Show simple item record

dc.contributor.authorAlhmoud, Hashim Z
dc.contributor.authorGuinan, Taryn M
dc.contributor.authorElnathan, Roey
dc.contributor.authorKobus, Hilton John
dc.contributor.authorVoelcker, Nicolas Hans
dc.date.accessioned2015-11-03T05:20:03Z
dc.date.available2015-11-03T05:20:03Z
dc.date.issued2014-09-22
dc.identifier.citationAlhmoud, HZ, Guinan, T M, Elnathan, R, Kobus, H, & Voelcker, N H (2014) Surface-assisted laser desorption/ionization mass spectrometry using ordered silicon nanopillar arrays, Analyst 139, pp. 5000-6009.en
dc.identifier.issn0003-2654
dc.identifier.urihttp://dx.doi.org/10.1039/C4AN01391C
dc.identifier.urihttp://hdl.handle.net/2328/35714
dc.descriptionThis article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/)en
dc.description.abstractSurface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is ideally suited for the highthroughput analysis of small molecules in bodily fluids (e.g. saliva, urine, and blood plasma). A key application for this technique is the testing of drug consumption in the context of workplace, roadside, athlete sports and anti-addictive drug compliance. Here, we show that vertically-aligned ordered silicon nanopillar (SiNP) arrays fabricated using nanosphere lithography followed by metal-assisted chemical etching (MACE) are suitable substrates for the SALDI-MS detection of methadone and small peptides. Porosity, length and diameter are fabrication parameters that we have explored here in order to optimize analytical performance. We demonstrate the quantitative analysis of methadone in MilliQ water down to 32 ng mL 1. Finally, the capability of SiNP arrays to facilitate the detection of methadone in clinical samples is also demonstrated.en
dc.language.isoen
dc.publisherRoyal Society of Chemistryen
dc.rightsThis journal is © The Royal Society of Chemistry 2014en
dc.titleSurface-assisted laser desorption/ionization mass spectrometry using ordered silicon nanopillar arraysen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.1039/C4AN01391Cen
dc.rights.holderThe Royal Society of Chemistryen
dc.rights.licenseCC-BY


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record