Now showing items 22-41 of 176

    • Causes of vision loss worldwide, 1990–2010: a systematic analysis 

      Bourne, Rupert R A; Stevens, Gretchen A; White, Richard A; Smith, Jennifer L; Flaxman, Seth R; Price, Holly; Jonas, Jost B; Keeffe, Jill E; Leasher, Janet; Naidoo, Kovin (Elsevier, 2013-12)
      Background Data on causes of vision impairment and blindness are important for development of public health policies, but comprehensive analysis of change in prevalence over time is lacking. Methods We did a systematic ...
    • CD44 isoforms in human retinal and choroidal endothelial cells 

      Chipps, Timothy J; Appukuttan, Binoy; Pan, Yuzhen; Smith, Justine R (Springer Verlag, 2013)
    • Characterization of serous retinal detachments in uveitis patients with optical coherence tomography 

      Simmons-Rear, Annamieka; Yeh, Steven; Chan-Kai, Brian T; Lauer, Andreas K; Flaxel, Christina J; Smith, Justine R; Rosenbaum, James T; Suhler, Eric B (Springer-Verlag, 2012-06-02)
      To determine the prevalence of serous retinal detachments (SRD) using optical coherence tomography (OCT) in a large database of patients with uveitis from a tertiary referral setting, to describe clinical features of ...
    • Clinical spectum of tuberculous optic neuropathy 

      Davis, Ellen J; Rathinam, Sivakumar R; Okada, Annabelle A; Tow, Sharon L; Petrushkin, Harry; Graham, Elizabeth M; Smith, Justine R (Springer-Verlag, 2012-05-22)
      Purpose Tuberculous optic neuropathy may follow infection with Mycobacterium tuberculosis or administration of the bacille Calmette–Guerin. However, this condition is not well described in the ophthalmic literature. Meth ...
    • Common Sequence Variation in the VEGFC Gene Is Associated with Diabetic Retinopathy and Diabetic Macular Edema 

      Kaidonis, Georgia; Burdon, Kathryn Penelope; Gillies, Mark; Abhary, Sotoodeh; Essex, Rohan; Chang, John H; Pal, Bishwanath; Pefkianaki, Maria; Daniell, Maria; Lake, Stewart; Petrovsky, Nikolai; Hewitt, Alex W; Jenkins, Alicia; Lamoureux, Ecosse L; Gleadle, Jonathan; Craig, Jamie E (Elsevier, 2015-06-11)
      Purpose To investigate associations between single nucleotide polymorphisms (SNPs) in the VEGFC gene and the development of diabetic retinopathy (DR) in white patients with type 1 diabetes mellitus (T1DM) or type 2 ...
    • A common variant near TGFBR3 is associated with primary open angle glaucoma 

      Li, Zheng; Allingham, R Rand; Nakano, Masakazu; Jia, Liyun; Chen, Yuhong; Ikeda, Yoko; Mani, Baskaran; Chen, Li-Jia; Kee, Changwon; Garway-Heath, David F; Sarangapani, Sripriya; Fuse, Nobuo; Abu-Amero, Khaled K; Huang, Chukai; Namburi, Prasanthi; Burdon, Kathryn Penelope; Perera, Shamira A; Gharahkhani, Puya; Lin, Ying; Ueno, Morio; Ozaki, Mineo; Mizoguchi, Takanori; Krishnadas, Subbiah Ramasamy; Osman, Essam A; Lee, Mei Chin; Chan, Anita S Y; Tajudin, Liza-Sharmini A; Do, Tan; Goncalves, Aurelien; Reynier, Pascal; Zhang, Hong; Bourne, Rupert R A; Goh, David; Broadway, David; Husain, Rahat; Negi, Anil K; Su, Daniel H; Ho, Ching-Lin; Blanco, Augusto Azuara; Leung, Christopher K C; Wong, Tina T; Yakub, Azhany; Liu, Yutao; Nongpiur, Monisha E; Han, Jong Chul; Hon, Do Nhu; Shantha, Balekudaru; Zhao, Bowen; Sang, Jinghong; Zhang, NiHong; Consortium, ICAARE-Glaucoma; Neighborhood Consortium; Hewitt, Alex W; Mackey, David A; Craig, Jamie E; et. al. (Oxford University Press, 2015)
      Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution.We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with ...
    • Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma 

