Show simple item record

dc.contributor.authorLindner, Helen
dc.contributor.authorHaier, Jorg
dc.contributor.authorWang, Zhe
dc.contributor.authorWatson, David Ian
dc.contributor.authorHussey, Damian James
dc.contributor.authorHummel, Richard
dc.date.accessioned2015-02-26T02:19:01Z
dc.date.available2015-02-26T02:19:01Z
dc.date.issued2015-01
dc.identifier.citationLindner, K, Haier, J, Wang, Z, Watson, DI, Hussey, DJ, Hummel, R 2015 'Circulating microRNAs: emerging biomarkers for diagnosis and prognosis in patients with gastrointestinal cancers', Clinical Science, 128 (1) pp. 1-15.en
dc.identifier.issn0143-5221
dc.identifier.urihttp://hdl.handle.net/2328/35250
dc.descriptionAuthor version made available in accordance with the publisher's policy. Under embargo for 6 months from time of publication. The final version of record is available at http://www.clinsci.org/cs/128/0001/cs1280001.htmen
dc.description.abstractTo identify novel non-invasive biomarkers for improved detection, risk assessment and prognostic evaluation of cancer, expression profiles of circulating microRNAs are currently under evaluation. Circulating microRNAs are highly promising candidates in this context, as they present some key characteristics for cancer biomarkers: they are tissue-specific with reproducible expression and consistency among individuals from the same species, they are potentially derived directly from the tumor and therefore might correlate with tumor progression and recurrence, and they are bound to proteins or contained in sub-cellular particles such as microvesicles or exosomes, making them highly stable and resistant to degradation. This review highlights the origin of circulating microRNAs, their stability in blood samples, and techniques to isolate exosomal microRNAs, and then addresses the current evidence supporting potential clinical applications for circulating miRNAs for diagnostic and prognostic purposes.en
dc.language.isoen
dc.publisherPortland Pressen
dc.relationhttp://purl.org/au-research/grants/nhmrc/1022420en
dc.relationhttp://purl.org/au-research/grants/nhmrc/1022720en
dc.rights© The Authors Journal compilation © 2015 Biochemical Societyen
dc.titleCirculating microRNAs: emerging biomarkers for diagnosis and prognosis in patients with gastrointestinal cancersen
dc.typeArticleen
dc.relation.grantnumberNHMRC/1022420en
dc.relation.grantnumberNHMRC/1022720en
dc.identifier.doihttps://doi.org/10.1042/CS20140089en
dc.rights.holderThe Authors Journal compilation, Biochemical Societyen
local.contributor.authorOrcidLookupHussey, Damian James: https://orcid.org/0000-0002-6121-6740en_US
local.contributor.authorOrcidLookupWatson, David Ian: https://orcid.org/0000-0002-7683-2693en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record