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dc.contributor.authorDaud, Wan Najmi Ajmi Wan
dc.contributor.authorThompson, Sarah K
dc.contributor.authorJamieson, Glyn G
dc.contributor.authorDevitt, Peter G
dc.contributor.authorMartin, Ian J G
dc.contributor.authorWatson, David Ian
dc.date.accessioned2014-02-18T02:27:48Z
dc.date.available2014-02-18T02:27:48Z
dc.date.issued2013-11-28
dc.identifier.citationDaud, W. N. W., Thompson, S. K., Jamieson, G. G., Devitt, P. G., Martin, I. J. G. and Watson, D. I. (2015), Randomized controlled trial of laparoscopic anterior 180° partial versus posterior 270° partial fundoplication. ANZ Journal of Surgery, 85: 668–672. doi: 10.1111/ans.12476en
dc.identifier.urihttp://hdl.handle.net/2328/27280
dc.descriptionArticle first published online: 28 NOV 2013. This item is under embargo for a period of 12 months from the date of publication, in accordance with the publisher's policy.en
dc.description.abstractBACKGROUND: Previous trials show good outcomes following anterior and posterior partial versus Nissen fundoplication for gastro-oesophageal reflux. However, it is unclear which partial fundoplication performs best. This study compared anterior 180° versus posterior 270° fundoplication. METHODS: At three hospitals, patients were randomized to anterior 180° versus posterior 270° partial fundoplication, and clinical outcomes were determined using a structured questionnaire at 3, 6 and 12 months. Heartburn, dysphagia and satisfaction were assessed using 0-10 analoue scales, and adverse outcomes and side effects were determined. Endoscopy, manometry and pH monitoring were performed 6 months after surgery. RESULTS: Forty-seven patients were randomized to anterior (n = 23) versus posterior (n = 24) fundoplication. Clinical outcomes for 93-98% of patients were available at each follow-up point. At 12 months, the mean heartburn score was higher following anterior fundoplication (2.7 versus 0.8, P = 0.045), although differences were not significant at earlier follow-up. Conversely, following posterior fundoplication, patients were less able to belch at 3 (56% versus 16%, P = 0.013) and 6 months (43% versus 9%, P = 0.017). No significant differences were demonstrated for dysphagia. Both groups had high rates of satisfaction with the outcome - 85% versus 86% satisfied at 12 months follow-up. CONCLUSION: Both partial fundoplications are effective treatments for gastro-oesophageal reflux. Posterior partial fundoplication is associated with less reflux symptoms offset by more side effects.en
dc.description.sponsorshipAustralian National Health & Medical Research Council.en
dc.language.isoen
dc.publisherWileyen
dc.relationhttp://purl.org/au-research/grants/nhmrc/375111en
dc.relationhttp://purl.org/au-research/grants/nhmrc/1022722en
dc.rights© 2013 Royal Australasian College of Surgeons.en
dc.subjectRandomized controlled trialen
dc.subjectFundoplicationen
dc.subjectLaparoscopyen
dc.subjectGastro-oesophageal reflux diseaseen
dc.titleRandomized controlled trial of laparoscopic anterior 180° partial versus posterior 270° partial fundoplication.en
dc.typeArticleen
dc.relation.grantnumberNHMRC/375111en
dc.relation.grantnumberNHMRC/1022722en
dc.identifier.doihttps://doi.org/10.1111/ans.12476en
local.contributor.authorOrcidLookupWatson, David Ian: https://orcid.org/0000-0002-7683-2693en_US


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