Now showing items 141-160 of 174

    • Prevalence of FOXC1 Variants in Individuals With a Suspected Diagnosis of Primary Congenital Glaucoma 

      Siggs, Owen M; Souzeau, Emmanuelle; Pasutto, Francesca; Dubowsky, Andrew; Smith, James E H; Taranath, Deepa A; Pater, John Brian; Rait, Julian L; Narita, Andrew; Mauri, Lucia; Del Longo, Alessandra; Reis, Andre; Chappell, Angela J; Kearns, Lisa A; Staffieri, Sandra E; Elder, James E; Ruddle, Jonathan B; Hewitt, Alex W; Burdon, Kathryn Penelope; Mackey, David A; Craig, Jamie E (American Medical Association, 2019-01-17)
      Importance Both primary and secondary forms of childhood glaucoma have many distinct causative mechanisms, and in many cases a cause is not immediately clear. The broad phenotypic spectrum of secondary glaucoma, particularly ...
    • The prevalence of glaucoma in indigenous Australians within Central Australia: the Central Australian Ocular Health Study 

      Landers, John; Henderson, Timothy R; Craig, Jamie E (BMJ Group, 2011-04-22)
      Aims To determine the prevalence of glaucoma within the indigenous Australian population living in central Australia. Methods 1884 individuals aged ≥20 years, living in one of 30 remote communities within the statistical ...
    • Prognostic Indicators and Outcome Measures for Surgical Removal of Symptomatic Nonadvanced Cataract 

      Charalampidou, S; Loughman, J; Nolan, J; Stack, J; Cassidy, L T; Pesudovs, Konrad (American Medical Association, 2011-09)
      Objectives To report changes in perceived visual functioning after surgery for symptomatic cataract with preoperative corrected distance visual acuity [CDVA] of 0.4 logMAR or better (Snellen equivalent, 20/50) and to ...
    • Promoter polymorphism at the tumour necrosis factor/lymphotoxin-alpha locus is associated with type of diabetes but not with susceptibility to sight-threatening diabetic retinopathy 

      Kaidonis, Georgia; Craig, Jamie E; Gillies, Mark; Abhary, Sotoodeh; Essex, Rohan; Chang, J H; Pal, Bishwanath; Pefkianaki, Maria; Daniell, Mark; Lake, Stewart; Petrovsky, Nikolai; Burdon, Kathryn Penelope (SAGE Publications, 2016-01-28)
      AIM: To investigate, in a large cohort of 2494 individuals with diabetes mellitus, whether functional single nucleotide polymorphisms in the promoter region of tumour necrosis factor (TNF) and lymphotoxin-alpha (LTA) ...
    • A Proposed Minimum Standard Set of Outcome Measures for Cataract Surgery 

      Mahmud, Imran; Kelley, Thomas; Stowell, Caleb; Haripriya, Aravind; Boman, Anders; Kossler, Ingrid; Morlet, Nigel; Pershing, Suzann; Pesudovs, Konrad; Goh, Pik Pin; Sparrow, John M; Lundstrom, Mats (American Medical Association, 2015-08-20)
      Importance Aligning outcome measures for cataract surgery, one of the most frequently performed procedures globally, may facilitate international comparisons that can drive improvements in the outcomes most meaningful to ...
    • Psychometric Properties of the NEI-RQL-42 Questionnaire in Keratoconus 

      McAlinden, Colm; Khadka, Jyoti; Santos Paranhos, Juliane de Freitas; Schor, Paulo; Pesudovs, Konrad (Association for Research in Vision and Ophthalmology, Inc., 2012-10)
      Purpose.: To assess the psychometric properties of the National Eye Institute Refractive Error Quality of Life (NEI-RQL-42) questionnaire in keratoconus and compare these findings to patients with refractive error correction ...
    • Rare variants in optic disc area gene CARD10 enriched in primary open-angle glaucoma. 