      Gharahkhani, Puya; Burdon, Kathryn Penelope; Fogarty, Rhys Daniel; Sharma, Shiwani; Hewitt, Alex W; Martin, Sarah; Law, Matthew H; Cremin, Katie; Cooke-Bailey, Jessica N; Loomis, Stephanie J; Pasquale, Louis R; Haines, Jonathan L; Hauser, Michael A; Viswanathan, Ananth C; McGuffin, Peter W; Topouzis, Fotis; Foster, Paul J; Graham, Stuart L; Casson, Robert J; Chehade, Mark; White, Andrew J; Zhou, Tiger; Souzeau, Emmanuelle; Landers, John; Fitzgerald, Jude T; Klebe, Sonja; Ruddle, Jonathan B; Goldberg, Ivan; Healey, Paul R; Wellcome Trust Case Control Consortium; Neighborhood Consortium; Mills, Richard Arthur; Wang, Jie Jin; Montgomery, Grant W; Martin, Nicholas G; Radford-Smith, Graham; Whiteman, David C; Brown, Matthew A; Wiggs, Janey L; Mackey, David A; Mitchell, Paul; MacGregor, Stuart; Craig, Jamie E (Nature Publishing Group, 2014-10)
      Primary open-angle glaucoma (POAG) is a major cause of irreversible blindness worldwide. We performed a genome-wide association study in an Australian discovery cohort comprising 1,155 cases with advanced POAG and 1,992 ...
    • Comparative outcomes of penetrating and component endothelial cell corneal allografts in outbred sheep 

      Mills, Richard Arthur; Klebe, Sonja; Coster, Douglas John; Williams, Keryn Anne (Cognizant Communication Corporation, 2012-12-04)
      Lamellar (component-cell) corneal transplantation is replacing penetrating keratoplasty for some corneal disorders in humans; but the relative risks of immunological graft rejection for the two procedures are uncertain. A ...
    • Comparing the effectiveness of selective laser trabeculoplasty with topical medication as initial treatment (the Glaucoma Initial Treatment Study): study protocol for a randomised controlled trial 

      Lamoureux, Ecosse L; Mcintosh, Rachel; Constantinou, Marios; Fenwick, Eva K; Xie, Jing (Centre for Eye Research Australia); Casson, Robert J; Finkelstein, Eric; Goldberg, Ivan; Healey, Paul; Thomas, Constantinou; Ang, Ghee Soon; Pesudovs, Konrad; Crowston, Jonathan (BioMed Central, 2015-09-11)
      Background Glaucoma is the leading cause of irreversible blindness in the world. Estimated to affect 60 million people worldwide, this figure is expected to rise to 80 million by 2020. Untreated, glaucoma leads to visual ...
    • A comparison of endothelial and penetrating keratoplasty outcomes following failed penetrating keratoplasty: a registry study 

      Keane, Miriam Claire; Galettis, Rachel A; Mills, Richard Arthur; Coster, Douglas John; Williams, Keryn Anne; Australian Corneal Graft Registry, Contributors (BMJ Publishing Group, 2016)
      Purpose To compare graft survival and visual outcomes for endothelial keratoplasty (EK) after a first penetrating keratoplasty (PK), with outcomes of repeat PK after a first PK. Methods 400 eyes with a second graft (65 ...
    • A Comparison of Lamellar and Penetrating Keratoplasty Outcomes: A Registry Study 

      Coster, Douglas John; Lowe, Marie; Keane, Miriam Claire; Williams, Keryn Anne (Elsevier, 2014-02)
    • A Comparison of Measures of Endothelial Function in Patients with Peripheral Arterial Disease and Age and Gender Matched Controls 

      Allan, Richard B; Vun, Simon V; Spark, James Ian (Hindawi, 2016-01-31)
      This study compared flow-mediated dilatation (FMD), peripheral artery tonometry (PAT), and serum nitric oxide (NO) measures of endothelial function in patients with peripheral artery disease (PAD) against age/gender matched ...
    • Compound heterozygote myocilin mutations in a pedigree with high prevalence of primary open-angle glaucoma 

