Now showing items 41-60 of 176

    • Corneal transplantation for keratoconus: a registry study. 

      Kelly, Thu-Lan; Williams, Keryn Anne; Coster, Douglas John (American Medical Association, 2011-06)
      To determine factors influencing long-term graft survival and visual acuity in 4834 eyes of 4060 patients receiving their first penetrating corneal graft for keratoconus, a large cohort study was performed from a national ...
    • Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases 

      Iglesias, Adriana; Mishra, Aniket; Vitart, Veronique; Bykhovskaya, Yelena; Hohn, Rene; Springelkamp, Henriet; Cuellar-Partida, Gabriel; Gharahkhani, Puya; Cooke Bailey, Jessica N; Willoughby, Colin E; Li, Xiaohui; Yazar, Seyhan; Nag, Abhishek; Khawaja, Anthony; Polasek, Ozren; Siscovick, David; Mitchell, Paul; Tham, Yih Chung; Haines, Jonathan L; Kearns, Lisa S; Hayward, Caroline; Shi, Yan; van Leeuwen, Elisabeth M; Taylor, Kent D; Blue Mountains Eye Study - GWAS group,; Bonnemaijer, Pieter; Rotter, Jerome I; Martin, Nicholas G; Zeller, Tanja; Mills, Richard Arthur; Souzeau, Emmanuelle; Staffieri, Sandra E; Jonas, Jost B; Schmidtmann, Irene; Boutin, Thibaud; Kang, Jae Hee; Lucas, Sionne E; Wong, Tien Yin; Beutel, Manfred E; Wilson, James F; Neighborhood Consortium; Uitterlinden, Andre G; Vithana, Eranga; Foster, Paul J; Hysi, Pirro G; Hewitt, Alex W; Khor, Chiea Chuen; Pasquale, Louis R; Montgomery, Grant W; Klaver, Caroline C W; Aung, Tin; Pfeiffer, Norbert; Mackey, David A; Hammond, Christopher J; Cheng, Ching-Yu; Craig, Jamie E; Rabinowitz, Yaron S; Wiggs, Janey L; van Duijn, Cornelia M; MacGregor, Stuart (Springer Nature, 2018-05-14)
      Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. ...
    • A cross-ethnicity investigation of genes previously implicated in primary angle closure glaucoma 

      Awadalla, Mona S; Burdon, Kathryn Penelope; Thapa, Suman S; Hewitt, Alex W; Craig, Jamie E (Emory Eye Centre, 2012)
      Purpose: To investigate the underlying genetic variation between candidate genes and primary angle closure glaucoma (PACG) in both Nepalese and Australian populations. Methods: A total of 213 patients with PACG (106 Nepalese ...
    • Crowd-sourced Ontology for Photoleukocoria: Identifying Common Internet Search Terms for a Potentially Important Pediatric Ophthalmic Sign 

      Staffieri, Sandra E; Kearns, Lisa S; Sanfilippo, Paul Gerard; Craig, Jamie E; Mackey, David A; Hewitt, Alex W (ARVO Journals, 2018-02-15)
      Purpose: Leukocoria is the most common presenting sign for pediatric eye disease including retinoblastoma and cataract, with worse outcomes if diagnosis is delayed. We investigated whether individuals could identify ...
    • Crowd-sourced Ontology for Photoleukocoria: Identifying Common Internet Search Terms for a Potentially Important Pediatric Ophthalmic Sign 

      Staffieri, Sandra E; Kearns, Lisa S; Sanfilippo, Paul Gerard; Craig, Jamie E; Mackey, David A; Hewitt, Alex W (ARVO Journals, 2018-02-15)
      Purpose: Leukocoria is the most common presenting sign for pediatric eye disease including retinoblastoma and cataract, with worse outcomes if diagnosis is delayed. We investigated whether individuals could identify ...
    • CYP1B1 copy number variation is not a major contributor to primary congenital glaucoma 

