Identification of Residues That Confer Sugar Selectivity to UDP-Glycosyltransferase 3A (UGT3A) Enzymes
Lewis, Benjamin Cavell
Miners, John Oliver
Mackenzie, Peter Ian
MetadataShow full item record
Background: Conjugation of sugars to chemicals by UGTs is a critical detoxification mechanism. Result: A single amino acid defines the differential sugar specificities of two related UGTs. Conclusion: Change of a single amino acid during primate evolution has generated a new capacity for small molecule glycosidation. Significance: Determinants of UGT sugar selectivity are currently poorly understood; novel glycosidation pathways may have important metabolic roles.