Now showing items 1-3 of 3

    • A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome 

      Aung, Tin; Ozaki, Mineo; Mizoguchi, Takanori; Allingham, R Rand; Li, Zheng; Haripriya, Aravind; Nakano, Satoko; Uebe, Steffen; Harder, Jeffrey M; Chan, Anita S Y; Lee, Mei Chin; Burdon, Kathryn Penelope; Astakhov, Yury S; Abu-Amero, Khaled K; Zenteno, Juan C; Nilgun, Yildirim; Zarnowski, Tomasz; Pakravan, Mohammad; Safieh, Leen Abu; Ji, Liyun; Wang, Ya Xing; Williams, Susan; Paoli, Daniela; Schlottmann, Patricio G; Huang, Lulin; Sim, Kar Seng; Foo, Jia Nee; Nakano, Masakazu; Ikeda, Yoko; Kumar, Rajesh S; Ueno, Morio; Manabe, Shin-Ichi; Hayashi, Ken; Kazama, Shigeyasu; Ideta, Ryuichi; Mori, Yosai; Miyata, Kazunori; Sugiyama, Kazuhisa; Chuman, Hideki; Matsuda, Fumihiko; Yamashiro, Kenji; Gotoh, Norimoto; Miyake, Masahiro; Astakhov, Sergei Y; Osman, Essam A; Al-Obeidan, Saleh A; Owaidhah, Ohoud; Al-Jasim, Leyla; Shahwan, Sami; Fogarty, Rhys Daniel; Leo, Paul; Yetkin, Yaz; Oguz, Cilingir; Kanavi, Mozhgan; Mackey, David A; Hewitt, Alex W; Wellcome Trust Case Control Consortium; Craig, Jamie E (Nature Publishing Group, 2015-02-23)
      Exfoliation syndrome (XFS) is the most common recognizable cause of open-angle glaucoma worldwide. To better understand the etiology of XFS, we conducted a genome-wide association study (GWAS) of 1,484 cases and 1,188 ...
    • Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error 

      Fan, Qiao; Verhoeven, Virginie J M; Wojciechowski, Robert; Barathi, Veluchamy A; Hysi, Pirro; Guggenheim, Jeremy A; Hohn, Rene; Vitart, Veronique; Khawaja, Anthony; Yamashiro, Kenji; Hosseini, S Mohsen; Lehtimaki, Terho; Lu, Yi; Haller, Toomas; Xie, Jing; Delcourt, Cecile; Pirastu, Mario; Wedenoja, Juho; Gharahkhani, Puya; Venturini, Cristina; Miyake, Masahiro; Hewitt, Alex W; Guo, Xiaobo; Mazur, Johanna; Huffman, Jenifer E; Williams, Katie M; Polasek, Ozren; Campbell, Harry; Rudan, Igor; Vatavuk, Zoran; Wilson, James F; Joshi, Peter K; McMahon, George; St Pourcain, Beate; Evans, David M; Simpson, Claire L; Schwantes-An, Tae-Hwi; Igo, Robert P; Mirshahi, Alireza; Cougnard-Gregoire, Audrey; Bellenguez, Celine; Blettner, Maria; Raitakari, Olli; Kahonen, Mika; Seppala, Ilkka; Zeller, Tanja; Meitinger, Thomas; Ried, Janina S; Gieger, Christian; Portas, Laura; van Leeuwen, Elisabeth M; Amin, Najaf; Uitterlinden, Andre G; Rivadeneira, Fernando; Hofman, Albert; Vingerling, Johannes R; Wang, Ya Xing; Wang, Xu; Boh, Eileen Tai-Hui; Ikram, M Kamran; Sabanayagam, Charumathi; Gupta, Preeti; Tan, Vincent; Zhou, Lei; Ho, Candice E H; Lim, Wan'e; Craig, Jamie E; Burdon, Kathryn Penelope; Fogarty, Rhys Daniel; Consortium, Refractive Error and Myopia (CREAM); et. al. (Nature Publishing Group, 2016)
      Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium ...
    • New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics. 

      Springelkamp, Henriët; Iglesias, Adriana; Mishra, Aniket; Hohn, Rene; Wojciechowski, Robert; Khwaja, Anthony P; Nag, Abhishek; Wang, Ya Xing; Wang, Jie Jin; Cuellar-Partida, Gabriel; Gibson, Jane; Cooke-Bailey, Jessica N; Vithana, Eranga; Gharahkhani, Puya; Boutin, Thibaud; Ramdas, Wishal D; Zeller, Tanja; Luben, Robert N; Yonova-Doing, Ekaterina; Yazar, Seyhan; Cree, Angela J; Haines, Jonathan L; Koh, Jia Yu; Souzeau, Emmanuelle; Wilson, James F; Amin, Najaf; Muller, Christian; Venturini, Cristina; Kearns, Lisa S; Kang, Jae Hee; Tham, Yih Chung; Zhou, Tiger; van Leeuwen, Elisabeth M; NIckels, Stefan; Sanfilippo, Paul Gerard; Liao, Jiemin; van der Linde, Herma; Zhao, Wanting; van Koolwijk, Leonieke M E; Zheng, Li; Rivadeneira, Fernando; Baskaran, Mani; van der Lee, Sven J; Perera, Shamira; de Jong, Paulus T V M; Oostra, Ben A; Uitterlinden, Andre G; Fan, Qiao; Hofman, Albert; Tai, E-Shyong; Vingerling, Johannes R; Sim, Xueling; Wolfs, Roger C W; Teo, Yik Ying; Lemij, Hans G; Khor, Chiea Chuen; Willemsen, Rob; Lackner, Karl J; Aung, Tin; Jansonius, Nomdo M; Montgomery, Grant W; Wild, Philipp S; Young, Terri L; Burdon, Kathryn Penelope; Hysi, Pirro G; Pasquale, Louis R; Wong, Tien Yin; Klaver, Caroline C W; Hewitt, Alex W; Jonas, Jost B; Mitchell, Paul; Lotery, Andrew J; Foster, Paul J; Vitart, Veronique; Pfeiffer, Norbert; Craig, Jamie E; Mackey, David A; Hammond, Christopher J; Wiggs, Janey L; Cheng, Ching-Yu; van Duijin, Cornelia M; MacGregor, Stuart; Viswanathan, Ananth C (Oxford University Press, 2017-01)
      Primary open-angle glaucoma (POAG), the most common optic neuropathy, is a heritable disease. Siblings of POAG cases have a ten-fold increase risk of developing the disease. Intraocular pressure (IOP) and optic nerve head ...