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    • An Intraocular Pressure Polygenic Risk Score Stratifies Multiple Primary Open-Angle Glaucoma Parameters Including Treatment Intensity 

      Qassim, Ayub; Souzeau, Emmanuelle; Siggs, Owen M; Hassall, Mark M; Han, Xikun; Griffiths, Helen L; Frost, N Andrew; Vallabh, Neeru A; Kirwan, James F; Menon, Geeta; Cree, Angela J; Galanopoulos, Anna; Agar, Ashish; Healey, Paul R; Graham, Stuart L; Landers, John; Casson, Robert J; Gharahkhani, Puya; Willoughby, Colin E; Hewitt, Alex W; Lotery, Andrew J; MacGregor, Stuart; Craig, Jamie E (Elsevier, 2020-01)
      Purpose To examine the combined effects of common genetic variants associated with intraocular pressure (IOP) on primary open-angle glaucoma (POAG) phenotype using a polygenic risk score (PRS) stratification. Design ...