Fish oil administration in older adults with cardiovascular disease or cardiovascular risk factors: is there potential for adverse events? A systematic review of the literature.
Villani, Anthony M
Cleland, Leslie G
James, Michael J
Fraser, Robert J L
Miller, Michelle Deanne
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Fish oil supplementation has become increasingly popular, often targeted for its role in the prevention or management of cardiovascular disease (CVD). However, the potential for severe adverse events (SAE) associated with omega-3 (n − 3) supplementation are not well documented, particularly in older adults with diagnosed CVD or CVD risk factors. The most commonly raised concern is their potential to increase the risk of serious bleeds  and . Consequently we conducted a systematic review of randomized controlled trials (RCTs) to identify the potential for AEs associated with n − 3 supplementation in older adults aged ≥ 60 years with diagnosed CVD or CVD risk factors.
This article appeared in a journal published by Elsevier Ltd. Under Elsevier's copyright, mandated authors are not permitted to make work available in an institutional repository.