      Young, Thomas K; Souzeau, Emmanuelle; Liu, Lance; Kearns, Lisa S; Burdon, Kathryn Penelope; Craig, Jamie E; Ruddle, Jonathan B (Emory Eye Centre, 2012-12-28)
      Purpose: To describe the phenotype of ocular hypertension and primary open-angle glaucoma in a family with individuals compound heterozygote for Gln368STOP and Thr377Met myocilin (MYOC) mutations. Methods: Family members ...
    • A comprehensive comparison of central corneal thickness measurement 

      Huang, Jinhai; Pesudovs, Konrad; Yu, Ayong; Wright, Thomas; Wen, Daizong; Li, Ming; Yu, Ye; Wang, Qinmei (Lippincott Williams & Wilkins, 2011-03)
      Purpose. To assess the repeatability and reproducibility of central corneal thickness (CCT) measurements by high-resolution rotating Scheimpflug imaging (Pentacam, Oculus) and Fourier-domain optical coherence tomography ...
    • A Comprehensive Evaluation of the Precision (Repeatability and Reproducibility) of the Oculus Pentacam HR 

      McAlinden, Colm; Khadka, Jyoti; Pesudovs, Konrad (Association for Research in Vision and Ophthalmology, Inc., 2011-09)
      Purpose.: To evaluate the precision (repeatability and reproducibility) of the Pentacam HR (high-resolution) tomographer (Oculus, Wetzlar, Germany) across a large range of measurement parameters. Methods.: A randomly ...
    • Contrast and glare testing in keratoconus and after penetratin keratoplasty 

      Pesudovs, Konrad; Schoneveld, P; Seto, R J; Coster, Douglas John (BMJ Publishing Group - http://bjo.bmjjournals.com/, 2004-05)
      AIM: To compare the performance of keratoconus, penetrating keratoplasty (PK), and control subjects on clinical tests of contrast and glare vision, to determine whether differences in vision were independent of visual ...
    • Contribution of Mutations in Known Mendelian Glaucoma Genes to Advanced Early-Onset Primary Open-Angle Glaucoma 

      Zhou, Tiger; Souzeau, Emmanuelle; Siggs, Owen M; Landers, John; Mills, Richard Arthur; Goldberg, Ivan; Healey, Paul R; Graham, Stuart L; Hewitt, Alex W; Mackey, David A; Galanopoulos, Anna; Casson, Robert J; Ruddle, Jonathan B; Ellis, Jonathan; Leo, Jonathan; Brown, Matthew A; MacGregor, Stuart; Sharma, Shiwani; Burdon, Kathryn Penelope; Simmonds, Jamie E (Association for Research in Vision and Ophthalmology, Inc., 2017-03)
      Purpose: Primary open-angle glaucoma (POAG) and primary congenital glaucoma (PCG) with Mendelian inheritance are caused by mutations in at least nine genes. Utilizing whole-exome sequencing, we examined the disease burden ...
    • Controlled drug delivery from composites of nanostructured porous silicon and poly(L-lactide) 

      McInnes, Steven James; Irani, Yazad; Williams, Keryn Anne; Voelcker, Nicolas Hans (Future Medicine, 2012-03-06)
      Porous silicon (pSi) and poly(l-lactide) (PLLA) both display good biocompatibility and tunable degradation behavior, suggesting that composites of both materials are suitable candidates as biomaterials for localized drug ...
    • Copy Number Variations of TBK1 in Australian Patients With Primary Open-Angle Glaucoma 

      Awadalla, Mona S; Fingert, John H; Roos, Benjamin R; Chen, Simon; Holmes, Richard; Graham, Stuart L; Chehade, Mark; Galanopoulos, Anna; Ridge, Bronwyn; Souzeau, Emmanuelle; Zhou, Tiger; Siggs, Owen M; Hewitt, Alex W; Mackey, David A; Burdon, Kathryn Penelope; Craig, Jamie E (Elsevier, 2015-01)
      PURPOSE To investigate the presence of TBK1 copy number variations in a large, well-characterized Australian cohort of patients with glaucoma comprising both normal-tension glaucoma and high-tension glaucoma cases. DESIGN A ...
    • Corneal transplantation for keratoconus: a registry study. 

      Kelly, Thu-Lan; Williams, Keryn Anne; Coster, Douglas John (American Medical Association, 2011-06)
      To determine factors influencing long-term graft survival and visual acuity in 4834 eyes of 4060 patients receiving their first penetrating corneal graft for keratoconus, a large cohort study was performed from a national ...