      Souzeau, Emmanuelle; Hayes, Melanie; Ruddle, Jonathan B; Elder, James E; Staffieri, Sandra E; Kearns, Lisa S; Mackey, David A; Zhou, Tiger; Ridge, Bronwyn; Burdon, Kathryn Penelope; Dubowsky, Andrew; Craig, Jamie E (Molecular Vision, 2015-02-11)
      Purpose: To evaluate the prevalence and the diagnostic utility of testing for CYP1B1 copy number variation (CNV) in primary congenital glaucoma (PCG) cases unexplained by CYP1B1 point mutations in The Australian and New ...
    • Deep anterior lamellar keratoplasty versus penetrating keratoplasty for treating keratoconus 

      Keane, Miriam Claire; Coster, Douglas John; Ziaei, M; Williams, Keryn Anne (John Wiley & Sons, Ltd., 2014)
      BACKGROUND: Keratoconus is an ectatic (weakening) disease of the cornea, which is the clear surface at the front of the eye. Approximately 10% to 15% of patients diagnosed with keratoconus require corneal transplantation. ...
    • Differential Gene Expression Profiling of Orbital Adipose Tissue in Thyroid Orbitopathy 

      Khong, Jwu Jin; Wang, Lynn Yuning; Smyth, Gordon K; McNab, Alan A; Hardy, Thomas G; Selva, Dinesh; Llamas, Bastien; Jung, Chol-Hee; Sharma, Shiwani; Burdon, Kathryn Penelope; Ebeling, Peter R; Craig, Jamie E (Association for Research in Vision and Ophthalmology (ARVO), 2015)
      PURPOSE. We aimed to determine differentially expressed genes relevant to orbital inflammation and orbital fat expansion in thyroid orbitopathy (TO) using microarray gene profiling in a case-control study. METHODS. Human ...
    • DNA methylation at the 9p21 glaucoma susceptibility locus is associated with normal-tension glaucoma 

      Burdon, Kathryn Penelope; Awadalla, Mona S; Mitchell, Paul; Wang, Jie Jin; White, Andrew J; Keane, Miriam Claire; Souzeau, Emmanuelle; Graham, Stuart L; Goldberg, Ivan; Healey, Paul R; Landers, John; Mills, Richard Arthur; Best, Stephen; Hewitt, Alex W; Sharma, Shiwani; Craig, Jamie E (Taylor & Francis Group, 2017-12-21)
      Purpose: Recent genome-wide association studies reported strong association of genetic variation at the CDKN2B/CDKN2B-AS1 locus on 9p21 with normal-tension glaucoma (NTG) in multiple populations. The mechanism by which ...
    • DNA methylation landscape of ocular tissue relative to matched peripheral blood 

      Hewitt, Alex W; Januar, Vania; Sexton-Oates, Alexandra; Joo, Jihoon E; Franchina, Maria; Wang, Jie Jin; Liang, Helena; Craig, Jamie E; Saffery, Richard (Nature Publishing Group, 2017-04-13)
      Epigenetic variation is implicated in a range of non-communicable diseases, including those of the eye. However, investigating the role of epigenetic variation in central tissues, such as eye or brain, remains problematic ...
    • Effectiveness of the community-based Low Vision Service Wales: a long-term outcome study 

      Ryan, Barbara; Khadka, Jyoti; Bunce, Catey; Court, Helen (BMJ Group, 2013-02-14)
      Aims To evaluate the long-term effectiveness of the community-based Low Vision Service Wales (LVSW). Methods A long-term observational study of the Government-funded, community-based, low-vision rehabilitation service ...
    • Epigenetic effects on eye diseases 

      Hewitt, Alex W; Wang, Jie Jin; Liang, Helena; Craig, Jamie E (Informa Plc, 2012-04)
      Epigenetics is the process by which patterns of gene expression are modified in a mitotically heritable manner. However, these epigenetic variations are not attributable to changes in the primary nucleotide sequence within ...
    • Establishing Levels of Indications for Cataract Surgery: Combining Clinical and Questionnaire Data into a Measure of Cataract Impact 

