Identification of Residues That Confer Sugar Selectivity to UDP-Glycosyltransferase 3A (UGT3A) Enzymes
Lewis, Benjamin Cavell
Miners, John Oliver
Mackenzie, Peter Ian
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Background: Conjugation of sugars to chemicals by UGTs is a critical detoxification mechanism. Result: A single amino acid defines the differential sugar specificities of two related UGTs. Conclusion: Change of a single amino acid during primate evolution has generated a new capacity for small molecule glycosidation. Significance: Determinants of UGT sugar selectivity are currently poorly understood; novel glycosidation pathways may have important metabolic roles.
Author version made available in accordance with the publishers policy. This research was originally published in the Journal of Biological Chemistry. Meech, Robyn; Rogers, Anne; Zhuang, Lizhe; Lewis, Benjamin C.; Miners, John O.; Mackenzie, Peter I. Identification of Residues That Confer Sugar Selectivity to UDP-Glycosyltransferase 3A (UGT3A) Enzymes. Journal of Biological Chemistry. 2012. 287:24122-24130-pp. © the American Society for Biochemistry and Molecular Biology