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The evidence base for oxygen for chronic refractory breathlessness: issues, gaps, and a future work plan
Breathlessness or “shortness of breath”, medically termed dyspnoea, remains a devastating problem for many people and those who care for them. As a treatment intervention, administration of opioids to relieve breathlessness ...
An international initiative to create a collaborative for pharmacovigilance in hospice and palliative care clinical practice
(Mary Ann Liebert, Inc., 2012-02-21)
Background: Medication registration currently requires evidence of safety and efficacy from adequately powered phase 3 studies. Pharmacovigilance (phase 4 studies, postmarketing data, adverse drug reaction reporting) provide ...
Off-label prescribing in palliative care – a cross-sectional national survey of Palliative Medicine doctors
(SAGE Publications, 2012-11-05)
Background: Regulatory bodies including the European Medicines Agency register medications (formulation, route of administration) for specific clinical indications. Once registered, prescription is at clinicians’ discretion. ...