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dc.contributor.authorBowen, Joanne M
dc.contributor.authorWhite, Ian
dc.contributor.authorSmith, Lorelle T
dc.contributor.authorTsykin, Anna
dc.contributor.authorKristaly, Kerry
dc.contributor.authorThompson, Sarah K
dc.contributor.authorKarapetis, Christos Stelios
dc.contributor.authorTan, Thean Hsiang
dc.contributor.authorGame, Philip A
dc.contributor.authorIrvine, Tanya S
dc.contributor.authorHussey, Damian James
dc.contributor.authorWatson, David Ian
dc.contributor.authorKeefe, Dorothy M K
dc.date.accessioned2016-01-28T01:32:20Z
dc.date.available2016-01-28T01:32:20Z
dc.date.issued2015-03-27
dc.identifier.citationBowen J, White I, Tsykin A, Smith L, Kristaly K, Thompson SK, Karapetis CS, Tan H, Game PA, Irvine T, Hussey DJ, Watson DI, Keefe D. Pre-therapy mRNA expression of TNF is associated with treatment-induced gastrointestinal toxicity in patients with esophageal cancer: A pilot study. Supportive Care in Cancer (2015) 23:3165-3172.en
dc.identifier.issn0941-4355
dc.identifier.urihttp://hdl.handle.net/2328/35895
dc.descriptionAuthor version made available following 12 month embargo from date of publication (27 March 2015) in accordance with publisher copyright policy.en
dc.description.abstractPurpose Esophageal cancer has a high mortality rate, and its multimodality treatment is often associated with significant rates of severe toxicity. Effort is needed to uncover ways to maximize effectiveness of therapy through identification of predictive markers of response and toxicity. As such, the aim of this study was to identify genes predictive of chemoradiotherapy-induced gastrointestinal toxicity using an immune pathway-targeted approach. Methods Adults with esophageal cancer treated with chemotherapy consisting of 5-fluorouracil and cisplatin and 45–50 Gy radiation were recruited to the study. Pre-therapy-collected whole blood was analyzed for relative expression of immune genes using real-time polymerase chain reaction (RT-PCR). Gene expression was compared between patients who experienced severe regimen-related gastrointestinal toxicity vs. those experiencing mild to moderate toxicity. Results Blood from 31 patients were analyzed by RT-PCR. Out of 84 immune genes investigated, TNF was significantly elevated (2.05-fold, p = 0.025) in the toxic group (n = 12) compared to the non-toxic group (n = 19). Nausea and vomiting was the most commonly documented severe toxicity. No associations between toxicity and response, age, sex, histology, or treatment were evident. Conclusions This study supports evidence of TNF as a predictive biomarker in regimen-related gastrointestinal toxicity. Confirming these findings in a larger cohort is warranted.en
dc.language.isoen
dc.publisherSpringer Verlagen
dc.relationhttp://purl.org/au-research/grants/NHMRC/1022720en
dc.relationhttp://purl.org/au-research/grants/NHMRC/1022420en
dc.rightsCopyright © 2015 Springer-Verlag Berlin Heidelbergen
dc.titlePre-therapy mRNA expression of TNF is associated with regimen-related gastrointestinal toxicity in patients with esophageal cancer: a pilot studyen
dc.typeArticleen
dc.relation.grantnumberNHMRC/1022720en
dc.relation.grantnumberNHMRC/1022420en
dc.identifier.doihttps://doi.org/10.1007/s00520-015-2696-7en
dc.rights.holderSpringer-Verlag Berlin Heidelbergen
dc.rights.licenseIn Copyright
local.contributor.authorOrcidLookupHussey, Damian James: https://orcid.org/0000-0002-6121-6740en_US
local.contributor.authorOrcidLookupWatson, David Ian: https://orcid.org/0000-0002-7683-2693en_US


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