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dc.contributor.authorDixon, Dani Louise
dc.contributor.authorDe Pasquale, Carmine Gerardo
dc.contributor.authorLawrence, Mark D
dc.contributor.authorCavallaro, Elena
dc.contributor.authorRubino, Vito
dc.contributor.authorBersten, Andrew David
dc.date.accessioned2017-08-09T00:48:59Z
dc.date.available2017-08-09T00:48:59Z
dc.date.issued2017-05-26
dc.identifier.citationDixon, D.-L., De Pasquale, C. G., Lawrence, M. D., Cavallaro, E., Rubino, V., & Bersten, A. D. (2017). Lung fluid clearance in chronic heart failure patients. International Journal of Cardiology, 244, 245–247. https:// doi.org/10.1016/j.ijcard.2017.05.096en
dc.identifier.issn0167-5273
dc.identifier.urihttp://hdl.handle.net/2328/37406
dc.description© 2017 Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This author accepted manuscript is made available following 12 month embargo from date of publication (May 2017) in accordance with the publisher’s archiving policyen
dc.description.abstractChronic elevation of pulmonary microvascular pressure (Pmv) consistently leads to alveolocapillary barrier thickening and reduction in the filtration coefficient. In animal models of chronic heart failure (CHF) the lung remains dry despite hydrostatic forces. As fluid flux is bi-directional, it has been postulated that an increase in alveolar fluid clearance may facilitate the dry lung when Pmv is chronically elevated. In this study we aimed to examine alveolar fluid clearance in ambulatory patients with CHF secondary to left ventricular (LV) systolic dysfunction compared against non-CHF controls. Lung clearance following aerosol delivery of 99mtechnetium (Tc)-diethyl triaminepentaacetic acid (DTPA) was measured non-invasively by scintigraphy and half time of 99mTc-DTPA clearance (T (1/2)) was calculated by mono-exponential curve fit. Alveolar fluid clearance measured as half time DTPA clearance was significantly faster in CHF patients than controls (P = 0.001). This was further defined by NYHA classification. No correlation was found between DTPA clearance and plasma epinephrine, norepinephrine or aldosterone hormone (P > 0.05). Our results support an association between increasing alveolar fluid clearance and disease severity in CHF, and the concept of controlled bi-directional fluid flux in CHF associated with increasing Pmv, and represents another defence mechanism of the lung against pulmonary oedema.en
dc.language.isoen
dc.publisherElsevieren
dc.rights© 2017 Elsevier.en
dc.subjectChronic heart failureen
dc.subjectPulmonary fluid clearanceen
dc.subjectAerosol scintigraphyen
dc.subjectCatecholaminesen
dc.titleLung Fluid Clearance in Chronic Heart Failure Patientsen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.1016/j.ijcard.2017.05.096en
dc.rights.holderElsevier. Ten
local.contributor.authorOrcidLookupDixon, Dani Louise: https://orcid.org/0000-0001-6459-1856en_US


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