Self-Reported Health Status of Donor Conceived Adults.
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Introduction: We previously conducted systematic reviews and meta-analyses of donor egg and sperm neonatal outcomes. Donor egg neonates were significantly more likely to be born of low birth weight (<2500g), very low birth weight (<1500g), and preterm (<37 weeks), compared to those conceived with autologous oocytes. Donor sperm neonates were significantly more likely to be born of low birth weight and with more birth defects than those conceived naturally. The Fetal Origins of Adult Disease hypothesis states that there are some instances of adult diseases that have their origins in-utero. Specifically, those people who have had a poor start in life and at birth, such as being small for gestational age or born prematurely, are more likely to suffer various conditions in adulthood. The systematic review also showed that there were no studies conducted to date looking at the long term health outcomes of donor conceived adults. We therefore conducted an exploratory online self-reported health survey comparing donor conceived adults to those conceived naturally. Methodology: Anonymous respondents from around the world were recruited via snowballing using social media. Various organizations that are involved in donor conception also advertised the survey to their members. Furthermore, some respondents were recruited via the survey website Prolific. Respondents completed a 185 question survey that was approved by Flinders SBREC. Results: The total number of respondents was 1159, with 282 respondents being donor conceived and 877 naturally conceived. Donor conceived adults reported significant differences in general health and some demographics, as well as differing levels of being diagnosed with various conditions in the areas of mental health, EENT, endocrinology, gastrointestinal, immunology, musculoskeletal, and respiratory systems. Conclusion: Donor conceived adults have poorer self-reported health outcomes than naturally conceived adults.
This abstract was prepared for the inaugural 'HDR Student Conference', Flinders University, November 2018. Copyright © the author