Now showing items 153-172 of 174

    • Rejection and acceptance of corneal allografts 

      Klebe, Sonja; Coster, Douglas John; Williams, Keryn Anne (Lippincott, Williams & Wilkins, 2009)
      PURPOSE OF REVIEW: Corneal transplantation is successful in the short-term, but the long-term prognosis has not improved over the past 20 years. Here, we review recent findings that may contribute to improved corneal ...
    • The related transcriptional enhancer factor-1 isoform, TEAD4 216, can repress vascular endothelial growth factor expression in mammalian cells 

      Appukuttan, Binoy; McFarland, Trevor J; Stempel, Andrew; Kassem, Jean B; Hartzell, Matthew; Zhang, Yi; Bond, Derek; West, Kelsey; Wilson, Reid; Stout, Andrew; Pan, Yuzhen; Ilias, Hoda; Robertson, Kathryn; Klein, Michael L; Wilson, David; Smith, Justine R; Stout, J Timothy (Public Library of Science, 2012-06-22)
      Increased cellular production of vascular endothelial growth factor (VEGF) is responsible for the development and progression of multiple cancers and other neovascular conditions, and therapies targeting post-translational ...
    • The reliability of single-field fundus photography in screening for diabetic retinopathy: the Central Australian Ocular Health Study 

      Ku, Janice J-Y; Landers, John; Henderson, Timothy R; Craig, Jamie E (MJA Group Australia, 2012-10-26)
      Objective: To assess the accuracy of grading diabetic retinopathy (DR) using single-field digital fundus photography compared with clinical grading from a dilated slit-lamp fundus examination in Indigenous Australians ...
    • Repeat penetrating corneal transplantation in patients with keratoconus 

      Kelly, Thu-Lan; Coster, Douglas John; Williams, Keryn Anne (Elsevier, 2011-04-03)
      To determine factors influencing penetrating corneal graft survival in patients receiving repeat grafts in the same eye after a failed first graft for keratoconus, a large cohort study was conducted from a national register ...
    • Repeatability of corneal first-surface wavefront aberrations measured with Pentacam corneal topography [Post print] 

      Shankar, Hema; Taranath, Deepa A; Santhirathelagan, Chandramalar T; Pesudovs, Konrad (Elsevier, 2008-05)
      PURPOSE: To assess the repeatability of corneal wavefront aberrations derived from Pentacam (Oculus) corneal topography. SETTING: Flinders Eye Centre, Flinders Medical Centre, Bedford Park, South Australia, Australia. ...
    • The Responsibility to Recontact Research Participants after Reinterpretation of Genetic and Genomic Research Results 

      Bombard, Yvonne; Brothers, Kyle B; Fitzgerald-Butt, Sara; Garrison, Nanibaa' A; Jamal, Leila; James, Cynthia A; Jarvik, Gail P; McCormick, Jennifer B; Nelson, Tanya N; Ormond, Kelly E; Rehm, Heidi L; Richer, Julie; Souzeau, Emmanuelle; Vassy, Jason L; Wagner, Jennifer K; Levy, Howard P (Elsevier, 2019-04-04)
      The evidence base supporting genetic and genomic sequence-variant interpretations is continuously evolving. An inherent consequence is that a variant’s clinical significance might be reinterpreted over time as new evidence ...
    • Review of the prevalence of diabetic retinopathy in Indigenous Australians 

      Kaidonis, Georgia; Mills, Richard Arthur; Landers, John; Lake, Stewart; Burdon, Kathryn Penelope; Craig, Jamie E (2014)
      The purpose of this review is to compare the prevalence of diabetic retinopathy (DR) between Indigenous and non-Indigenous Australians with Diabetes Mellitus (DM). Australian DR prevalence data from 6 Indigenous studies ...
    • Rituximab therapy for refractory orbital inflammation: results of a phase 1/2, dose-ranging, randomized clinical trial 

      Suhler, Eric B; Lim, Lyndell L; Beardsley, Robert M; Giles, Tracy R; Pasadhika, Sirichai; Lee, Shelly T; de Saint Sardos, Alexandre G; Butler, Nicholas J; Smith, Justine R; Rosenbaum, James T (American Medical Association, 2014-05)
      IMPORTANCE: Orbital inflammation is a potentially blinding and disfiguring disease process that is often treated with systemic corticosteroids and immunosuppression; better treatments are needed. OBJECTIVE: To ...
    • Screening of the COL8A2 gene in an Australian family with early-onset Fuchs’ endothelial corneal dystrophy 

      Kuot, Abraham; Mills, Richard Arthur; Craig, Jamie E; Sharma, Shiwani; Burdon, Kathryn Penelope (John Wiley & Sons, Ltd, 2014-03)
    • Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes 

      Kuot, Abraham; Javadiyan, Shahrbanou; Abhary, Sotoodeh; Burdon, Kathryn Penelope; Whiting, Malcolm John; Kasmeridis, Nicholas; Petrovsky, Nikolai; Craig, Jamie E (2010)
      Asymmetric dimethylarginine (ADMA), present in human serum, is an endogenous inhibitor of nitric oxide synthase and contributes to vascular disease. Dimethylarginine dimethylaminohydrolase (DDAH) is an ADMA degrading enzyme ...
    • A simple corneal perfusion chamber for drug penetration and toxicity studies 

      Thiel, Michael A; Morlet, N; Schulz, D; Edelhauser, HF; Dart, JK; Coster, Douglas John; Williams, Keryn Anne (BMJ Publishing Group - http://bjo.bmjjournals.com/, 2001-04)
      AIMS: Corneal perfusion chambers are important tools in the development and assessment of ophthalmic drugs. The aim of this study was to design and test a modified perfusion chamber suitable for topical application of drugs ...
    • Species Cross-Reactivity of Antibodies Used to Treat Ophthalmic Conditions 

