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dc.contributor.authorHan, L
dc.contributor.authorYan, L
dc.contributor.authorWang, K
dc.contributor.authorFang, L
dc.contributor.authorZhang, H
dc.contributor.authorTang, Youhong
dc.contributor.authorDing, Y
dc.contributor.authorWeng, L
dc.contributor.authorXu, J
dc.contributor.authorWeng, J
dc.contributor.authorLiu, Y
dc.contributor.authorRen, F
dc.contributor.authorLu, X
dc.date.accessioned2017-06-05T23:15:05Z
dc.date.available2017-06-05T23:15:05Z
dc.date.issued2017-04-14
dc.identifier.citationLu Han, Liwei Yan, Kefeng Wang, Liming Fang, Hongping Zhang, Youhong Tang, . . . Xiong Lu. (2017). Tough, self-healable and tissue-adhesive hydrogel with tunable multifunctionality. NPG Asia Materials, 9(4),en
dc.identifier.issn1884-4057
dc.identifier.urihttp://hdl.handle.net/2328/37258
dc.descriptionThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en
dc.description.abstractAn ideal hydrogel for biomedical engineering should mimic the intrinsic properties of natural tissue, especially high toughness and self-healing ability, in order to withstand cyclic loading and repair skin and muscle damage. In addition, excellent cell affinity and tissue adhesiveness enable integration with the surrounding tissue after implantation. Inspired by the natural mussel adhesive mechanism, we designed a polydopamine–polyacrylamide (PDA–PAM) single network hydrogel by preventing the overoxidation of dopamine to maintain enough free catechol groups in the hydrogel. Therefore, the hydrogel possesses super stretchability, high toughness, stimuli-free self-healing ability, cell affinity and tissue adhesiveness. More remarkably, the current hydrogel can repeatedly be adhered on/stripped from a variety of surfaces for many cycles without loss of adhesion strength. Furthermore, the hydrogel can serve as an excellent platform to host various nano-building blocks, in which multiple functionalities are integrated to achieve versatile potential applications, such as magnetic and electrical therapies.en
dc.language.isoen
dc.publisherNature Publishing Groupen
dc.rights© The Author(s) 2017en
dc.subjecthydrogelen
dc.subjectbiomedical engineeringen
dc.subjectpolydopamine–polyacrylamideen
dc.titleTough, self-healable and tissue-adhesive hydrogel with tunable multifunctionalityen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.1038/am.2017.33en
dc.rights.holderThe Author(s)en
local.contributor.authorOrcidLookupTang, Youhong: https://orcid.org/0000-0003-2718-544Xen_US


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