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dc.contributor.authorSingendonk, Maartje M J
dc.contributor.authorOmari, Taher
dc.contributor.authorRommel, Nathalie
dc.contributor.authorvan Wijk, Michiel P
dc.contributor.authorBenninga, Marc Alexander
dc.contributor.authorRosen, Gaye
dc.contributor.authorNurko, Samuel J
dc.date.accessioned2018-04-03T05:45:46Z
dc.date.available2018-04-03T05:45:46Z
dc.date.issued2018-01
dc.identifier.citationSingendonk, M. M. J., Omari, T. I., Rommel, N., van Wijk, M. P., Benninga, M. A., Rosen, R., & Nurko, S. (2018). Novel Pressure-Impedance Parameters for Evaluating Esophageal Function in Pediatric Achalasia. Journal of Pediatric Gastroenterology and Nutrition, 66(1), 37–42. https://doi.org/10.1097/mpg.0000000000001647en
dc.identifier.issn0277-2116
dc.identifier.urihttp://hdl.handle.net/2328/37836
dc.description.abstractObjective: In achalasia, absent peristalsis and reduced esophagogastric junction (EGJ) relaxation and compliance underlie dysphagia symptoms. Novel high-resolution impedance manometry variables, that is, bolus presence time (BPT) and trans-EGJ-bolus flow time (BFT) have been developed to estimate the duration of EGJ opening and trans-EGJ bolus flow. The aim of this study was to evaluate esophageal motor function and bolus flow in children diagnosed with achalasia using these variables. Methods: High-resolution impedance manometry recordings from 20 children who fulfilled the Chicago Classification (V3) criteria for achalasia were compared with recordings of 15 children with normal esophageal high-resolution manometry findings and no other evidence suggestive of achalasia. Matlab-based analysis software was used to calculate BPT and BFT. Results: Both BPT and BFT were significantly reduced in achalasia patients compared with children with normal esophageal motility (BPT 3.3 s vs 5.1 s P < 0.01; BFT 1.4 s vs 4.3 s P < 0.001). BFT was significantly lower than BPT (achalasia difference 1.9 s ± 1.3 s, P = 0.001 and normal difference 0.9 ± 0.3 s, P = 0.001). Overall, there was a significant correlation between BPT and BFT (r = 0.825, P < 0.001). We observed a 2-way differentiation of achalasia patients; those in whom the BPT and BFT were proportional, but significantly lower than in patients with normal peristalsis, and those in whom BFT was disproportionately lower than BPT. Conclusions: Calculation of BPT and BFT may help determine whether esophageal bolus transport to the EGJ and/or esophageal emptying through the EGJ are aberrant. For achalasia, this may detect flow resistance at the EGJ, potentially improving both diagnosis and objective assessment of therapeutic effects.en_US
dc.language.isoen
dc.publisherLippincott Williams & Wilkins, Inc.en
dc.rights© 2018 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology.en
dc.subjectachalasiaen
dc.subjectdysphagiaen
dc.subjectesophagogastric junction (EGJ)en
dc.subjectachalasiaen
dc.subjectchildrenen
dc.titleNovel pressure-impedance parameters for evaluating esophageal function in pediatric achalasiaen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.1097/MPG.0000000000001647en
dc.rights.holderEuropean Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,en
dc.rights.licenseIn Copyright
local.contributor.authorOrcidLookupOmari, Taher: https://orcid.org/0000-0001-5108-7378en_US


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