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dc.contributor.authorPlummer, Mark P
dc.contributor.authorFinnis, Mark E
dc.contributor.authorPhillips, Liza K
dc.contributor.authorKar, Palash
dc.contributor.authorBihari, Shailesh
dc.contributor.authorBiradar, Vishwanath
dc.contributor.authorMoodie, Stewart
dc.contributor.authorHorowitz, Michael
dc.contributor.authorShaw, Jonathan E
dc.contributor.authorDeane, Adam M
dc.date.accessioned2017-04-03T23:13:35Z
dc.date.available2017-04-03T23:13:35Z
dc.date.issued2016-11-08
dc.identifier.citationPlummer MP, Finnis ME, Phillips LK, Kar P, Bihari S, Biradar V, et al. (2016) Stress Induced Hyperglycemia and the Subsequent Risk of Type 2 Diabetes in Survivors of Critical Illness. PLoS ONE 11(11): e0165923. doi:10.1371/journal. pone.0165923en
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/2328/37058
dc.descriptionThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.description.abstractObjective Stress induced hyperglycemia occurs in critically ill patients who have normal glucose tolerance following resolution of their acute illness. The objective was to evaluate the association between stress induced hyperglycemia and incident diabetes in survivors of critical illness. Design Retrospective cohort study. Setting All adult patients surviving admission to a public hospital intensive care unit (ICU) in South Australia between 2004 and 2011. Patients Stress induced hyperglycemia was defined as a blood glucose ≥ 11.1 mmol/L (200 mg/dL) within 24 hours of ICU admission. Prevalent diabetes was identified through ICD-10 coding or prior registration with the Australian National Diabetes Service Scheme (NDSS). Incident diabetes was identified as NDSS registration beyond 30 days after hospital discharge until July 2015. The predicted risk of developing diabetes was described as sub-hazard ratios using competing risk regression. Survival was assessed using Cox proportional hazards regression. Main Results Stress induced hyperglycemia was identified in 2,883 (17%) of 17,074 patients without diabetes. The incidence of type 2 diabetes following critical illness was 4.8% (821 of 17,074). The risk of diabetes in patients with stress induced hyperglycemia was approximately double that of those without (HR 1.91 (95% CI 1.62, 2.26), p<0.001) and was sustained regardless of age or severity of illness. Conclusions Stress induced hyperglycemia identifies patients at subsequent risk of incident diabetes.en
dc.language.isoen
dc.publisherPublic Library of Scienceen
dc.rightsCopyright: © 2016 Plummer et al.en
dc.subjecthyperglycemiaen
dc.subjectdiabetesen
dc.subjectsurvivors of critical illnessen
dc.subjectRetrospective cohort study.en
dc.subjectStress Induced Hyperglycemiaen
dc.subjectType 2 Diabetesen
dc.titleStress Induced Hyperglycemia and the Subsequent Risk of Type 2 Diabetes in Survivors of Critical Illnessen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0165923
dc.rights.holderThe authorsen
dc.rights.licenseCC-BY


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