Now showing items 1-20 of 166

    • Accurate Imputation-Based Screening of Gln368Ter Myocilin Variant in Primary Open-Angle Glaucoma 

      Gharahkhani, Puya; Burdon, Kathryn Penelope; Hewitt, Alex W; Law, Matthew H; Souzeau, Emmanuelle; Montgomery, Grant W; Radford-Smith, Graham; Mackey, David A; Craig, Jamie E; MacGregor, Stuart (Association for Research in Vision and Ophthalmology, 2015-08)
      PURPOSE: Myocilin (MYOC) is a well-established primary open-angle glaucoma (POAG) risk gene, with rare variants known to have high penetrance. The most common clinically relevant risk variant, Gln368Ter, has an allele ...
    • Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma 

      Gharahkhani, Puya; Burdon, Kathryn Penelope; Cooke-Bailey, Jessica N; Hewitt, Alex W; Law, Matthew H; Pasquale, Louis R; Kang, Jae Hee; Haines, Jonathan L; Souzeau, Emmanuelle; Zhou, Tiger; Siggs, Owen M; Landers, John; Awadalla, Mona S; Sharma, Shiwani; Mills, Richard Arthur; Ridge, Bronwyn; Lynn, David J; Casson, Robert J; Graham, Stuart L; Goldberg, Ivan; White, Andrew J; Healey, Paul R; Grigg, John RB; Lawlor, Mitchell; Mitchell, Paul; Ruddle, Jonathan B; Coote, Michael A; Walland, Mark; Best, Stephen; Vincent, Andrea; Gale, Jesse; Radford-Smith, Graham; Whiteman, David C; Montgomery, Grant W; Martin, Nicholas G; Mackey, David A; Wiggs, Janey L; MacGregor, Stuart; Craig, Jamie E; Neighborhood Consortium (Nature Publishing Group, 2018-02-18)
      Exfoliation syndrome (XFS) is the most common known risk factor for secondary glaucoma and a major cause of blindness worldwide. Variants in two genes, LOXL1 and CACNA1A, have previously been associated with XFS. To further ...
    • Angiogenic and Immunologic Proteins Identified by Deep Proteomic Profiling of Human Retinal and Choroidal Vascular Endothelial Cells: Potential Targets for New Biologic Drugs 

      Smith, Justine R; David, Larry L; Appukuttan, Binoy; Wilmarth, Phillip A (Elsevier, 2018-03-17)
      Purpose Diseases that involve retinal or choroidal vascular endothelial cells are leading causes of vision loss: age-related macular degeneration, retinal ischemic vasculopathies, and noninfectious posterior uveitis. ...
    • Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity 

      Souma, Tomokazu; Tompson, Stuart W; Thomson, Benjamin R; Siggs, Owen M; Kizhatil, Krishnakumar; Yamaguchi, Shinji; Feng, Liang; Limviphuvadh, Vachiranee; Whisenhunt, Kristina N; Maurer-Stroh, Sebastian; Yanovitch, Tammy L; Kalaydijieva, Luba; Azmanov, Dimitar N; Finzi, Simone; Mauri, Lucia; Javadiyan, Shahrbanou; Souzeau, Emmanuelle; Zhou, Tiger; Hewitt, Alex W; Kloss, Bethany; Burdon, Kathryn Penelope; Mackey, David A; Allen, Keri F; Ruddle, Jonathan B; Lim, Sing-Hui; Rozen, Steve; Tran-Viet, Khanh-Nhat; Liu, Xiaorong; John, Simon; Wiggs, Janey L; Pasutto, Francesca; Craig, Jamie E; Jin, Jing; Quaggin, Susan; Young, Terri L (American Society for Clinical Investigation, 2016)
      Primary congenital glaucoma (PCG) is a devastating eye disease and an important cause of childhood blindness worldwide. In PCG, defects in the anterior chamber aqueous humor outflow structures of the eye result in elevated ...
    • Angiopoietin-1 is required for Schlemm’s canal development in mice and humans 

