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dc.contributor.authorSpringelkamp, Henriet
dc.contributor.authorHohn, Rene
dc.contributor.authorMishra, Aniket
dc.contributor.authorHysi, Pirro
dc.contributor.authorKhor, Chiea Chuen
dc.contributor.authorLoomis, Stephanie J
dc.contributor.authorCooke-Bailey, Jessica N
dc.contributor.authorGibson, Jane
dc.contributor.authorThorleifsson, Gudmar
dc.contributor.authorJanssen, Sarah F
dc.contributor.authorLuo, Xiaoyan
dc.contributor.authorRamdas, Wishal D
dc.contributor.authorVithana, Eranga
dc.contributor.authorNongpiur, Monisha E
dc.contributor.authorMontgomery, Grant W
dc.contributor.authorXu, Liang
dc.contributor.authorMountain, Jenny E
dc.contributor.authorGharahkhani, Puya
dc.contributor.authorLu, Yi
dc.contributor.authorAmin, Najaf
dc.contributor.authorKarssen, Lennart C
dc.contributor.authorSim, Kar Seng
dc.contributor.authorvan Leeuwen, Elisabeth M
dc.contributor.authorIglesias, Adriana
dc.contributor.authorVerhoeven, Virginie J M
dc.contributor.authorHauser, Michael A
dc.contributor.authorLoon, Seng Chee
dc.contributor.authorDespriet, Dominiek D G
dc.contributor.authorNag, Abhishek
dc.contributor.authorVenturini, Cristina
dc.contributor.authorSanfilippo, Paul Gerard
dc.contributor.authorSchillert, Arne
dc.contributor.authorKang, Jae H
dc.contributor.authorLanders, John
dc.contributor.authorJonasson, Fridbert
dc.contributor.authorCree, Angela J
dc.contributor.authorvan Koolwijk, Leonieke M E
dc.contributor.authorRivadeneira, Fernando
dc.contributor.authorSouzeau, Emmanuelle
dc.contributor.authorJonsson, Vesteinn
dc.contributor.authorMenon, Geeta
dc.contributor.authorWeinreb, Robert Neal
dc.contributor.authorde Jong, Paulus T V M
dc.contributor.authorOostra, Ben A
dc.contributor.authorUitterlinden, Andre G
dc.contributor.authorHofman, Albert
dc.contributor.authorEnnis, Sarah
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorBurdon, Kathryn Penelope
dc.contributor.authorSpector, Tim
dc.contributor.authorMirshahi, Alireza
dc.contributor.authorSaw, Seangmei
dc.contributor.authorVingerling, Johannes R
dc.contributor.authorTeo, Yik Ying
dc.contributor.authorHaines, Jonathan L
dc.contributor.authorWolfs, Roger C W
dc.contributor.authorLemij, Hans G
dc.contributor.authorTai, E-Shyong
dc.contributor.authorJansonius, Nomdo M
dc.contributor.authorJonas, Jost B
dc.contributor.authorCheng, Ching-Yu
dc.contributor.authorAung, Tin
dc.contributor.authorViswanathan, Ananth C
dc.contributor.authorKlaver, Caroline C W
dc.contributor.authorCraig, Jamie E
dc.contributor.authorMacGregor, Stuart
dc.contributor.authorMackey, David A
dc.contributor.authorLotery, Andrew J
dc.contributor.authorStefansson, Kari
dc.contributor.authorBergen, Arthur A B B
dc.contributor.authorYoung, Terri L
dc.contributor.authorWiggs, Janey L
dc.contributor.authorPfeiffer, Norbert
dc.contributor.authorWong, Tien Yin
dc.contributor.authorPasquale, Louis R
dc.contributor.authorHewitt, Alex W
dc.contributor.authorHammond, Christopher J
dc.date.accessioned2016-02-03T23:24:49Z
dc.date.available2016-02-03T23:24:49Z
dc.date.issued2014-09
dc.identifier.citationSpringelkamp H, Hoehn R, Mishra A, Hysi P, Chuen Khor C, Loomis S, Cooke Bailey J , Gibson J, Thorleifsson G, Janssen S, Luo X, Ramdas W, Vithana E, Nongpiur M, Montgomery G, Xu L, Mountain J, Gharahkhani P, Lu Y, Amin N, Karssen L, Seng Sim K, Van Leeuwen E, Iglesias A, Verhoeven V, Hauser M, Loon SC, Despriet D, Nag A, Venturini C, Sanfilippo P, Schillert A, Kang J, Landers J, Jonasson F, Cree A, Van Koolwijk L, Rivadeneira F, Souzeau E, Jonsson V, Menon G, Weinreb R, De Jong P, Oostra B, Uitterlinden A, Hofman A, Ennis S, Thorsteinsdottir U, Burdon KP, Spector T, Mirshahi A, Saw SM, Vingerling J, Teo YY, Haines J, Wolfs R, Lemij H, Shyong Tai E, Jansonius N, Jonas J, Cheng CY, Aung T, Viswanathan A, Klaver C, Craig JE, Macgregor S, Mackey D, Lotery A, Stefansson K, Bergen A, Young T, Wiggs J, Pfeiffer N, Wong T, Pasquale L, Hewitt A, Hammond C. (2014) Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process. Nature Communications. 5: 4883en
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/2328/35930
dc.descriptionThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en
dc.description.abstractGlaucoma is characterized by irreversible optic nerve degeneration and is the most frequent cause of irreversible blindness worldwide. Here, the International Glaucoma Genetics Consortium conducts a meta-analysis of genome-wide association studies of vertical cup-disc ratio (VCDR), an important disease-related optic nerve parameter. In 21,094 individuals of European ancestry and 6,784 individuals of Asian ancestry, we identify 10 new loci associated with variation in VCDR. In a separate risk-score analysis of five case-control studies, Caucasians in the highest quintile have a 2.5-fold increased risk of primary open-angle glaucoma as compared with those in the lowest quintile. This study has more than doubled the known loci associated with optic disc cupping and will allow greater understanding of mechanisms involved in this common blinding condition.en
dc.language.isoen
dc.publisherNature Publishing Groupen
dc.relationhttp://purl.org/au-research/grants/nhmrc/1065433en
dc.relationhttp://purl.org/au-research/grants/nhmrc/1023911en
dc.rightsCopyright 2014 Macmillan Publishers Limited. All rights reserved.en
dc.subjectGeneticsen
dc.subjectGlaucomaen
dc.subjectMedical researchen
dc.titleMeta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous processen
dc.typeArticleen
dc.relation.grantnumberNHMRC/1065433en
dc.relation.grantnumberNHMRC/1023911en
dc.identifier.doihttps://doi.org/10.1038/ncomms5883en
dc.rights.holderMacmillan Publishers Limited.en
dc.rights.licenseCC-BY


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