Now showing items 1-20 of 21

    • Association of genetic variants in the TMCO1 gene with clinical parameters related to glaucoma and characterisation of the protein in the eye 

      Sharma, Shiwani; Burdon, Kathryn Penelope; Chidlow, Glyn; Klebe, Sonja; Crawford, April; Dimasi, David Paul; Dave, Alpana; Martin, Sarah; Javadiyan, Shahrbanou; Wood, John P M; Casson, Robert J; Danoy, Patrick; Griggs, Kim Marie; Hewitt, Alex W; Landers, John; Mitchell, Paul; Mackey, David A; Craig, Jamie E (Association for Research in Vision and Ophthalmology, 2012-06-06)
      Purpose. Glaucoma is the leading cause of irreversible blindness worldwide. Primary open angle glaucoma (POAG) is the most common subtype. We recently reported association of genetic variants at chromosomal loci, 1q24 and ...
    • Australian and New Zealand Registry of Advanced Glaucoma: methodology and recruitment 

      Souzeau, Emmanuelle; Goldberg, Ivan; Healey, Paul R; Mills, Richard Arthur; Landers, John; Graham, Stuart L; Grigg, John RB; Usher, Bronwyn; Straga, Tania; Crawford, April; Casson, Robert J; Morgan, William H; Ruddle, Jonathan B; Coote, Michael A; White, Andrew J; Stewart, James; Hewitt, Alex W; Mackey, David A; Burdon, Kathryn Penelope; Craig, Jamie E (Wiley-Blackwell, 2013-08-13)
      Glaucoma is a sight-threatening disease affecting 3% of the population over the age of 50. Glaucoma is treatable, and severe vision loss can usually be prevented if diagnosis is made at an early stage. Genetic factors play ...
    • Characterization of serous retinal detachments in uveitis patients with optical coherence tomography 

      Simmons-Rear, Annamieka; Yeh, Steven; Chan-Kai, Brian T; Lauer, Andreas K; Flaxel, Christina J; Smith, Justine R; Rosenbaum, James T; Suhler, Eric B (Springer-Verlag, 2012-06-02)
      To determine the prevalence of serous retinal detachments (SRD) using optical coherence tomography (OCT) in a large database of patients with uveitis from a tertiary referral setting, to describe clinical features of ...
    • Clinical spectum of tuberculous optic neuropathy 

      Davis, Ellen J; Rathinam, Sivakumar R; Okada, Annabelle A; Tow, Sharon L; Petrushkin, Harry; Graham, Elizabeth M; Smith, Justine R (Springer-Verlag, 2012-05-22)
      Purpose Tuberculous optic neuropathy may follow infection with Mycobacterium tuberculosis or administration of the bacille Calmette–Guerin. However, this condition is not well described in the ophthalmic literature. Meth ...
    • Comparative outcomes of penetrating and component endothelial cell corneal allografts in outbred sheep 

      Mills, Richard Arthur; Klebe, Sonja; Coster, Douglas John; Williams, Keryn Anne (Cognizant Communication Corporation, 2012-12-04)
      Lamellar (component-cell) corneal transplantation is replacing penetrating keratoplasty for some corneal disorders in humans; but the relative risks of immunological graft rejection for the two procedures are uncertain. A ...
    • Compound heterozygote myocilin mutations in a pedigree with high prevalence of primary open-angle glaucoma 

      Young, Thomas K; Souzeau, Emmanuelle; Liu, Lance; Kearns, Lisa S; Burdon, Kathryn Penelope; Craig, Jamie E; Ruddle, Jonathan B (Emory Eye Centre, 2012-12-28)
      Purpose: To describe the phenotype of ocular hypertension and primary open-angle glaucoma in a family with individuals compound heterozygote for Gln368STOP and Thr377Met myocilin (MYOC) mutations. Methods: Family members ...
    • Controlled drug delivery from composites of nanostructured porous silicon and poly(L-lactide) 

      McInnes, Steven James; Irani, Yazad; Williams, Keryn Anne; Voelcker, Nicolas Hans (Future Medicine, 2012-03-06)
      Porous silicon (pSi) and poly(l-lactide) (PLLA) both display good biocompatibility and tunable degradation behavior, suggesting that composites of both materials are suitable candidates as biomaterials for localized drug ...
    • Corneal transplantation for keratoconus: a registry study. 

      Kelly, Thu-Lan; Williams, Keryn Anne; Coster, Douglas John (American Medical Association, 2011-06)
      To determine factors influencing long-term graft survival and visual acuity in 4834 eyes of 4060 patients receiving their first penetrating corneal graft for keratoconus, a large cohort study was performed from a national ...
    • Effectiveness of the community-based Low Vision Service Wales: a long-term outcome study 

      Ryan, Barbara; Khadka, Jyoti; Bunce, Catey; Court, Helen (BMJ Group, 2013-02-14)
      Aims To evaluate the long-term effectiveness of the community-based Low Vision Service Wales (LVSW). Methods A long-term observational study of the Government-funded, community-based, low-vision rehabilitation service ...
    • Epigenetic effects on eye diseases 

