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dc.contributor.authorKargarfard, Fatemeh
dc.contributor.authorSami, Ashkan
dc.contributor.authorMohammadi-Dehcheshmeh, Manijeh
dc.contributor.authorEbrahimie, Esmaeil
dc.date.accessioned2017-04-04T02:52:09Z
dc.date.available2017-04-04T02:52:09Z
dc.date.issued2016-11-16
dc.identifier.citationKargarfard, Fatemeh, Ashkan Sami, Manijeh Mohammadi-Dehcheshmeh, and Esmaeil Ebrahimie. "Novel Approach for Identification of Influenza Virus Host Range and Zoonotic Transmissible Sequences by Determination of Host-related Associative Positions in Viral Genome Segments." BMC Genomics 17.1 (2016): BMC Genomics, Nov 16, 2016, Vol.17(1). Web.en
dc.identifier.issn1471-2164
dc.identifier.urihttp://hdl.handle.net/2328/37068
dc.descriptionThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.description.abstractBackground Recent (2013 and 2009) zoonotic transmission of avian or porcine influenza to humans highlights an increase in host range by evading species barriers. Gene reassortment or antigenic shift between viruses from two or more hosts can generate a new life-threatening virus when the new shuffled virus is no longer recognized by antibodies existing within human populations. There is no large scale study to help understand the underlying mechanisms of host transmission. Furthermore, there is no clear understanding of how different segments of the influenza genome contribute in the final determination of host range. Methods To obtain insight into the rules underpinning host range determination, various supervised machine learning algorithms were employed to mine reassortment changes in different viral segments in a range of hosts. Our multi-host dataset contained whole segments of 674 influenza strains organized into three host categories: avian, human, and swine. Some of the sequences were assigned to multiple hosts. In point of fact, the datasets are a form of multi-labeled dataset and we utilized a multi-label learning method to identify discriminative sequence sites. Then algorithms such as CBA, Ripper, and decision tree were applied to extract informative and descriptive association rules for each viral protein segment. Result We found informative rules in all segments that are common within the same host class but varied between different hosts. For example, for infection of an avian host, HA14V and NS1230S were the most important discriminative and combinatorial positions. Conclusion Host range identification is facilitated by high support combined rules in this study. Our major goal was to detect discriminative genomic positions that were able to identify multi host viruses, because such viruses are likely to cause pandemic or disastrous epidemics.en
dc.language.isoen
dc.publisherBioMed Centralen
dc.rights© The Author(s). 2016en
dc.subjectAssociation rule miningen
dc.subjectHost range of influenzaen
dc.subjectDetecting hot spotsen
dc.titleNovel approach for identification of influenza virus host range and zoonotic transmissible sequences by determination of host-related associative positions in viral genome segmentsen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.1186/s12864-016-3250-9en
dc.rights.holderThe Author(s)en


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