Discovery and validation of molecular biomarkers for colorectal adenomas and cancer with application to blood testing
View/ Open
Date
2012-01-19Author
LaPointe, Lawrence C
Pedersen, Susanne K
Dunne, Robert
Brown, Glenn S
Pimlott, Letitia
Gaur, Snigdha
McEvoy, Aidan
Thomas, Melissa
Wattchow, David Anthony
Molloy, Peter L
Young, Graeme Paul
Metadata
Show full item recordAbstract
Results: Genome-wide analysis uncovered reproducible gene expression signatures for both adenomas and cancers
compared to controls. 386/489 (79%) of the adenoma and 439/529 (83%) of the adenocarcinoma biomarkers were validated
in independent tissues. We also identified genes differentially expressed in adenomas compared to cancer. KIAA1199 was
selected for further analysis based on consistent up-regulation in neoplasia, previous studies and its interest as an
uncharacterized gene. Plasma KIAA1199 RNA levels were significantly higher in patients with either cancer or adenoma (31/
40) compared to neoplasia-free controls (6/20).