Show simple item record

dc.contributor.authorAlghazwi, Mousaen_US
dc.contributor.authorSmid, Scotten_US
dc.contributor.authorMusgrave, Ianen_US
dc.contributor.authorZhang, Weien_US
dc.date.accessioned2019-02-08T05:39:55Z
dc.date.available2019-02-08T05:39:55Z
dc.date.issued2019-01-09
dc.identifier.citationAlghazwi, M., Smid, S., Musgrave, I., & Zhang, W. (2019). In vitro studies of the neuroprotective activities of astaxanthin and fucoxanthin against amyloid beta (Aβ1-42) toxicity and aggregation. Neurochemistry International, 124, 215–224. https://doi.org/10.1016/j.neuint.2019.01.010en_US
dc.identifier.issn0197-0186
dc.identifier.urihttp://hdl.handle.net/2328/38936
dc.descriptionCrown Copyright © 2019 Published by Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license: http://creativecommons.org/licenses/by-nc-nd/4.0/ This author accepted manuscript is made available following 12 month embargo from date of publication (January 2019) in accordance with the publisher’s archiving policyen_US
dc.description.abstractAmyloid beta (Aβ) can aggregate and form plaques, which are considered as one of the major hallmarks of Alzheimer's disease. This study aims to directly compare the neuroprotective activities in vitro of two marine-derived carotenoids astaxanthin and fucoxanthin that have shown a spectrum of biological activities, including neuroprotection. The in vitro neuroprotective activities were investigated against Aβ1-42-mediated toxicity in pheochromocytoma (PC-12) neuronal cells using the MTT cell viability assay, anti-apoptotic, antioxidant and neurite outgrowth activities; as well as inhibition against Aβ1-42 fibrillization in the Thioflavin T (ThT) assay of fibril kinetics and via transmission electron microscopic (TEM) evaluation of fibril morphology. The results demonstrated that both astaxanthin and fucoxanthin exhibited multi-neuroprotective effects favouring fucoxanthin over astaxanthin supporting neuroprotective roles of marine-derived carotenoids as potential novel dementia prevention or therapeutic strategies.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsCrown Copyright © 2019 Published by Elsevier Ltd.en_US
dc.subjectAstaxanthinen_US
dc.subjectfucoxanthinen_US
dc.subjectneuroprotectionen_US
dc.subjectamyloid betaen_US
dc.subjectAlzheimer’s diseaseen_US
dc.titleIn vitro studies of the neuroprotective activities of astaxanthin and fucoxanthin against amyloid beta (Aβ1-42) toxicity and aggregationen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1016/j.neuint.2019.01.010en_US
dc.rights.holderCrown Copyrighten_US
dc.rights.licenseCC-BY-NC-ND
local.contributor.authorOrcidLookupAlghazwi, Mousa: https://orcid.org/0000-0002-7480-981Xen_US
local.contributor.authorOrcidLookupMusgrave, Ian: https://orcid.org/0000-0003-1016-0588en_US
local.contributor.authorOrcidLookupZhang, Wei: https://orcid.org/0000-0002-5111-4097en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record