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dc.contributor.authorLegge, Rebecca MacGregor
dc.contributor.authorSendi, Shahbaz
dc.contributor.authorCole, James H
dc.contributor.authorCohen-Woods, Sarah
dc.contributor.authorCostafreda, Sergi G
dc.contributor.authorSimmons, Andrew
dc.contributor.authorFarmer, Anne E
dc.contributor.authorAitchison, Katherine J
dc.contributor.authorMcGuffin, Peter W
dc.contributor.authorFu, Cynthia H Y
dc.date.accessioned2017-06-07T06:08:28Z
dc.date.available2017-06-07T06:08:28Z
dc.date.issued2015-05
dc.identifier.citationRebecca MacGregor Legge, Shahbaz Sendi, James H. Cole, Sarah Cohen-Woods, Sergi G. Costafreda, Andrew Simmons, Anne E. Farmer, Katherine J. Aitchison, Peter McGuffin, Cynthia H. Y. Fu The British Journal of Psychiatry May 2015, 206 (5) 379-384; DOI: 10.1192/bjp.bp.113.143529en
dc.identifier.issn1472-1465
dc.identifier.urihttp://hdl.handle.net/2328/37274
dc.descriptionThis is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) licence.en
dc.description.abstractBackground Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism contributes to the development of depression (major depressive disorder, MDD), but it is unclear whether neural effects observed in healthy individuals are sustained in MDD. Aims To investigate BDNF Val66Met effects on key regions in MDD neurocircuitry: amygdala, anterior cingulate, middle frontal and orbitofrontal regions. Method Magnetic resonance imaging scans were acquired in 79 persons with MDD (mean age 49 years) and 74 healthy volunteers (mean age 50 years). Effects on surface area and cortical thickness were examined with multiple comparison correction. Results People who were Met allele carriers showed reduced caudal middle frontal thickness in both study groups. Significant interaction effects were found in the anterior cingulate and rostral middle frontal regions, in which participants in the MDD group who were Met carriers showed the greatest reduction in surface area. Conclusions Modulatory effects of the BDNF Val66Met polymorphism on distinct subregions in the prefrontal cortex in MDD support the neurotrophin model of depression.en
dc.language.isoen
dc.publisherRoyal College of Psychiatristsen
dc.rights© The Royal College of Psychiatrists 2015.en
dc.subjectBrain-derived neurotrophic factor (BDNF)en
dc.subjectpolymorphismen
dc.subjectdepressionen
dc.subjectMajor depressive disorder (MDD)en
dc.titleModulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorderen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.1192/bjp.bp.113.143529en
dc.rights.holderThe Royal College of Psychiatristsen
dc.rights.licenseCC-BY


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