In vivo targeted therapy of gastric tumors via the mechanical rotation of a flower-like Fe3O4@Au nanoprobe under an alternating magnetic field
Shapter, Joseph George
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Owing to their hypotoxicity, great spatial resolution and tomographic properties, Fe3O4 nanoparticles (NPs) are becoming one of the most promising materials for noninvasive biological imaging and shape-dependent therapeutic agents for malignant tumor therapy. Conventional spherical NPs are unable to effectively destroy cellular structure in therapy and thus result in tumors with a high risk of drug resistance. Herein we developed a novel flower-like targeting Fe3O4@Au-HPG-Glc nanoprobe (thiol-containing hyperbranched polyglycerol (HPG); 4-aminophenyl β-D-glucopyranoside (Glc)) that can enhance magnetic resonance imaging (MRI) for cancer therapy. With the guidance of a targeting molecule, Fe3O4@Au-HPG-Glc nanoprobes can precisely target tumor cells. Under an alternating magnetic field (AMF), the flower-like Fe3O4@Au-HPG-Glc nanoprobes can rotate along the central axis of the core to substantially destroy tumor cells by damaging the nucleus or cell membrane. Our results showed that this shape-dependent therapeutic agent-based strategy had remarkable efficacy for MRI-guided tumor therapy. Furthermore, the inhibition of tumor growth in tumor-bearing mice was up to approximately 47.3% on the twelfth day of treatment compared with the level of inhibition in a blank group. Different from other reported methods for cancer therapy, our proposed AMF-dependent targeted cancer therapy is a novel strategy that can potentially reduce drug resistance in gastric tumors.