      Irani, Yazad; Scotney, Pierre; Nash, Andrew; Williams, Keryn Anne (Association for Research in Vision and Ophthalmology, 2016)
      PURPOSE: The species cross-reactivity of the monoclonal antibodies infliximab, bevacizumab, and an anti-VEGF-B antibody, 2H10, in humans and rodents was determined. METHODS: The binding of infliximab to human, mouse, and ...
    • Subjective Quality of Vision Before and After Cataract Surgery 

      Skiadaresi, S; McAlinden, Colm; Pesudovs, Konrad; Polizzi, S; Khadka, Jyoti; Ravalico, G (American Medical Association, 2012-11)
      Objective To investigate the effect of cataract surgery on subjective quality of vision. Methods The Quality of Vision (QoV) questionnaire (Italian translation) was completed before and 3 months after cataract surgery in ...
    • Subscale Assessment of the NEI-RQL-42 Questionnaire with Rasch Analysis 

      McAlinden, Colm; Skiadaresi, E; Moore, J; Pesudovs, Konrad (Association for Research in Vision and Ophthalmology, Inc., 2011-07)
      Purpose.: To explore the psychometric properties of the 13 subscales of the NEI-RQL-42 questionnaire using Rasch analysis. Methods.: The NEI-RQL-42 is a refractive error-related quality of life (QoL) questionnaire with a ...
    • Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility 

      Chintalapudi, Sumana R; Maria, Doaa; Wang, Xiang Di; Cooke Bailey, Jessica N; Neighborhood Consortium; International Glaucoma Genetics consortium; Hysi, Pirro G; Wiggs, Janey L; Williams, Robert W; Jablonski, Monica M; Craig, Jamie E (Springer Nature, 2017-11-24)
      Glaucoma is a multi-factorial blinding disease in which genetic factors play an important role. Elevated intraocular pressure is a highly heritable risk factor for primary open angle glaucoma and currently the only target ...
    • Targeting Endothelial Adhesion Molecule Transcription for Treatment of Inflammatory Disease: A Proof-of-Concept Study 

      Ashander, Liam M; Appukuttan, Binoy; Ma, Yuefang; Gardner-Stephen, Dione Anne (Hindawi Publishing Corporation, 2016)
      Targeting the endothelial adhesion molecules that control leukocyte trafficking into a tissue has been explored as a biological therapy for inflammatory diseases. However, these molecules also participate in leukocyte ...
    • Teaching Communication Skills: An Australian Optometry Program’s New Course 

      Brandenburg, Rob; Pesudovs, Konrad (Association of Schools and Colleges of Optometry., 2014-09)
      After a review of the literature, the authors describe the experience of developing and teaching a new communication skills course at Flinders University in South Australia. A follow-up survey indicated that optometry ...
    • The telomere of human chromosome 1p contains at least two independent autosomal dominant congenital cataract genes. 

      McKay, James D; Patterson, B; Craig, Jamie E; Russell-Eggit, Isabelle M; Wirth, M Gabriela; Burdon, Kathryn Penelope; Hewitt, Alex W; Cohn, Amy C; Kerdraon, Y; Mackey, David A (BMJ Publishing Group - http://bjo.bmjjournals.com/, 2005-07)
      AIMS: Multiple genetic causes of congenital cataract have been identified, both as a component of syndromes and in families that present with isolated congenital cataract. Linkage analysis was used to map the genetic locus ...
    • Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets 

      Cooke-Bailey, Jessica N; Gharahkhani, Puya; Kang, Jae Hee; Butkiewicz, Mariusz; Sullivan, David; Weinreb, Robert Neal; Aschard, Hugues; Allingham, R Rand; Ashley-Koch, Allison; Lee, Richard K; Moroi, Sayoko E; Brilliant, Murray H; Wollstein, Gadi; Schuman, Joel; Fingert, John H; Budenz, Donald L; Realini, Tony; Gaasterland, Terry; Scott, William K; Singh, Kuldev; Sit, Arthur J; Igo Jr, Robert P; Song, Yeunjoo E; Hark, Lisa; Ritch, Robert; Rhee, Douglas J; Vollrath, Douglas; Zack, Donald; Medeiros, Felipe; Vajaranant, Thasarat S; Chasman, Daniel I; Christen, William G; Pericak-Vance, Margaret A; Liu, Yutao; Kraft, Peter; Richards, Julia E; Rosner, Bernard A; Hauser, Michael A; Craig, Jamie E; Burdon, Kathryn Penelope; Hewitt, Alex W; Mackey, David A; Haines, Jonathan L; MacGregor, Stuart; Wiggs, Janey L; Pasquale, Louis R; Australian and New Zealand Registry of Advanced Glaucoma (ANZRAG) Consortium (Investigative Ophthalmology and Visual Science, 2018-02)
      Purpose: Sex hormones may be associated with primary open-angle glaucoma (POAG), although the mechanisms are unclear. We previously observed that gene variants involved with estrogen metabolism were collectively associated ...
    • TGC repeat expansion in the TCF4 gene increases the risk of Fuchs' endothelial corneal dystrophy in Australian cases 

      Kuot, Abraham; Hewitt, Alex W; Snibson, Grant R; Souzeau, Emmanuelle; Mills, Richard Arthur; Craig, Jamie E; Burdon, Kathryn Penelope; Sharma, Shiwani (Public Library of Science, 2017-08-23)
      Fuchs’ endothelial corneal dystrophy (FECD) is a progressive, vision impairing disease. Common single nucleotide polymorphisms (SNPs) and a trinucleotide repeat polymorphism, thymine-guanine-cytosine (TGC), in the TCF4 ...