      McAlinden, Colm; Jonsson, M; Kugelberg, M; Lundstr, M; Khadka, Jyoti; Pesudovs, Konrad (Association for Research in Vision and Ophthalmology, Inc., 2012-03)
      Purpose.: To develop a model for establishing indications for cataract surgery that incorporates clinical and questionnaire data on a single linear scale using Rasch analysis. Methods.: In this prospective study, 293 ...
    • Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2015: the Global Burden of Disease Study 2015 

      Wang, Haidong; Wolock, Tim M; Carter, Austin; Nguyen, Grant; Kyu, Hmwe Hmwe; Gakidou, Emmanuela; Hay, Simon I; Mills, Edward J; Trickey, Adam; Msemburi, William; Coates, Michael M; Mooney, Meghan D; Fraser, Maya S; Sligar, Amber; Salomon, Joshua; Larson, Heidi J; Friedman, Joseph; Abajobir, Amanuel Alemu; Abate, Kalkidan Hassen; Abbas, Kaja M; El Razek, Mohamed Magdy; Abd-Allah, Foad; Abdulle, Abdishakur M; Abera, Semaw Ferede; Abubakar, Ibrahim; Pesudovs, Konrad; et. al. (Elsevier, 2016-01-19)
      Background Timely assessment of the burden of HIV/AIDS is essential for policy setting and programme evaluation. In this report from the Global Burden of Disease Study 2015 (GBD 2015), we provide national estimates of ...
    • Ethical Considerations for the Return of Incidental Findings in Ophthalmic Genomic Research 

      Souzeau, Emmanuelle; Burdon, Kathryn Penelope; Mackey, David A; Hewitt, Alex W; Savarirayan, Ravi; Otlowski, M; Craig, Jamie E (Association for Research in Vision and Ophthalmology (ARVO), 2016)
      Whole genome and whole exome sequencing technologies are being increasingly used in research. However, they have the potential to identify incidental findings (IF), findings not related to the indication of the test, raising ...
    • Expression of an anti-CD4 single-chain antibody fragment from the donor cornea can prolong corneal allograft survival in inbred rats 

      Appleby, Sarah Louise; Jessup, Claire Frances; Mortimer, Lauren A; Kirk, Kirsty; Brereton, Helen Mary; Coster, Douglas John; Tan, Chuan K; Williams, Keryn Anne (BMJ Group, 2012-11-21)
      To investigate whether expression of an anti-CD4 antibody fragment (scFv) by a lentivector-transduced donor cornea can prolong rat corneal allograft survival. Methods Inbred Fischer 344 rats received penetrating corneal ...
    • Gene therapy for corneal dystrophies and disease, where are we? 

      Williams, Keryn Anne; Klebe, Sonja (Lippincott Williams & Wilkins, 2012-07)
      We assess studies on vector systems for delivery of transgenes to the cornea that have been published over the last year, and summarise new work on the identification of specific transgenes for corneal diseases. Recent ...
    • Genetic analysis of the clusterin gene in pseudoexfoliation syndrome. 

      Sharma, Shiwani; Burdon, Kathryn Penelope; Craig, Jamie E; Hewitt, Alex W; Wang, Jie Jin; Mackey, David A; Mitchell, Paul; McMellon, Amy E (2008)
    • Genetic Association at the 9p21 Glaucoma Locus Contributes to Sex Bias in Normal-Tension Glaucoma 

