Browsing National Health and Medical Research Council (NHMRC) by Title
Now showing items 1-20 of 362
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5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT
(Frontiers, 2013-08)Recent studies have shown that endogenous serotonin is not required for colonic peristalsis in vitro, nor gastrointestinal (GI) transit in vivo. However, antagonists of 5-Hydroxytryptamine (5-HT) receptors can inhibit ... -
Ablation of Barrett's oesophagus: towards improved outcomes for oesophageal cancer?
(John Wiley and Sons, 2012-09)Barrett's oesophagus is the major risk factor for oesophageal adenocarcinoma. The management of Barrett’s oesophagus entails treating reflux symptoms with acid-suppressing medication or surgery (fundoplication). However ... -
Accumulation of promutagenic DNA adducts in the mouse distal colon after consumption of heme does not induce colonic neoplasms in the western diet model of spontaneous colorectal cancer
(Wiley-Blackwell, 2013-10-01)Scope: Red meat is considered a risk factor for colorectal cancer (CRC). Heme is considered to promote colonic hyperproliferation and cell damage. Resistant starch (RS) is a food that ferments in the colon with studies ... -
Accurate Imputation-Based Screening of Gln368Ter Myocilin Variant in Primary Open-Angle Glaucoma
(Association for Research in Vision and Ophthalmology, 2015-08)PURPOSE: Myocilin (MYOC) is a well-established primary open-angle glaucoma (POAG) risk gene, with rare variants known to have high penetrance. The most common clinically relevant risk variant, Gln368Ter, has an allele ... -
Activation of intestinal spinal afferent endings by changes in intra‐mesenteric arterial pressure
(John Wiley & Sons, inc., 2015-06-25)KEY POINTS: A major class of mechano-nociceptors to the intestine have mechanotransduction sites on extramural and intramural arteries and arterioles ('vascular afferents'). These sensory neurons can be activated by ... -
Aggressive risk factor reduction study for atrial fibrillation and implications for the outcome of ablation: the ARREST-AF cohort study
(Elsevier, 2014-12-02)BACKGROUND: The long-term outcome of atrial fibrillation (AF) ablation demonstrates attrition. This outcome may be due to failure to attenuate the progressive substrate promoted by cardiovascular risk factors. OBJECT ... -
Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: different susceptibility for UGT isoforms and UGT1A1/7 variants.
(American Society for Pharmacology and Experimental Therapeutics (ASPET), 2014-02)Functional protein-protein interactions between UDP-glucuronosyltransferase (UGT)1A isoforms and cytochrome P450 (CYP)3A4 were studied. To this end, UGT1A-catalyzed glucuronidation was assayed in Sf-9 cells that simultaneously ... -
Ambivalence and its influence on participation and non-participation in screening for colorectal cancer
(SAGE, 2013-09)Colorectal cancer (CRC) is one of the most prevalent cancers worldwide, and an ideal target for early detection and prevention through cancer screening. Unfortunately, rates of participation in screening are less than ... -
Ambulatory models of care for obstructive sleep apnea: diagnosis and management
(Wiley-Blackwell, 2013-04-25)The high prevalence of obstructive sleep apnoea (OSA) and increasing awareness of its potential health consequences has placed significant pressure on laboratory-based sleep services leading to growing waiting lists and ... -
Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma
(Nature Publishing Group, 2018-02-18)Exfoliation syndrome (XFS) is the most common known risk factor for secondary glaucoma and a major cause of blindness worldwide. Variants in two genes, LOXL1 and CACNA1A, have previously been associated with XFS. To further ... -
Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity
(American Society for Clinical Investigation, 2016)Primary congenital glaucoma (PCG) is a devastating eye disease and an important cause of childhood blindness worldwide. In PCG, defects in the anterior chamber aqueous humor outflow structures of the eye result in elevated ... -
Anterior 90° partial vs Nissen fundoplication - 5 year follow-up of a single-centre randomised trial
(Springer-Verlag, 2012-09)Introduction Nissen fundoplication can be followed by side effects, and this has driven modifications, including partial fundoplications. We previously reported early outcomes from a randomised trial of Nissen vs anterior ... -
Argon plasma coagulation ablation versus endoscopic surveillance of Barrett’s oesophagus: late outcomes from two randomized trials.
(Georg Thieme Verlag, 2013-11)Introduction: Argon plasma coagulation (APC) has been used to ablate dysplastic and non-dysplastic Barrett’s esophagus. In this study we determined the longer term efficacy of APC ablation within two randomized controlled ... -
Ascending excitatory neural pathways modulate slow phasic myogenic contractions in the isolated human colon
(Wiley-Blackwell, 2013-05-01)Background In animal models, enteric reflex pathways have potent effects on motor activity; their roles have been much less extensively studied in human gut. The aim of this study was to determine if ascending excitatory ... -
Assessment of corneal thickness measurement using swept-source Fourier-domain anterior segment optical coherence tomography and Scheimpflug camera
(Elsevier, 2012-07-01)No abstract available -
Assessment of polygenic effects links primary open-angle glaucoma and age-related macular degeneration
(Nature Publishing Group, 2016)Primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD) are leading causes of irreversible blindness. Several loci have been mapped using genome-wide association studies. Until very recently, there ... -
Association of eNOS polymorphisms with primary angle-closure glaucoma
(Association for Research in Vision and Ophthalmology, 2013-03)Purpose: Recently, several studies have investigated genetic associations between Cytochrome P450 (CYP1B1), Endothelial nitric oxide synthase (eNOS) and Neurotrophin-4 (NTF4) with primary angle-closure glaucoma (PACG) in ... -
Association of genetic variants with primary angle closure glaucoma in two different populations
(Public Library of Science, 2013)PURPOSE: A recent large genome-wide association study (GWAS) identified multiple variants associated with primary angle-closure glaucoma (PACG). The present study investigated the role of these variants in two cohorts ...