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dc.contributor.authorLoots, Clara M
dc.contributor.authorSmits, Marije
dc.contributor.authorOmari, Taher
dc.contributor.authorBennink, Roelof J
dc.contributor.authorBenninga, Marc Alexander
dc.contributor.authorvan Wijk, Michiel P
dc.date.accessioned2014-03-04T03:22:06Z
dc.date.available2014-03-04T03:22:06Z
dc.date.issued2013-03
dc.identifier.citationLoots C, Smits M, Omari T, Bennink R, Benninga M, Van Wijk M. Effect of lateral positioning on gastroesophageal reflux (GER) and underlying mechanisms in GER disease (GERD) patients and healthy controls. Neurogastroenterol Motil. (2013) 25 3 222-9en
dc.identifier.issn1350-1925
dc.identifier.urihttp://hdl.handle.net/2328/27494
dc.descriptionAuthor version reproduced here in accordance with publisher policy.en
dc.description.abstractBackground Posture has been shown to influence the number of transient lower esophageal sphincter relaxation (TLESRs) and GER, however the physiology explaining the influence of right lateral position (RLP) and left lateral position (LLP) is unclear. The aim of this study was to determine the influence of RLP and LLP on TLESRs and GERD after a meal in GER disease (GERD) patients and healthy controls (HC) while monitoring gastric distension and emptying. Methods Ten GERD patients and ten HC were studied for 90min (30min test meal infusion, 30min post-prandial in either RLP or LLP (randomly assigned) and 30 min in alternate position). The study was repeated on a separate day in reverse position order. TLESRs, GER and gastric empting rate were recorded using manometry, multichannel intraluminal impedance and 13C-octanoate breath tests. Gastric distension was visualized by five serial gastric volume scintigraphy scans during the first 30 min. Key results GERD patients had increased numbers of TLESRs in RLP compared to LLP in the first postprandial hour (5(4-14) and 4.5(2-6) respectively, p=0.046) whereas the number of TLESRs was not different in RLP and LLP (4(2-4) and 4(3-6) respectively, p=0.7) in HC. Numbers of GER increased similar to TLESRs in GERD patients. In GERD patients gastric emptying reached peak 13CO2 excretion faster and proximal gastric distension was more pronounced. Conclusion & Inferences In GERD patients, TLESRs, GER, distension of proximal stomach and gastric emptying are increased in RLP compared to LLP. This effect is not seen in HC.en
dc.language.isoen
dc.publisherWileyen
dc.relationhttp://purl.org/au-research/grants/nhmrc/565067en
dc.rights© 2012 Blackwell Publishing Ltden
dc.subjectGastroesophageal refluxen
dc.subjectManometryen
dc.titleEffect of lateral positioning on gastroesophageal reflux (GER) and underlying mechanisms in GER disease (GERD) patients and healthy controlsen
dc.typeArticleen
dc.relation.grantnumberNHMRC/565067en
dc.identifier.doihttps://doi.org/10.1111/nmo.12042en
dc.rights.holderBlackwellen
local.contributor.authorOrcidLookupOmari, Taher: https://orcid.org/0000-0001-5108-7378en_US


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