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dc.contributor.authorMohammed, Mazher
dc.contributor.authorKulasekara, Keerthi K
dc.contributor.authorDe Menezes, Rodrigo Cunha
dc.contributor.authorOotsuka, Youichirou
dc.contributor.authorBlessing, William Walter
dc.date.accessioned2014-03-27T00:27:00Z
dc.date.available2014-03-27T00:27:00Z
dc.date.issued2013
dc.identifier.citationMohammed M, Kulasekara K, De Menezes RC, Ootsuka Y, Blessing WW. Inactivation of neuronal function in the amygdaloid region reduces tail artery blood flow alerting responses in conscious rats. Neuroscience. 2013 Jan 3;228:13-22.en
dc.identifier.issn0306-4522
dc.identifier.urihttp://hdl.handle.net/2328/27523
dc.descriptionCopyright © 2012 IBRO. Published by Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.description.abstractFew studies have investigated whether neuronal function in the amygdaloid complex is necessary for the occurrence of the cardiovascular response to natural (unconditioned) environmental threats. In the present investigation in conscious unrestrained Sprague–Dawley rats we inactivated neuronal function in the amygdaloid complex acutely (bilateral muscimol injections) or chronically (unilateral or bilateral ibotenic acid injections) and measured the effect on sudden falls in tail artery blood flow elicited by non-noxious salient stimuli (sympathetic cutaneous vasomotor alerting responses, SCVARs). After acute bilateral injection of vehicle (200 nl Ringer’s solution) the SCVAR index was 81 ± 2%, indicating that tail blood flow was reduced by 81% in response to the salient stimuli. After acute bilateral injection of muscimol (1 nmol in 200 nl of Ringer’s solution) into the amygdaloid complex the SCVAR index was 49 ± 5%, indicating that tail blood flow was reduced by 49% in response to the salient stimuli (p < 0.01 versus vehicle, n = 7 rats for vehicle and 6 for muscimol). One week after unilateral ibotenic acid lesions, the SCVAR index was 68 ± 3%, significantly less than 90 ± 1%, the corresponding value after unilateral injection of vehicle (p < 0.01, n = 6 rats in each group). After bilateral ibotenic acid lesions the SCVAR index was 52 ± 4%, significantly less than 93 ± 1%, the corresponding value after bilateral injection of vehicle (p < 0.001, n = 6 rats in each group). Ibotenic acid caused extensive neuronal destruction of the whole amygdaloid complex, as well as lateral temporal lobe structures including the piriform cortex. Our results demonstrate that the amygdaloid complex plays an important role in mediating the tail artery vasoconstriction that occurs in rats in response to the animal’s perception of a salient stimulus, redirecting blood to areas of the body with more immediate metabolic requirements.
dc.language.isoenen_US
dc.publisherElsevieren
dc.relationhttp://purl.org/au-research/grants/nhmrc/426713en
dc.rightsCopyright © 2012 IBRO. Published by Elsevier Ltd. All rights reserved.en_US
dc.subjectBlood flow
dc.subjectIntraventricular infusions
dc.titleInactivation of neuronal function in the amygdaloid region reduces tail artery blood flow alerting responses in conscious ratsen_US
dc.typeArticleen
dc.relation.grantnumberNHMRC/426713en_US
dc.identifier.doihttps://doi.org/10.1016/j.neuroscience.2012.10.008en
dc.rights.holderIBROen_US
dc.rights.licenseCC-BY-NC-ND


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