      Ng, Soo Khai; Burdon, Kathryn Penelope; Fitzgerald, Jude T; Zhou, Tiger; Fogarty, Rhys Daniel; Souzeau, Emmanuelle; Landers, John; Mills, Richard Arthur; Casson, Robert J; Ridge, Bronwyn; Graham, Stuart L; Hewitt, Alex W; Mackey, David A; Healey, Paul R; Wang, Jie Jin; Mitchell, Paul; MacGregor, Stuart; Craig, Jamie E (Association for Research in Vision and Ophthalmology (ARVO), 2016)
    • Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci 

      Aung, Tin; Ozaki, Mineo; Lee, Mei Chin; Schlotzer-Schrehardt, Ursula; Thorleifsson, Gudmar; Mizoguchi, Takanori; Igo Jr, Robert P; Haripriya, Aravind; Williams, Susan E; Astakhov, Yury S; Orr, Andrew C; Burdon, Kathryn Penelope; Nakano, Satoko; Mori, Kazuhiko; Abu-Amero, Khaled; Hauser, Michael; Li, Zheng (Genome Institute Of Singapore); Prakadeeswari, Gopalakrishnan; Cooke-Bailey, Jessica N; Cherecheanu, Alina Popa; Kang, Jae Hee; Nelson, Sarah; Hayashi, Ken; Manabe, Shin-Ichi; Kazama, Shigeyasu; Zarnowski, Tomasz; Inoue, Kenji; Irkec, Murat; Coca-Prados, Miguel; Sugiyama, Kazuhisa; Jarvela, Irma; Schlottmann, Patricio; Lerner, S Fabian; Lamari, Hasnaa; Nilgun, Yildirim; Bikbov, Mukharram; Park, Ki Ho; Cha, Soon Cheol; Yamashiro, Kenji; Zenteno, Juan C; Jonas, Jost B; Kumar, Rajesh S; Perera, Shamira A; Chan, Anita S Y; Kobakhidze, Nino; George, Ronnie; Vijaya, Lingam; Do, Tan; Edward, Deepak P; Marcos, Lourdes De Juan; Pakravan, Mohammad; Moghimi, Sasan; Ideta, Ryuichi; Bach-Holm, Daniella; Kappelgaard, Per; Wirostko, Barbara; Thomas, Samuel; Gaston, Daniel; Bedard, Karen; Greer, Wenda L; Yang, Zhenglin; Chen, Xueyi; Huang, Lulin; Sang, Jinghong; Jia, Hongyan; Jia, Liyun; Qiao, Chunyan; Zhang, Hui; Liu, Xuyang; Zhao, Bowen; Wang, Ya Xing; Xu, Liang; Leruez, Stephanie; Reynier, Pascal; Chichua, George; Tabagari, Sergo; Uebe, Steffen; Zenkel, Matthias; Berner, Daniel; Mossbock, Georg; Weisschuh, Nicole; Hoja, Ursula; Welge-Luessen, Ulrich-Christoph; Mardin, Christian; Founti, Panayiota; Chatzikyriakidou, Anthi; Pappas, Theofanis; Anastasopoulos, Eleftherios; Lambropoulos, Alexandros; Ghosh, Arkasubhra; Shetty, Rohit; Porporato, Natalia; Saravanan, Vijayan; Venkatesh, Rengaraj; Shivkumar, Chandrashekaran; Kalpana, Narendran; Sarangapani, Sripriya; Kanavi, Mozhgan R; Beni, Afsaneh Naderi; Yazdani, Shahin; Lashay, Alireza; Naderifar, Homa; Khatibi, Nassim; Fea, Antonio; Lavia, Carlo; Dallorto, Laura; Rolle, Teresa; Frezzotti, Paolo; Paoli, Daniela; Salvi, Erika; Manunta, Paolo; Mori, Yosai; Miyata, Kazunori; Higashide, Tomomi; Chihara, Etsuo; Ishiko, Satoshi; Yoshida, Akitoshi; Yanagi, Masahide; Kiuchi, Yoshiaki; Ohashi, Tsutomu; Sakurai, Toshiya; Sugimoto, Takako; Chuman, Hideki; Aihara, Makoto; Inatani, Masaru; Miyake, Masahiro; Gotoh, Norimoto; Matsuda, Fumihiko; Yoshimura, Nagahisa; Ikeda, Yoko; Ueno, Morio; Sotozono, Chie; Jeoung, Jin