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Once-daily opioids for chronic dyspnea: a dose increment and pharmacovigilance study
Context Randomised controlled trials (RCTs) can answer questions of efficacy, but rarely generate a complete safety profile. Long term pharmacovigilance studies complement RCTs. Objectives Level I evidence supports short ...
The evidence base for oxygen for chronic refractory breathlessness: issues, gaps, and a future work plan
Breathlessness or “shortness of breath”, medically termed dyspnoea, remains a devastating problem for many people and those who care for them. As a treatment intervention, administration of opioids to relieve breathlessness ...