      Thomson, Benjamin R; Souma, Tomokazu; Tompson, Stuart W; Onay, Tuncer; Kizhatil, Krishnakumar; Siggs, Owen M; Feng, Liang; Whisenhunt, Kristina N; Yanovitch, Tammy L; Kalaydjieva, Luba; Azmanov, Dimitar N; Finzi, Simone; Tanna, Christine A; Hewitt, Alex W; Mackey, David A; Bradfield, Yasmin S; Souzeau, Emmanuelle; Javadiyan, Shahrbanou; Wiggs, Janey L; Pasutto, Francesca; Liu, Xiaorong; John, Simon W M; Craig, Jamie E; Jin, Jing; Young, Terri L; Quaggin, Susan (American Society for Clinical Investigation, 2017-11)
      Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures, Schlemm’s canal (SC) and the trabecular meshwork. We ...
    • An Anti–VEGF-B Antibody Fragment Induces Regression of Pre-Existing Blood Vessels in the Rat Cornea 

      Irani, Yazad; Scotney, Pierre; Klebe, Sonja; Mortimer, Lauren A; Nash, Andrew; Williams, Keryn Anne (ARVO Journals, 2017-07)
      Purpose: We tested the ability of an antibody fragment with specificity for vascular endothelial growth factor-B (VEGF-B) to regress nascent and established corneal blood vessels in the rat. Methods: A single chain variable ...
    • Assessment of Cataract Surgery Outcome Using the Modified Catquest Short-Form Instrument in China 

      Khadka, Jyoti; Huang, Jinhai; Chen, Haisi; Chen, Chengwei; Gao, Rongrong; Bao, Fangjun; Zhang, Sifang; Wang, Qinmei; Pesudovs, Konrad (PLOS, 2016-10-13)
    • Assessment of corneal thickness measurement using swept-source Fourier-domain anterior segment optical coherence tomography and Scheimpflug camera 

      Huang, Jinhai; Feng, Yifan; Wang, Qinmei; Pesudovs, Konrad (Elsevier, 2012-07-01)
      No abstract available
    • Assessment of polygenic effects links primary open-angle glaucoma and age-related macular degeneration 

      Cuellar-Partida, Gabriel; Craig, Jamie E; Burdon, Kathryn Penelope; Wang, Jie Jin; Vote, Brendan J; Souzeau, Emmanuelle; McAllister, Ian L; Isaacs, Timothy; Lake, Stewart; Mackey, David A; Constable, Ian J; Mitchell, Paul; Hewitt, Alex W; MacGregor, Stuart (Nature Publishing Group, 2016)
      Primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD) are leading causes of irreversible blindness. Several loci have been mapped using genome-wide association studies. Until very recently, there ...
    • Association of eNOS polymorphisms with primary angle-closure glaucoma 

      Awadalla, Mona S; Thapa, Suman S; Hewitt, Alex W; Craig, Jamie E; Burdon, Kathryn Penelope (Association for Research in Vision and Ophthalmology, 2013-03)
      Purpose: Recently, several studies have investigated genetic associations between Cytochrome P450 (CYP1B1), Endothelial nitric oxide synthase (eNOS) and Neurotrophin-4 (NTF4) with primary angle-closure glaucoma (PACG) in ...
    • Association of genetic variants in the TMCO1 gene with clinical parameters related to glaucoma and characterisation of the protein in the eye 

      Sharma, Shiwani; Burdon, Kathryn Penelope; Chidlow, Glyn; Klebe, Sonja; Crawford, April; Dimasi, David Paul; Dave, Alpana; Martin, Sarah; Javadiyan, Shahrbanou; Wood, John P M; Casson, Robert J; Danoy, Patrick; Griggs, Kim Marie; Hewitt, Alex W; Landers, John; Mitchell, Paul; Mackey, David A; Craig, Jamie E (Association for Research in Vision and Ophthalmology, 2012-06-06)
      Purpose. Glaucoma is the leading cause of irreversible blindness worldwide. Primary open angle glaucoma (POAG) is the most common subtype. We recently reported association of genetic variants at chromosomal loci, 1q24 and ...
    • Association of genetic variants with primary angle closure glaucoma in two different populations 

      Awadalla, Mona S; Thapa, Suman S; Hewitt, Alex W; Burdon, Kathryn Penelope; Craig, Jamie E (Public Library of Science, 2013)
      PURPOSE: A recent large genome-wide association study (GWAS) identified multiple variants associated with primary angle-closure glaucoma (PACG). The present study investigated the role of these variants in two cohorts ...
    • Association of open-angle glaucoma loci with incident glaucoma in the Blue Mountains Eye Study. 

