Now showing items 1-9 of 9

    • Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma 

      Gharahkhani, Puya; Burdon, Kathryn Penelope; Fogarty, Rhys Daniel; Sharma, Shiwani; Hewitt, Alex W; Martin, Sarah; Law, Matthew H; Cremin, Katie; Cooke-Bailey, Jessica N; Loomis, Stephanie J; Pasquale, Louis R; Haines, Jonathan L; Hauser, Michael A; Viswanathan, Ananth C; McGuffin, Peter W; Topouzis, Fotis; Foster, Paul J; Graham, Stuart L; Casson, Robert J; Chehade, Mark; White, Andrew J; Zhou, Tiger; Souzeau, Emmanuelle; Landers, John; Fitzgerald, Jude T; Klebe, Sonja; Ruddle, Jonathan B; Goldberg, Ivan; Healey, Paul R; Wellcome Trust Case Control Consortium; Neighborhood Consortium; Mills, Richard Arthur; Wang, Jie Jin; Montgomery, Grant W; Martin, Nicholas G; Radford-Smith, Graham; Whiteman, David C; Brown, Matthew A; Wiggs, Janey L; Mackey, David A; Mitchell, Paul; MacGregor, Stuart; Craig, Jamie E (Nature Publishing Group, 2014-10)
      Primary open-angle glaucoma (POAG) is a major cause of irreversible blindness worldwide. We performed a genome-wide association study in an Australian discovery cohort comprising 1,155 cases with advanced POAG and 1,992 ...
    • A Comparison of Lamellar and Penetrating Keratoplasty Outcomes: A Registry Study 

      Coster, Douglas John; Lowe, Marie; Keane, Miriam Claire; Williams, Keryn Anne (Elsevier, 2014-02)
    • A cross-ethnicity investigation of genes previously implicated in primary angle closure glaucoma 

      Awadalla, Mona S; Burdon, Kathryn Penelope; Thapa, Suman S; Hewitt, Alex W; Craig, Jamie E (Emory Eye Centre, 2012)
      Purpose: To investigate the underlying genetic variation between candidate genes and primary angle closure glaucoma (PACG) in both Nepalese and Australian populations. Methods: A total of 213 patients with PACG (106 Nepalese ...
    • Identification of a novel MYOC mutation, p.Trp373X, in a family with open angle glaucoma 

      Crawford, April; Souzeau, Emmanuelle; Agar, Ashish; Ridge, Bronwyn; Dubowsky, Andrew; Burdon, Kathryn Penelope; Craig, Jamie E (Elsevier, 2014)
    • Macular hypoplasia in congenital disorder of glycosylation type 1a 

      Wang, Bob Z; Siriwardana, Pradeep; Taranath, Deepa A (S. Karger, Basel, 2012)
      Congenital disorders of glycosylation are a rare group of metabolic disorders that can result in multiorgan disease. This article describes a novel finding of macular hypoplasia in congenital disorders of glycosylation type 1a.
    • Patient-centred measurement in ophthalmology - a paradigm shift 

      Pesudovs, Konrad (BioMed Central - http://www.biomedcentral.com, 2006-06)
      Ophthalmologists and researchers in ophthalmology understand what a rapidly evolving field ophthalmology is, and that to conduct good research it is essential to use the latest and best methods. In outcomes research, one ...
    • A Proposed Minimum Standard Set of Outcome Measures for Cataract Surgery 

      Mahmud, Imran; Kelley, Thomas; Stowell, Caleb; Haripriya, Aravind; Boman, Anders; Kossler, Ingrid; Morlet, Nigel; Pershing, Suzann; Pesudovs, Konrad; Goh, Pik Pin; Sparrow, John M; Lundstrom, Mats (American Medical Association, 2015-08-20)
      Importance Aligning outcome measures for cataract surgery, one of the most frequently performed procedures globally, may facilitate international comparisons that can drive improvements in the outcomes most meaningful to ...
    • The related transcriptional enhancer factor-1 isoform, TEAD4 216, can repress vascular endothelial growth factor expression in mammalian cells 

      Appukuttan, Binoy; McFarland, Trevor J; Stempel, Andrew; Kassem, Jean B; Hartzell, Matthew; Zhang, Yi; Bond, Derek; West, Kelsey; Wilson, Reid; Stout, Andrew; Pan, Yuzhen; Ilias, Hoda; Robertson, Kathryn; Klein, Michael L; Wilson, David; Smith, Justine R; Stout, J Timothy (Public Library of Science, 2012-06-22)
      Increased cellular production of vascular endothelial growth factor (VEGF) is responsible for the development and progression of multiple cancers and other neovascular conditions, and therapies targeting post-translational ...
    • Visual Performance in Patients with Neovascular Age-Related Macular Degeneration Undergoing Treatment with Intravitreal Ranibizumab 

      Sabour-Pickett, S; Loughman, J; Nolan, J M; Stack, J; Pesudovs, Konrad; Meagher, K A; Beatty, S (Hindawi Publishing Corporation, 2013)
      Purpose. To assess visual function and its response to serial intravitreal ranibizumab (Lucentis, Genentech) in patients with neovascular age-related macular degeneration (nv-AMD). Methods. Forty-seven eyes of 47 patients ...