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dc.contributor.authorBurdon, Kathryn Penelope
dc.contributor.authorMitchell, Paul
dc.contributor.authorLee, Anne
dc.contributor.authorHealey, Paul R
dc.contributor.authorWhite, Andrew J
dc.contributor.authorRochtchina, Elena
dc.contributor.authorThomas, P
dc.contributor.authorWang, Jie Jin
dc.contributor.authorCraig, Jamie E
dc.date.accessioned2016-05-16T04:40:05Z
dc.date.available2016-05-16T04:40:05Z
dc.date.issued2015
dc.identifier.citationBurdon KP, Mitchell P, Lee A, Healey PR, White AJ, Rochtchina E, Thomas PB, Wang JJ, Craig JE. Association of open-angle glaucoma loci with incident glaucoma in the Blue Mountains Eye Study. Am J Ophthalmol. 2015 Jan;159(1):31-6.e1. doi: 10.1016/j.ajo.2014.09.020. Epub 2014 Sep 19.en
dc.identifier.issn0002-9394
dc.identifier.urihttp://hdl.handle.net/2328/36106
dc.descriptionThis article is available under the terms of the Creative Commons Attribution License (CC BY). http://creativecommons.org/licenses/by/3.0/ You may distribute and copy the article, create extracts, abstracts, and other revised versions, adaptations or derivative works of or from an article (such as a translation), to include in a collective work (such as an anthology), to text or data mine the article, including for commercial purposes without permission from Elsevier. The original work must always be appropriately credited.en
dc.description.abstractPURPOSE: To determine if open-angle glaucoma (OAG)-associated single nucleotide polymorphisms (SNPs) are associated with incident glaucoma and if such genetic information is useful in OAG risk prediction. DESIGN: Case-control from within a population-based longitudinal study. METHODS: study population: Individuals aged over 49 years of age living in the Blue Mountains region west of Sydney and enrolled in the Blue Mountains Eye Study. observation: Cases for this sub-study (n = 67) developed incident OAG between baseline and 10-year visits, in either eye, while controls (n = 1919) had no evidence for OAG at any visit. All participants had an ocular examination and DNA genotyped for reported OAG risk SNPs. main outcome measure: Incident OAG. RESULTS: Two loci also known to be associated with cup-to-disc ratio as well as OAG (9p21 near CDKN2B-AS1 and SIX1/SIX6) were both significantly associated with incident OAG in the Blue Mountains Eye Study cohort (P = .006 and P = .004, respectively). The TMCO1 locus was nominally associated (P = .012), while the CAV1/CAV2 and 8q22 loci were not associated. Multivariate logistic regression and neural network analysis both indicated that the genetic risk factors contributed positively to the predictive models incorporating traditional risk factors. CONCLUSIONS: This study shows that previously reported genetic variations related to OAG and cup-to-disc ratio are associated with the onset of OAG and thus may become useful in risk prediction algorithms designed to target early treatment to those most at risk of developing glaucoma.en
dc.language.isoen
dc.publisherElsevier Inc.en
dc.relationhttp://purl.org/au-research/grants/NHMRC/595944en
dc.relationhttp://purl.org/au-research/grants/NHMRC/1065433en
dc.relationhttp://purl.org/au-research/grants/NHMRC/632909en
dc.relationhttp://purl.org/au-research/grants/NHMRC/512423en
dc.relationhttp://purl.org/au-research/grants/NHMRC/475604en
dc.relationhttp://purl.org/au-research/grants/NHMRC/529912en
dc.rightsCopyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.en
dc.titleAssociation of open-angle glaucoma loci with incident glaucoma in the Blue Mountains Eye Study.en
dc.typeArticleen
dc.relation.grantnumberNHMRC/595944en
dc.relation.grantnumberNHMRC/1065433en
dc.relation.grantnumberNHMRC/632909en
dc.relation.grantnumberNHMRC/512423en
dc.relation.grantnumberNHMRC/475604en
dc.relation.grantnumberNHMRC/529912en
dc.identifier.doihttps://doi.org/10.1016/j.ajo.2014.09.020en
dc.rights.holderThe Authors.en


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