      Burdon, Kathryn Penelope; Mitchell, Paul; Lee, Anne; Healey, Paul R; White, Andrew J; Rochtchina, Elena; Thomas, P; Wang, Jie Jin; Craig, Jamie E (Elsevier Inc., 2015)
      PURPOSE: To determine if open-angle glaucoma (OAG)-associated single nucleotide polymorphisms (SNPs) are associated with incident glaucoma and if such genetic information is useful in OAG risk prediction. DESIGN: ...
    • Australian and New Zealand Registry of Advanced Glaucoma: methodology and recruitment 

      Souzeau, Emmanuelle; Goldberg, Ivan; Healey, Paul R; Mills, Richard Arthur; Landers, John; Graham, Stuart L; Grigg, John RB; Usher, Bronwyn; Straga, Tania; Crawford, April; Casson, Robert J; Morgan, William H; Ruddle, Jonathan B; Coote, Michael A; White, Andrew J; Stewart, James; Hewitt, Alex W; Mackey, David A; Burdon, Kathryn Penelope; Craig, Jamie E (Wiley-Blackwell, 2013-08-13)
      Glaucoma is a sight-threatening disease affecting 3% of the population over the age of 50. Glaucoma is treatable, and severe vision loss can usually be prevented if diagnosis is made at an early stage. Genetic factors play ...
    • The Australian Corneal Graft Registry 2004 annual report 

      Williams, Keryn Anne; Hornsby, Ngaere B; Bartlett, Christine Mary; Holland, Helene K; Esterman, Adrian Jeffrey; Coster, Douglas John (2006-06-20)
      The Australian Corneal Graft Registry (ACGR) opened in May 1985 and has now been in operation for 18 years. In that time, we have collected data on over 14,000 corneal grafts. At the time of transplantation, we seek ...
    • The Australian Corneal Graft Registry 2007 Report 

      Williams, Keryn Anne; Lowe, Marie Therese; Bartlett, Christine Mary; Kelly, L; Coster, Douglas John (Flinders University Press, 2007)
      The Australian Corneal Graft Registry opened in May 1985 and thus has now been in operation for over 22 years. The census date for this report was 01/09/2006. Over the years, we have collected data on more than 18,500 ...
    • The Australian Corneal Graft Registry 2012 Report 

      Williams, Keryn Anne; Lowe, Marie Therese; Keane, Miriam Claire; Jones, Victoria J; Loh, Raymond S K; Coster, Douglas John (2012-03-05)
      The Australian Corneal Graft Registry (ACGR) opened in May 1985 and thus has now been in operation for over 26 years. However, the census dates for this report was 01/06/2010 for penetrating grafts and 12/10/2011 for ...
    • The Australian Corneal Graft Registry 2012 Report 

      Williams, Keryn Anne; Lowe, Marie Therese; Keane, Miriam Claire; Jones, Victoria J; Loh, Raymond S K; Coster, Douglas John (2012-03-09)
      The Australian Corneal Graft Registry (ACGR) opened in May 1985 and thus has now been in operation for over 26 years. However, the census dates for this report was 01/06/2010 for penetrating grafts and 12/10/2011 for ...
    • The Australian Corneal Graft Registry 2015 Report 

      Williams, Keryn Anne; Keane, Miriam Claire; Galettis, Rachel A; Jones, Victoria J; Mills, Richard Arthur; Coster, Douglas John (South Australian Health and Medical Research Institute, 2015-06-15)
      The Australian Corneal Graft Registry (ACGR) opened in May 1985 and has now been operating for 30 years. Over the years, we have collected information on more than 30,000 corneal grafts. At registration, we seek information ...
    • The Australian Corneal Graft Registry 2018 Report 

      Williams, Keryn Anne; Keane, Miriam Claire; Coffey, Nora Elizabeth; Jones, Victoria Jane; Mills, Richard Arthur; Coster, Douglas John (South Australian Health and Medical Research Institute, 2018)
      The Australian Corneal Graft Registry (ACGR) opened in May 1985 and has now been operating for 33 years. Over the years, we have collected information on more than 35,000 corneal grafts. At registration, we seek information ...