -
Rejection and acceptance of corneal allografts
(Lippincott, Williams & Wilkins, 2009)PURPOSE OF REVIEW: Corneal transplantation is successful in the short-term, but the long-term prognosis has not improved over the past 20 years. Here, we review recent findings that may contribute to improved corneal ... -
Determining the repertoire of IGH gene rearrangements in order to develop molecular markers for minimal residual disease in acute lymphoblastic leukemia
(Elsevier, 2009)Molecular markers for minimal residual disease in B-lineage acute lymphoblastic leukemia were identified by determining, at the time of diagnosis, the repertoire of rearrangements of the immunoglobulin heavy chain (IGH) ... -
Sensitive and specific measurement of minimal residual disease in acute lymphoblastic leukaemia
(Elsevier, 2009-05)A sensitive and specific quantitative real-time polymerase chain reaction method, involving three rounds of amplification with two allele-specific oligonucleotide primers directed against an rearrangement, was developed ... -
The Influence of Rejection Episodes in Recipients of Bilateral Corneal Grafts
(2010)We investigated whether a rejection episode in one graft was associated with rejection in the other graft, in recipients with bilateral corneal transplants. In a prospectively maintained, national register of 14 ... -
EEG spindles in the rat: Evidence for a synchronous network phenomenon
(Elsevier, 2010) -
Sacro-lumbar Intersegmental Spinal Reflex in Autonomic Pathways Mediating Female Sexual Function
(John Wiley & Sons Ltd, 2011) -
Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1
(Nature Publishing Group, 2011)A genome-wide association study (GWAS) for open angle glaucoma (OAG) blindness was conducted using a discovery cohort of 590 cases with severe visual field loss and 3956 controls. Genome-wide significant associations were ... -
The outcome of corneal transplantation in infants, children, and adolescents
(Elsevier, 2011)OBJECTIVE: To examine factors affecting penetrating corneal graft survival and visual outcomes in patients aged less than 20 years. DESIGN: Large prospective, cohort study. PARTICIPANTS: Records of 14 865 followed ...