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dc.contributor.authorNorris, Matthew D
dc.contributor.authorPerkins, Michael Victor
dc.date.accessioned2016-05-29T23:21:42Z
dc.date.available2016-05-29T23:21:42Z
dc.date.issued2016
dc.identifier.citationNorris MD, Perkins MV. Structural diversity and chemical synthesis of peroxide and peroxide-derived polyketide metabolites from marine sponges. Natural Product Reports. 2016 May 10. [Epub ahead of print] Review.en
dc.identifier.issn0265-0568
dc.identifier.urihttp://hdl.handle.net/2328/36135
dc.descriptionThis article is licensed under a Creative Commons Attribution 3.0 Unported Licence. http://creativecommons.org/licenses/by/3.0/en
dc.description.abstractMarine sponges are widely known as a rich source of natural products, especially of polyketide origin, with a wealth of chemical diversity. Within this vast collection, peroxide and peroxide-derived secondary metabolites have attracted significant interest in the fields of natural product isolation and chemical synthesis for their structural distinction and promising in vitro antimicrobial and anticancer properties. In this review, peroxide and peroxide-derived polyketide metabolites isolated from marine sponges in the past 35 years are summarised. Efforts toward their synthesis are detailed with a focus on methods that utilise or attempt to elucidate the complex biosynthetic interrelationships of these compounds beyond enzymatic polyketide synthesis. Recent isolations, advances in synthetic methodology and theories of biogenesis are highlighted and critically evaluated.en
dc.language.isoen
dc.publisherRoyal Society of Chemistryen
dc.rightsThis journal is © The Royal Society of Chemistry 2016en
dc.titleStructural diversity and chemical synthesis of peroxide and peroxide-derived polyketide metabolites from marine spongesen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.1039/c5np00142ken
dc.rights.holderThis journal is © The Royal Society of Chemistry 2016en
dc.rights.licenseCC-BY
local.contributor.authorOrcidLookupPerkins, Michael Victor: https://orcid.org/0000-0003-1706-2315en_US


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