      Zhou, Tiger; Souzeau, Emmanuelle; Sharma, Shiwani; Siggs, Owen M; Goldberg, Ivan; Healey, Paul R; Graham, Stuart L; Hewitt, Alex W; Mackey, David A; Casson, Robert J; Landers, John; Mills, Richard Arthur; Ellis, Jonathan; Leo, Paul; Brown, Matthew A; MacGregor, Stuart; Burdon, Kathryn Penelope; Craig, Jamie E (Wiley, 2016-10-03)
    • Rare, potentially pathogenic variants in 21 keratoconus candidate genes are not enriched in cases in a large Australian cohort of European descent 

      Lucas, Sionne E; Zhou, Tiger; Blackburn, Nicholas B; Mills, Richard Arthur; Ellis, Jonathan; Leo, Paul; Souzeau, Emmanuelle; Ridge, Bronwyn; Charlesworth, Jac C; Lindsay, Richard; Craig, Jamie E; Burdon, Kathryn Penelope (Public LIbrary of Science, 2018-06-20)
      Many genes have been suggested as candidate genes for keratoconus based on their function, their proximity to associated polymorphisms or due to the identification of putative causative variants within the gene. However, ...
    • Rare, Potentially Pathogenic Variants in ZNF469 Are Not Enriched in Keratoconus in a Large Australian Cohort of European Descent 

      Lucas, Sionne E; Zhou, Tiger; Blackburn, Nicholas B; Mills, Richard Arthur; Ellis, Jonathan; Leo, Paul; Souzeau, Emmanuelle; Ridge, Bronwyn; Charlesworth, Jac C; Brown, Matthew A; Lindsay, Richard; Craig, Jamie E; Burdon, Kathryn Penelope (Investigative Ophthalmology and Visual Science, 2017-12)
      Purpose: The Zinc Finger Protein 469 (ZNF469) gene has been proposed as a candidate gene for keratoconus due to the association of an upstream polymorphism (rs9938149) with the disease in two independent studies, and the ...
    • Recurrent atypical fibroxanthoma of the limbus 

      Ullrich, Katja; Wells, Jane; Brennan, Catriona; Craig, Jamie E (BMJ Publishing Group, 2013-03)
      We report an unusual presentation of recurrent atypical fibroxanthoma of the limbus. Clinical and histological appearance, as well as management are discussed and the current literature is reviewed.
    • Recurrent mutation in the crystallin alpha A gene associated with inherited paediatric cataract 

      Javadiyan, Shahrbanou; Craig, Jamie E; Souzeau, Emmanuelle; Sharma, Shiwani; Lower, Karen Marie; Pater, John Brian; Casey, Theresa; Hodson, T; Burdon, Kathryn Penelope (BioMed Central, 2016)
      Background: Cataract is a major cause of childhood blindness worldwide. The purpose of this study was to determine the genetic cause of paediatric cataract in a South Australian family with a bilateral lamellar paediatric ...
    • Reengineering the Glaucoma Quality of Life-15 Questionnaire with Rasch Analysis 

      Khadka, Jyoti; Pesudovs, Konrad; McAlinden, Colm; Vogel, M; Kernt, M; Hirneiss, C (Association for Research in Vision and Ophthalmology, Inc., 2011-08)
      Purpose.: To investigate, using Rasch analysis, whether the 15-item Glaucoma Quality of Life-15 (GQL-15) forms a valid scale and to optimize its psychometric properties. Methods.: One hundred eighteen glaucoma patients ...
    • Rejection and acceptance of corneal allografts 

      Klebe, Sonja; Coster, Douglas John; Williams, Keryn Anne (Lippincott, Williams & Wilkins, 2009)
      PURPOSE OF REVIEW: Corneal transplantation is successful in the short-term, but the long-term prognosis has not improved over the past 20 years. Here, we review recent findings that may contribute to improved corneal ...
    • The related transcriptional enhancer factor-1 isoform, TEAD4 216, can repress vascular endothelial growth factor expression in mammalian cells 