      Hewitt, Alex W; Wang, Jie Jin; Liang, Helena; Craig, Jamie E (Informa Plc, 2012-04)
      Epigenetics is the process by which patterns of gene expression are modified in a mitotically heritable manner. However, these epigenetic variations are not attributable to changes in the primary nucleotide sequence within ...
    • Expression of an anti-CD4 single-chain antibody fragment from the donor cornea can prolong corneal allograft survival in inbred rats 

      Appleby, Sarah Louise; Jessup, Claire Frances; Mortimer, Lauren A; Kirk, Kirsty; Brereton, Helen Mary; Coster, Douglas John; Tan, Chuan K; Williams, Keryn Anne (BMJ Group, 2012-11-21)
      To investigate whether expression of an anti-CD4 antibody fragment (scFv) by a lentivector-transduced donor cornea can prolong rat corneal allograft survival. Methods Inbred Fischer 344 rats received penetrating corneal ...
    • Gene therapy for corneal dystrophies and disease, where are we? 

      Williams, Keryn Anne; Klebe, Sonja (Lippincott Williams & Wilkins, 2012-07)
      We assess studies on vector systems for delivery of transgenes to the cornea that have been published over the last year, and summarise new work on the identification of specific transgenes for corneal diseases. Recent ...
    • Genetic study of Diabetic Retinopathy: recruitment methodology and analysis of baseline characteristics 

      Kaidonis, Georgia; Abhary, Sotoodeh; Daniell, Mark; Gillies, Mark; Fogarty, Rhys Daniel; Petrovsky, Nikolai; Jenkins, Alicia; Essex, Rohan; Chang, John H; Pal, Bishwanath; Hewitt, Alex W; Burdon, Kathryn Penelope; Craig, Jamie E (Wiley-Blackwell, 2013-09-30)
      BACKGROUND: Diabetic retinopathy (DR) is a blinding disease of increasing prevalence, caused by a complex interplay of genetic and environmental factors. Here we describe the patient recruitment methodology, case and control ...
    • Identification of a novel oligomerization disrupting mutation in CRYAA associated with congenital cataract in a South Australian family 

      Laurie, Kate; Dave, Alpana; Straga, Tania; Souzeau, Emmanuelle; Chataway, Timothy Kennion; Sykes, Matthew James; Casey, Theresa; Teo, Theodosia; Pater, John Brian; Craig, Jamie E; Sharma, Shiwani; Burdon, Kathryn Penelope (Wiley-Blackwell, 2013-03)
      Congenital cataract is a heterogeneous disorder causing severe visual impairment in affected children. We screened four South Australian families with autosomal dominant congenital cataract for mutations in 10 crystallin ...
    • The influence of Australian eye banking practices on corneal graft survival 

      Keane, Miriam Claire; Lowe, Marie T; Coster, Douglas John; Pollock, Graeme A; Williams, Keryn Anne (Australasian Medical Publishing Company, 2013-08-19)
      Donor corneas transported interstate exhibited poorer survival after transplantation than those retrieved and grafted locally. Higher proportions of emergency procedures involving transported corneas did not account for ...
    • The influence of cervical and thoracic lymphadenectomy on corneal allograft rejection in inbred rats 

      Brice, Sarah L; Kirk, Kirsty; Brereton, Helen Mary; Coster, Douglas John; Williams, Keryn Anne (BMJ Group, 2011-11-23)
      Aim To investigate the site of alloantigen presentation in the rat following orthotopic corneal transplantation. Methods Adult inbred Fischer 344 rats received penetrating corneal allografts from inbred Wistar Furth donors ...
    • Neuroretinitis following bull ant sting 

      Ullrich, Katja; Saha, Niladri; Lake, Stewart (BMJ Group, 2012)
      Cat scratch disease causes the majority of cases of neuroretinitis. Neuroretinitis is characterised by clinical features of papillitis, macular oedema and macular star. We report a case study of infection with Bartonella ...
    • Penetrating keratoplasty versus deep anterior lamellar keratoplasty for treating keratoconus 

      Keane, Miriam Claire; Williams, Keryn Anne; Coster, Douglas John (John Wiley and Sons Ltd, 2012-03-14)
      This is the protocol for a review and there is no abstract. The objectives are as follows: To compare visual outcomes after penetrating keratoplasty and DALK for keratoconus and identify the factors contributing to ...
    • The prevalence of glaucoma in indigenous Australians within Central Australia: the Central Australian Ocular Health Study 

      Landers, John; Henderson, Timothy R; Craig, Jamie E (BMJ Group, 2011-04-22)
      Aims To determine the prevalence of glaucoma within the indigenous Australian population living in central Australia. Methods 1884 individuals aged ≥20 years, living in one of 30 remote communities within the statistical ...
    • The reliability of single-field fundus photography in screening for diabetic retinopathy: the Central Australian Ocular Health Study 

      Ku, Janice J-Y; Landers, John; Henderson, Timothy R; Craig, Jamie E (MJA Group Australia, 2012-10-26)
      Objective: To assess the accuracy of grading diabetic retinopathy (DR) using single-field digital fundus photography compared with clinical grading from a dilated slit-lamp fundus examination in Indigenous Australians ...