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dc.contributor.authorHarkess, K N
dc.contributor.authorRyan, J
dc.contributor.authorDelfabbro, Paul
dc.contributor.authorCohen-Woods, Sarah
dc.date.accessioned2017-03-21T02:41:22Z
dc.date.available2017-03-21T02:41:22Z
dc.date.issued2016-11-29
dc.identifier.citationChicago/Turabian (16th edition) MLA (7th edition) Citation Harkess, K., Delfabbro, J., Ryan, P., & Cohen-Woods, S. (2016). Preliminary indications of the effect of a brief yoga intervention on markers of inflammation and DNA methylation in chronically stressed women. Translational Psychiatry, 6(11),en
dc.identifier.issn2158-3188
dc.identifier.urihttp://hdl.handle.net/2328/36966
dc.description© The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if thematerial is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.en
dc.description.abstractYoga is associated with reduced stress and increased well-being, although the molecular basis for these benefits is not clear. Mounting evidence implicates the immune response, with current studies focused on protein immune markers (such as cytokines) in clinical populations. To explore the molecular impact, this pilot study uses a subsample (n = 28) from a randomised waitlist control trial Investigating the impact of an 8-week yoga intervention in a community population of women reporting psychological distress (N = 116). We measured interleukin-6 (IL-6), tumour necrosis factor (TNF) and C-reactive protein (CRP) protein levels, and the DNA methylation of these genes and the global indicator, LINE-1. Correlations between these and psychological variables were explored, identifying moderate correlations with CRP protein levels, and methylation of IL-6, CRP and LINE-1. Many cytokine samples were below detection, however a Mann–Whitney U demonstrated a trend of moderate between-group effect for elevated IL-6 in the yoga group. Methylation analyses applied cross-sectional and non-controlled longitudinal analyses. Waist-to-height ratio and age were covaried. We demonstrated reduced methylation of the TNF region in the yoga group relative to the waitlist control group. No other genes demonstrated a significant difference. Longitudinal analysis further supported these results. This study is one of the first to explore yoga and immunological markers in a non-clinical population, and is the first study to explore DNA methylation. These findings indicate that further research into molecular impact of yoga on markers of immune function is warranted, with larger studies required.en
dc.language.isoen
dc.publisherMacmillan Publishers Limiteden
dc.rights© The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if thematerial is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.en
dc.subjectYogaen
dc.subjectstressen
dc.subjectprotein immune markersen
dc.subjectcytokinesen
dc.subjectpsychological distressen
dc.subjectmethylationen
dc.titlePreliminary indications of the effect of a brief yoga intervention on markers of inflammation and DNA methylation in chronically stressed womenen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.1038/tp.2016.234en
dc.rights.holderThe Authorsen
dc.rights.licenseCC-BY


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