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dc.contributor.authorLeibbrandt, Richard Eduard
dc.contributor.authorDinning, Phillip
dc.contributor.authorCosta, Marcello
dc.contributor.authorCock, Charles
dc.contributor.authorWiklendt, Lukasz
dc.contributor.authorWang, Guangsong
dc.contributor.authorTack, Jan
dc.contributor.authorvan Beckevoort, Dirk
dc.contributor.authorRommel, Nathalie
dc.contributor.authorOmari, Taher
dc.date.accessioned2016-06-06T00:46:27Z
dc.date.available2016-06-06T00:46:27Z
dc.date.issued2016
dc.identifier.citationLeibbrandt RE, Dinning PG, Costa M, Cock C, Wiklendt L, Wang G, Tack J, van Beckevoort D, Rommel N, Omari TI. Characterization of Esophageal Physiology Using Mechanical State Analysis. Front Syst Neurosci. 2016 Feb 17;10:10. doi: 10.3389/fnsys.2016.00010.en
dc.identifier.issn1662-5137
dc.identifier.urihttp://hdl.handle.net/2328/36171
dc.descriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.description.abstractThe esophagus functions to transport swallowed fluids and food from the pharynx to the stomach. The esophageal muscles governing bolus transport comprise circular striated muscle of the proximal esophagus and circular smooth muscle of the distal esophagus. Longitudinal smooth muscle contraction provides a mechanical advantage to bolus transit during circular smooth muscle contraction. Esophageal striated muscle is directly controlled by neural circuits originating in the central nervous system, resulting in coordinated contractions. In contrast, the esophageal smooth muscle is controlled by enteric circuits modulated by extrinsic central neural connections resulting in neural relaxation and contraction. The esophageal muscles are modulated by sensory information arising from within the lumen. Contraction or relaxation, which changes the diameter of the lumen, alters the intraluminal pressure and ultimately inhibits or promotes flow of content. This relationship that exists between the changes in diameter and concurrent changes in intraluminal pressure has been used previously to identify the "mechanical states" of the circular muscle; that is when the muscles are passively or actively, relaxing or contracting. Detecting these changes in the mechanical state of the muscle has been difficult and as the current interpretation of esophageal motility is based largely upon pressure measurement (manometry), subtle changes in the muscle function during peristalsis can be missed. We hypothesized that quantification of mechanical states of the esophageal circular muscles and the pressure-diameter properties that define them, would allow objective characterization of the mechanisms that govern esophageal peristalsis. To achieve this we analyzed barium swallows captured by simultaneous videofluoroscopy and pressure with impedance recording. From these data we demonstrated that intraluminal impedance measurements could be used to determine changes in the internal diameter of the lumen comparable with measurements from videofluoroscopy. Our data indicated that identification of mechanical state of esophageal muscle was simple to apply and revealed patterns consistent with the known neural inputs activating the different muscles during swallowing.en
dc.language.isoen
dc.publisherFrontiers Mediaen
dc.rightsCopyright © 2016 Leibbrandt, Dinning, Costa, Cock, Wiklendt, Wang, Tack, van Beckevoort, Rommel and Omari.en
dc.subjectdysphagia; esophageal peristalsis; impedance; neural pathways; pressure; swallowen
dc.titleCharacterization of Esophageal Physiology Using Mechanical State Analysisen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.3389/fnsys.2016.00010en
dc.rights.holderThe Authorsen
local.contributor.authorOrcidLookupOmari, Taher: https://orcid.org/0000-0001-5108-7378en_US
local.contributor.authorOrcidLookupCock, Charles: https://orcid.org/0000-0003-3578-1137en_US
local.contributor.authorOrcidLookupCosta, Marcello: https://orcid.org/0000-0003-1817-0158en_US
local.contributor.authorOrcidLookupLeibbrandt, Richard Eduard: https://orcid.org/0000-0003-2442-0782en_US


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