Browsing National Health and Medical Research Council (NHMRC) by Issue Date

Secreted human Ro52 autoantibody proteomes express a restricted set of public clonotypes

Arentz, Georgia; Thurgood, Lauren Alexandra; Lindop, Rhianna; Chataway, Timothy Kennion; Gordon, Thomas Paul (Elsevier, Dec-12)

Long-lived secreted autoantibody responses in systemic autoimmunity are generally regarded to be polyclonal and to express a diverse B-cell repertoire. Here, we have used a proteomic approach based on de novo sequencing ...

Effects of amino acid substitutions at positions 33 and 37 on UDP-glucuronosyltransferase 1A9 (UGT1A9) activity and substrate selectivity

Korprasertthaworn, Porntipa; Rowland, Andrew; Lewis, Benjamin Cavell; Mackenzie, Peter Ian; Yoovathaworn, Krontong; Miners, John Oliver (Elsevier, Dec-12)

UGT1A9 contributes to the glucuronidation of numerous drugs and xenobiotics. There is evidence to suggest that the Met33Thr substitution, as occurs in the polymorphic variant UGT1A9*3, variably affects xenobiotic ...

Preproglucagon neurons innervate neurochemically identified autonomic neurons in the mouse brainstem

Llewellyn-Smith, Ida Jonassen; Gnanamanickam, Greta J E; Reimann, Frank; Gribble, Fiona M; Trapp, Stefan (Elsevier, Jan-13)

Preproglucagon (PPG) neurons produce glucagon-like peptide-1 (GLP-1) and occur primarily in the nucleus tractus solitarius (NTS). GLP-1 affects a variety of central autonomic circuits, including those controlling the ...

Long-term Ro60 humoral autoimmunity in primary Sjogren's syndrome is maintained by rapid clonal turnover

Lindop, Rhianna; Arentz, Georgia; Bastian, Isabell; Whyte, Andrew F; Thurgood, Lauren Alexandra; Chataway, Timothy Kennion; Jackson, Michael W; Gordon, Thomas Paul (Elsevier, Jul-13)

Long-term humoral autoimmunity to RNA–protein autoantigens is considered a hallmark of systemic autoimmune diseases. We use high resolution Orbitrap mass spectrometric autoantibody sequencing to track the evolution of a ...

Whose values in health? An empirical comparison of the application of adolescent and adult values for the CHU9D and AQOL-6D in the Australian adolescent general population

Ratcliffe, Julie; Stevens, Katherine; Flynn, Terry; Brazier, John; Sawyer, Michael G (Elsevier, 11/06/2012)

The Child Health Utility-9D (CHU-9D) and the Assessment of Quality of Life-6D (AQOL-6D) presently represent the only two generic preference-based instruments developed for application with young people with both adult- and ...

Work organisation, job insecurity and occupational health disparities

Landsbergis, PA; Grzywacz, JG; LaMontagne, Anthony D (Wiley-Blackwell, 16/10/2012)

Changes in employment conditions in the global economy over the past 30 years have led to increased job insecurity and other work organization hazards. These hazards may play a role in creating and sustaining occupational ...

Selective expression of α-synuclein-immunoreactivity in vesicular acetylcholine transporter-immunoreactive axons in the guinea-pig rectum and human colon

Sharrad, DF; de Vries, E; Brookes, Simon Jonathan (Wiley-Blackwell, 17/12/2012)

Parkinson's disease is a neurodegenerative disorder characterized by motor and nonmotor impairments, including constipation. The hallmark pathological features of Parkinson's disease are Lewy bodies and neurites, of which ...

Viscerofugal neurons recorded from guinea-pig colonic nerves after organ culture

Hibberd, TJ; Zagorodnyuk, Vladimir Petrovich; Spencer, Nicholas John; Brookes, Simon Jonathan (Wiley-Blackwell, 19/07/2012)

Background Enteric viscerofugal neurons provide cholinergic synaptic inputs to prevertebral sympathetic neurons, forming reflex circuits that control motility and secretion. Extracellular recordings of identified viscerofugal ...

Socio-demographic and work setting correlates of poor mental health in a population sample of working Victorians: application in evidence-based intervention priority setting

LaMontagne, Anthony D; D'Souza, Rennie M; Shann, Clare B (Taylor and Francis, 2/07/2012)

Interventions to promote mental health in the workplace are rapidly gaining acceptability as a means to prevent, screen, treat and effectively manage the growing disease burden of depression and anxiety among working people. ...

The impact of corneal allograft rejection on the long-term outcome of corneal transplantation

Coster, Douglas John; Williams, Keryn Anne (2005)

To examine the influence of corneal allograft rejection on the survival of penetrating corneal transplantation, to review the status of conventional therapies to improve graft survival, and to consider prospects for ...

Central sleep apnea on commencement of continuous positive airway pressure in patients with a primary diagnosis of obstructive sleep apnea-hypopnea

Antic, Nicholas Alexander; Catcheside, Peter G; Mercer, Jeremy; McEvoy, Ronald Douglas; Lehman, Sam; Thompson, Courtney Cie (2007)

Determining the repertoire of IGH gene rearrangements in order to develop molecular markers for minimal residual disease in acute lymphoblastic leukemia

Brisco, Michael; Latham, Susan Elizabeth; Sutton, Rosemary; Hughes, Elizabeth; Wilczek, Vicki Jane; van Zanten, Katrina; Budgen, Bradley John; Bahar, Anita Y; Malec, Maria; Kuss, Bryone Jean; Waters, Keith; Venn, Nicola C; Giles, Jodie E; Haber, Michelle; Norris, Murray D; Marshall, Glenn M; Morley, Alexander Alan; Sykes, Pamela Joy (Elsevier, 2009)

Molecular markers for minimal residual disease in B-lineage acute lymphoblastic leukemia were identified by determining, at the time of diagnosis, the repertoire of rearrangements of the immunoglobulin heavy chain (IGH) ...

Rejection and acceptance of corneal allografts

Klebe, Sonja; Coster, Douglas John; Williams, Keryn Anne (Lippincott, Williams & Wilkins, 2009)

PURPOSE OF REVIEW: Corneal transplantation is successful in the short-term, but the long-term prognosis has not improved over the past 20 years. Here, we review recent findings that may contribute to improved corneal ...

Sensitive and specific measurement of minimal residual disease in acute lymphoblastic leukaemia

Morley, Alexander Alan; Latham, Susan Elizabeth; Brisco, Michael; Sykes, Pamela J; Sutton, Rosemary; Hughes, Elizabeth; Wilczek, Vicki Jane; Budgen, Bradley John; van Zanten, Katrina; Kuss, Bryone Jean; Venn, Nicola C; Norris, Murray D; Crock, Catherine; Storey, Colin; Waters, Keith; Revesz, Tamas (Elsevier, 2009-05)

A sensitive and specific quantitative real-time polymerase chain reaction method, involving three rounds of amplification with two allele-specific oligonucleotide primers directed against an rearrangement, was developed ...