      Appukuttan, Binoy; McFarland, Trevor J; Stempel, Andrew; Kassem, Jean B; Hartzell, Matthew; Zhang, Yi; Bond, Derek; West, Kelsey; Wilson, Reid; Stout, Andrew; Pan, Yuzhen; Ilias, Hoda; Robertson, Kathryn; Klein, Michael L; Wilson, David; Smith, Justine R; Stout, J Timothy (Public Library of Science, 2012-06-22)
      Increased cellular production of vascular endothelial growth factor (VEGF) is responsible for the development and progression of multiple cancers and other neovascular conditions, and therapies targeting post-translational ...
    • The reliability of single-field fundus photography in screening for diabetic retinopathy: the Central Australian Ocular Health Study 

      Ku, Janice J-Y; Landers, John; Henderson, Timothy R; Craig, Jamie E (MJA Group Australia, 2012-10-26)
      Objective: To assess the accuracy of grading diabetic retinopathy (DR) using single-field digital fundus photography compared with clinical grading from a dilated slit-lamp fundus examination in Indigenous Australians ...
    • Repeat penetrating corneal transplantation in patients with keratoconus 

      Kelly, Thu-Lan; Coster, Douglas John; Williams, Keryn Anne (Elsevier, 2011-04-03)
      To determine factors influencing penetrating corneal graft survival in patients receiving repeat grafts in the same eye after a failed first graft for keratoconus, a large cohort study was conducted from a national register ...
    • Repeatability of corneal first-surface wavefront aberrations measured with Pentacam corneal topography [Post print] 

      Shankar, Hema; Taranath, Deepa A; Santhirathelagan, Chandramalar T; Pesudovs, Konrad (Elsevier, 2008-05)
      PURPOSE: To assess the repeatability of corneal wavefront aberrations derived from Pentacam (Oculus) corneal topography. SETTING: Flinders Eye Centre, Flinders Medical Centre, Bedford Park, South Australia, Australia. ...
    • The Responsibility to Recontact Research Participants after Reinterpretation of Genetic and Genomic Research Results 

      Bombard, Yvonne; Brothers, Kyle B; Fitzgerald-Butt, Sara; Garrison, Nanibaa' A; Jamal, Leila; James, Cynthia A; Jarvik, Gail P; McCormick, Jennifer B; Nelson, Tanya N; Ormond, Kelly E; Rehm, Heidi L; Richer, Julie; Souzeau, Emmanuelle; Vassy, Jason L; Wagner, Jennifer K; Levy, Howard P (Elsevier, 2019-04-04)
      The evidence base supporting genetic and genomic sequence-variant interpretations is continuously evolving. An inherent consequence is that a variant’s clinical significance might be reinterpreted over time as new evidence ...
    • Review of the prevalence of diabetic retinopathy in Indigenous Australians 

      Kaidonis, Georgia; Mills, Richard Arthur; Landers, John; Lake, Stewart; Burdon, Kathryn Penelope; Craig, Jamie E (2014)
      The purpose of this review is to compare the prevalence of diabetic retinopathy (DR) between Indigenous and non-Indigenous Australians with Diabetes Mellitus (DM). Australian DR prevalence data from 6 Indigenous studies ...
    • Rituximab therapy for refractory orbital inflammation: results of a phase 1/2, dose-ranging, randomized clinical trial 

      Suhler, Eric B; Lim, Lyndell L; Beardsley, Robert M; Giles, Tracy R; Pasadhika, Sirichai; Lee, Shelly T; de Saint Sardos, Alexandre G; Butler, Nicholas J; Smith, Justine R; Rosenbaum, James T (American Medical Association, 2014-05)
      IMPORTANCE: Orbital inflammation is a potentially blinding and disfiguring disease process that is often treated with systemic corticosteroids and immunosuppression; better treatments are needed. OBJECTIVE: To ...