Flinders Centre for Innovation in Cancer
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Recent Submissions
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miR-200/375 control epithelial plasticity-associated alternative splicing by repressing the RNA-binding protein Quaking
(EMBO Press/Wiley, 2018-06-05)Members of the miR‐200 family are critical gatekeepers of the epithelial state, restraining expression of pro‐mesenchymal genes that drive epithelial–mesenchymal transition (EMT) and contribute to metastatic cancer ... -
Demand for Colonoscopy in Colorectal Cancer Screening Using a Quantitative Fecal Immunochemical Test and Age-Sex-Specific Thresholds for Test Positivity
(Elsevier, 2018-06)Background: Despite age and sex differences in fecal hemoglobin (f-Hb) concentrations, most fecal immunochemical test (FIT) screening programs use population-average cut-points for test positivity. The impact of age/sex-specific ... -
Health-Related Quality of Life among Women Breast Cancer Patients in Eastern China
(Hindawi, 2018-07-03)Objectives. Breast cancer is one of the major cancers in Chinese women. European Organization for Research and Treatment of Cancer Quality of Life Questionnaires (EORTC QLQ-C30 and QLQ-BR23) are now the most common and ... -
Prevalence, perceptions and predictors of alcohol consumption and abstinence among South Australian school students: a cross-sectional analysis
(BioMed Central, 2017-06-07)Background Alcohol consumption by young people (particularly early initiation) is a predictor for poorer health in later life. In addition, evidence now clearly shows a causal link between alcohol and cancer. This study ... -
Exploring the Potential of Anticipated Regret as an Emotional Cue to Improve Bowel Cancer Screening Uptake
(Hindawi Publishing Corporation, 2017-02-02)Objective. Bowel cancer is currently the second leading cause of cancer-related death in Australia and screening participation is suboptimal. This study examined the role of emotion in the form of anticipated regret (AR) ... -
In vitro inhibitory activities of selected Australian medicinal plant extracts against protein glycation, angiotensin converting enzyme (ACE) and digestive enzymes linked to type II diabetes
(BioMed Central, 2016-11-04)Background There is a need to develop potential new therapies for the management of diabetes and hypertension. Australian medicinal plants collected from the Kuuku I’yu (Northern Kaanju) homelands, Cape York Peninsula, ... -
What causes breast cancer? A systematic review of causal attributions among breast cancer survivors and how these compare to expert endorsed risks.
(Springer Verlag, 2014-07)Purpose. The aim of this paper was to review published research that analyzed causal attributions for breast cancer among women previously diagnosed with breast cancer. These attributions were compared with risk factors ... -
Modeling the cost-effectiveness of strategies for treating esophageal adenocarcinoma and high-grade dysplasia
(Springer-Verlag, 2012-08)Objective: To synthesize cost and health outcomes for current treatment pathways for esophageal adenocarcinoma and high grade dysplasia, and model comparative net clinical and economic benefits of alternative management ... -
Self-reported bowel screening rates in older Australians and the implications for public health screening programs.
(Australasian Medical Journal, 2013-08-31)BACKGROUND: This paper sought to determine the status of older Australians with regard to Bowel Cancer screening practices occurring outside of the National Bowel Cancer Screening Program. METHOD: A random sample ... -
Exploring the Validity of the Continuum of Resistance Model for Discriminating Early from Late and Non-uptake of Colorectal Cancer Screening: Implications for the Design of Invitation and Reminder Letters.
(Springer., 2013-12)Background The continuum of resistance model contends that respondents lie at one end of a continuum and non-respondents at the other with respect to factors demonstrated to impact on screening participation. Purpose The ... -
Ambivalence and its influence on participation and non-participation in screening for colorectal cancer
(SAGE, 2013-09)Colorectal cancer (CRC) is one of the most prevalent cancers worldwide, and an ideal target for early detection and prevention through cancer screening. Unfortunately, rates of participation in screening are less than ... -
Using the Transtheoretical Model of Behaviour Change to describe readiness to rescreen for colorectal cancer with Faecal Occult Blood Testing
(CSIRO Publishing, 2012)Issue addressed: This study used the Transtheoretical Model of Behaviour Change (TTM) to describe reparticipation in colorectal cancer (CRC) screening according to social cognitive and background variables. Methods: A ... -
Dietary red meat aggravates dextran sulfate sodium-induced colitis in mice whereas resistant starch attenuates inflammation
(Springer-Verlag, 2013-08-29)Although a genetic component has been identified as a risk factor for developing inflammatory bowel disease, there is evidence that dietary factors also play a role in the development of this disease. Aims The aim of this ... -
Comparing the effects of COX and non-COX-inhibiting NSAIDs on enhancement of apoptosis and inhibition of aberrant crypt foci formation in a rat colorectal cancer model
(International Institute of Anticancer Research, 2013)The protection against colorectal cancer (CRC) by non-steroidal anti-inflammatory drugs (NSAIDs) is in part dependent on inhibition of cyclooxygenase (COX). We compared the efficacy of the non-COX-inhibiting R flurbiprofen ... -
Sample preference for colorectal cancer screening tests: blood or stool?
(Scientific Research Publishing, 2012-08)Objective: Despite the high prevalence of CRC and the proven benefits of faecal sampling tests, participation rates in CRC screening are suboptimal. Literature has identified a number of barriers to participation, including ... -
Discovery and validation of molecular biomarkers for colorectal adenomas and cancer with application to blood testing
(Public Library of Science, 2012-01-19)Results: Genome-wide analysis uncovered reproducible gene expression signatures for both adenomas and cancers compared to controls. 386/489 (79%) of the adenoma and 439/529 (83%) of the adenocarcinoma biomarkers were ... -
Predictors of re-participation in faecal occult blood test-based screening for colorectal cancer
(National Cancer Center, Korea, 2012)Background: There is little information on longitudinal patterns of participation in faecal occult blood test (FOBT) based colorectal cancer (CRC) screening or on demographic or behavioural factors associated with participation ... -
Combination of selenium and green tea improves the efficacy of chemoprevention in a rat colorectal cancer model by modulating genetic and epigenetic biomarkers
(Public Library of Science, 2013-05-23)Dietary supplementation of selenium and green tea holds promise in cancer prevention. In this study, we evaluated the efficacies of selenium and green tea administered individually and in combination against colorectal ... -
Equity of colorectal cancer screening: which groups have inequitable participation and what can we do about it?
(CSIRO Publishing, 2011)The National Bowel Cancer Screening Program (NBCSP) offers population-based screening for colorectal cancer (CRC) across Australia. The aims of this paper were to highlight the inequities in CRC screening in South Australia ... -
Screening for colorectal cancer in remote, rural and metropolitan South Australia: analysis of the National Bowel Cancer Screening Program data
(Government of South Australia Department of Health, 2011)The early detection of colorectal cancer (CRC) is a major clinical and public health concern. CRC is now the second most commonly diagnosed cancer in Australia and has the second highest cancer mortality rate. Around ...
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