Wook; Sagong, Min; Park, Kyu Hyung; Ahn, Jeeyun; Cruz-Aguilar, Marisa; Ezzouhairi, Sidi M; Rafei, Abderrahman; Chong, Yaan Fun; Ng, Xiao Yu; Goh, Shuang Ru; Chen, Yueming; Yong, Victor H K; Khan, Muhammad Imran; Olawoye, Olusola O; Ashaye, Adeyinka O; Ugbede, Idakwo; Onakoya, Adeola; Kizor-Akaraiwe, Nkiru; Teekhasaenee, Chaiwat; Suwan, Yanin; Supakontanasan, Wasu; Okeke, Suhanya; Uche, Nkechi J; Asimadu, Ifeoma; Ayub, Humaira; Akhtar, Farah; Kosior-Jarecka, Ewa; Lukasik, Urszula; Lischinsky, Ignacio; Castro, Vania; Grossmann, Rodolfo Perez; Megevand, Gordana Sunaric; Roy, Sylvain; Dervan, Edward; Silke, Eoin; Rao, Aparna; Sahay, Priti; Fornero, Pablo; Cuello, Osvaldo; Sivori, Delia; Zompa, Tamara; Mills, Richard Arthur; Souzeau, Emmanuelle; Mitchell, Paul; Wang, Jie Jin; Hewitt, Alex W; Coote, Michael; Crowston, Jonathan G; Astakhov, Sergei Y; Akopov, Eugeny L; Emelyanov, Anton; Vysochinskaya, Vera; Kazakbaeva, Gyulli; Fayzrakhmanov, Rinat; Al-Obeidan, Saleh A; Owaidhah, Ohoud; Aljasim, Leyla Ali; Chowbay, Balram; Foo, Jia Nee; Soh, Raphael Q; Sim, Kar Seng; Xie, Zhicheng; Cheong, Augustine W O; Mok, Shi Qi; Soo, Hui Meng; Chen, Xiao Y; Peh, Su Qin; Heng, Khai Koon; Husain, Rahat; Ho, Su-Ling; Hillmer, Axel M; Cheng, Ching-Yu; Escudero-Dominguez, F A; Gonzalez-Sarmiento, Rogelio; Martinon-Torres, Frederico; Salas, Antonio; Pathanapitoon, Kessara; Hansapinyo, Linda; Wanichwecharugruang, Boonsong; Kitnarong, Naris; Sakuntabhai, Anavaj; Nguyn, Hip X; Nguyn, Giang T T; Nguyn, Trinh V; Zenz, Werner; Binder, Alexander; Klobassa, Daniela S; Hibberd, Martin L; Davila, Sonia; Herms, Stefan; Nothen, Markus M; Moebus, Susanne; Rautenbach, Robyn M; Ziskind, Ari; Carmichael, Trevor R; Ramsay, Michele; Alvarez, Lydia; Garcia, Montserrat; Gonzalez-Iglesias, Hector; Rodriguez-Calvo, Pedro P; Fernandez-Vega Cueto, Luis; Oguz, Cilingir; Tamcelik, Nevbahar; Atalay, Eray; Batu, Bilge; Aktas, Dilek; Kasim, Burcu; Wilson, M Roy; Coleman, Anne L; Liu, Yutao; Challa, Pratap; Herndon, Leon; Kuchtey, Rachel W; Kuchtey, John (Nature Publishing Group, 2017-05-29)
      Exfoliation syndrome (XFS) is the most common known risk factor for secondary glaucoma and a major cause of blindness worldwide. Variants in two genes, LOXL1 and CACNA1A, have previously been associated with XFS. To further ...